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  • TDS Moderators: AlphaMethylPhenyl | paranoid android

Withdrawing from Nardil - very worried

I've been reading this thread with interest. It seemsto me you have worked through an enormous amount. Of personal baggage.

Through it all of you've done well! Yes you have and are having some difficulties but you recognize them! That's excellent!
I can't say wether you were better on the nordil or not. Only you and your dr. Can do that. Maybe other meds and counseling will help. But in the meantime celebrate the good that has come of this. You have one well!
 
Thanks man :)

Would you believe the scales are now telling me I have lost 10kg?!
Thats like 22lbs in less than 5 weeks! My body shape has totally changed, I was looking at some pics of the past year and I was a propper fat barstard, now, clotes I could not possibally squeese myself into a month ago are falling off me! Happy where I am now but I will push my weight down to about 76kg before I stop taking metformin, which by the way is amazing stuff. I am pretty good at ignoring hunger (now that I have stopped Nardil) but the metformin stops my blood sugar dropping so I dont get any of the side effects from calorie restriction.
I think I am probably eating about 4000 odd kj per day with a little exercise.

I looked at a photo of my ex tonight and I felt nothing which is great. I have been going through a major drama with a retailer in Melbourne trying to screw me for $1500 which is still ongoing. I think having something else to stress about pushed her out of my head.

I am still struggling at times, mood is quite labile. I have a script for carbamazapine that I havnt filled (imagine the added weight loss if I chuck that in too!) I might experiment with a low dose and see if it gives me a bit more stability.
Even though the one Nardil at night is holding me, I still really want to get off it totally.
 
I read your story here and kind of know what you're going through. It sucks because these AD's can really help turn your life around.....for a while. Then they either stop working or the side effects outweigh their benefits. IMHO, the sooner you get off the MAOI type drugs, the better. The interactions alone have kept me away from them.

I save my AD use only for major depressive episodes because I know their therapeutic benefit is short lived (for me anyway).
 
Hi
22 kgs in 5 wks is amazing. It just shows how it slowed your metabolism and increased food cravings.
Also seeing your exes picture with little emotion shows how far you've really come. In my experience once you stop with the bitterness vs all the sappy I miss you so much and all the pit stops in between you end up somewhere around indifference and one you hit indifference you've really made progress!
If the one tablet a night is holding you then so be it. Eventually you'll be able to get off that even if it means tapering it down.

You've done great in a relatively short amt of time. Pat yourself on the back! Much luck and wishing continued success for you.
 
22lbs dude...I wish it was kg. Have put on a few again after my initial success.

Day 2 coming off the last tablet per day. tried to do this so many times over the past month, each time I start falling into a black pit of despair.
I saw another Psychiatrist yesterday, the third in a row to state that I am a "complex case" and have no clear answer for me about whats going on....that I fit multiple diagnoses.
Wants to try me on lithium, I said if I have to choose between neuroleptics and lithium I would choose lithium but hate the idea of either.
Walked out with a sample pack of agomeletine, meant to start tonight.
I was going to try to cold turkey and see if there is light at the end of the nardil withdrawal tunnel but really..... I have know nothing but suffering being medication free, there is no reason to think it will be different this time.
All I can think about is my ex....
I know in my heart that she wasn't the right person for me... but it doesnt stop the pain.
Maybe its not even her that I miss, maybe this is just a manifestation of my depression.
To be honest she pretty much constantly did my head in... yet all I feel is grief and loss

Why does everything always feel wrong? Profoundly fucking wrong. All my jobs, living situations, relationships. I never feel secure, never feel content. its always WRONG!
What is this huge hole inside me that nothing can fill?

My gut instict is to pack my bags and go...another city, another country... but I have done this so many times already...it is not an answer. "Wherever you go, there you are"


I see pretty much zero chance agomeletine will work when countless others have failed.
All these drugs...they take away the essence of being alive...its something you cant quite put your finger on until it comes back...a spark, beauty, something.

What a choice huh? *Rock*-ME-*Hard place*

I have an acid tripp to look forward to in a couple of weeks. ... wow, I just realised that that is all I have to look forward to in my life... sux.
 
Hey, really interested in how you are doing now. I have started withdrawing from Effexor after only taking it a month and after getting it prescribed found nothing but bad reviews on it. I requested Nardil from my psychiatrist though during the session where I was prescribed Effexor after reading it was the end all of SA drugs as I think was stated above as well(maybe). He refused and said there were too many side effects and I hadn't been ran through the whole panel of AD's yet though I have taken atleast 7 different ones. I really need something to work for me, and just wanted to see if you were able to get back to normal or succumbed to taking nardil again.
 
I'm in the process of quitting Nardil too. I basically halved my dose and a few days didn't even take it. I don't know what the hell I'm doing. The only withdrawal effects I'm getting are messed up sleep side effects/unrestful state, which includes some dreaming, but the most painful aspect is the unrestfulness of the sleep. There's a physiological component to the sleep issues, such as being zapped awake. I'm also smoking a fair amount; tobacco is an irreversible inhibitor of MAO-A & MAO-B,* so god only knows of the complication that that introduces into the mix.

Nardil definitely represses the libido, that's coming from me as well as a bunch of online posts. How long until I feel like a clean slate again (especially want to know about libido)?


*

Working with mainstream smoke collected from commercial cigarettes we confirmed that cigarette smoke is a potent inhibitor of human MAO-A and -B isozymes.

Tomas Herraiz, Carolina Chaparro, Human monoamine oxidase is inhibited by tobacco smoke: β-carboline alkaloids act as potent and reversible inhibitors, Biochemical and Biophysical Research Communications, Volume 326, Issue 2, 14 January 2005, Pages 378-386, ISSN 0006-291X, 10.1016/j.bbrc.2004.11.033.
(http://www.sciencedirect.com/science/article/pii/S0006291X04025999)


The correlation between the levels of the βCs norharman (inhibitor of MAO B) and harman (inhibitor of MAO A) in tobacco smoke and the proportion of the inhibited isoenzymes in the human brain measured by PET strongly support the notion that these two βCs are responsible for the inhibition of MAO A and B in human brain from smokers.

Hans Rommelspacher. Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants. Current Topics in Neurotoxicity Volume 1, 2012, pp 115-124


Platelet MAO-B activity, plasma 3,4-dihydroxyphenylglycol, plasma 3,4-dihydroxyphenylacetic acid, and plasma 3,4-dihydroxyphenylalanine concentrations were significantly lower in smokers than in nonsmokers, whereas plasma norepinephrine did not differ.

Ivan Berlin, Sophie Said, Odile Spreux-Varoquaux, Robert Olivares, Jean-Marie Launay, Alain J. Puech. Monoamine oxidase A and B activities in heavy smokers. Biological Psychiatry. Volume 38, Issue 11 , Pages 756-761, 1 December 1995


Inhibitory activity towards monoamine oxidase has been found in a solution of cigarette smoke. The inhibition was irreversible. When tissue slices of rat lung were incubated in the cigarette smoke solution or alternatively, exposed directly to cigarette smoke, monoamine oxidase activities were reduced drastically. Similarly, human saliva after cigarette smoking also exhibits considerable MAO inhibitory activity.

Yu PH, Boulton AA. Irreversible inhibition of monoamine oxidase by some components of cigarette smoke. Life Sci. 1987 Aug 10;41(6):675-82.
 
red22 said:
I'm in the process of quitting Nardil too. I basically halved my dose and a few days didn't even take it. I don't know what the hell I'm doing. The only withdrawal effects I'm getting are messed up sleep side effects/unrestful state, which includes some dreaming, but the most painful aspect is the unrestfulness of the sleep. There's a physiological component to the sleep issues, such as being zapped awake. I'm also smoking a fair amount; tobacco is an irreversible inhibitor of MAO-A & MAO-B,* so god only knows of the complication that that introduces into the mix.

Nardil definitely represses the libido, that's coming from me as well as a bunch of online posts. How long until I feel like a clean slate again (especially want to know about libido)?


*

Working with mainstream smoke collected from commercial cigarettes we confirmed that cigarette smoke is a potent inhibitor of human MAO-A and -B isozymes.

Tomas Herraiz, Carolina Chaparro, Human monoamine oxidase is inhibited by tobacco smoke: β-carboline alkaloids act as potent and reversible inhibitors, Biochemical and Biophysical Research Communications, Volume 326, Issue 2, 14 January 2005, Pages 378-386, ISSN 0006-291X, 10.1016/j.bbrc.2004.11.033.
(http://www.sciencedirect.com/science/article/pii/S0006291X04025999)


The correlation between the levels of the βCs norharman (inhibitor of MAO B) and harman (inhibitor of MAO A) in tobacco smoke and the proportion of the inhibited isoenzymes in the human brain measured by PET strongly support the notion that these two βCs are responsible for the inhibition of MAO A and B in human brain from smokers.

Hans Rommelspacher. Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants. Current Topics in Neurotoxicity Volume 1, 2012, pp 115-124


Platelet MAO-B activity, plasma 3,4-dihydroxyphenylglycol, plasma 3,4-dihydroxyphenylacetic acid, and plasma 3,4-dihydroxyphenylalanine concentrations were significantly lower in smokers than in nonsmokers, whereas plasma norepinephrine did not differ.

Ivan Berlin, Sophie Said, Odile Spreux-Varoquaux, Robert Olivares, Jean-Marie Launay, Alain J. Puech. Monoamine oxidase A and B activities in heavy smokers. Biological Psychiatry. Volume 38, Issue 11 , Pages 756-761, 1 December 1995


Inhibitory activity towards monoamine oxidase has been found in a solution of cigarette smoke. The inhibition was irreversible. When tissue slices of rat lung were incubated in the cigarette smoke solution or alternatively, exposed directly to cigarette smoke, monoamine oxidase activities were reduced drastically. Similarly, human saliva after cigarette smoking also exhibits considerable MAO inhibitory activity.

Yu PH, Boulton AA. Irreversible inhibition of monoamine oxidase by some components of cigarette smoke. Life Sci. 1987 Aug 10;41(6):675-82.
Click to expand...

How'd it go? Hoping to come off Nardil after 3 years on 75 mg and to be honest I'm pretty fucking nervous about having a flowers for algernon regression and loosing all my friends.
 
Hey, OP here, damn this is an old thread.
I'm no longer on Nardil, I finally got off it about 18 months ago.
I had been on almost every drug and nothing else worked until I started clomipramine 250mg per day.
I combine it with Ritalin most days.

Almost no side effects, I went from 97kg on nardil to 79kg now.

Nardil is not worth it
 
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