• N&PD Moderators: Skorpio | someguyontheinternet

Will somone draw this plz!

fastandbulbous said:
Replace the piperidyl group with an N-ethylamino group; beyond that you run a fair chance of altogether abolishing any noticable NMDA-antagonist activity.


So 3-OH-PCE?

Any clue what thats sposed to do for activity if theres a 3-OH present? Or would you think you could assume how it goes with just PCE would be that with the addition of effect 3-OH has on PCP??

Can somone draw it?
 
johanneschimpo said:
^ Do you even know what you're talking about?


Yes, do you??


It say; The N-ethyl analog of PCP (9), PCE, cyclohexamine, CI-400 of Parke Davis and Co.) first appeared in the Los Angeles area about 1969. The initial samples were a wet yellow to brown gum, and were sold and accepted as PCP. The average dose was somewhat smaller than PCP, however, suggesting a higher human potency. This is in keeping with reported animal data7. By 1971 this drug was available as a white solid, superficially indistinguishable from PCP hydrochloride; at no time was it identified other than as PCP.


So what im askin is, can you take whats in italics there, lets say that was 50% the dose vs. PCP, and then take whats known of how 3-OH-PCP supposedly effects, and combine the two to come to a logical and probable?? conclusion that 3-OH-PCE would be greater potency than 3-OH-PCP @ the PCP receptor and equivalent potency @ the mu-receptor??

Or does F&B or somone know something that says PCE SAR data differs widely?
 
Also

did I draw this correctly??

3ohpce1fk.jpg
 
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