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Will L-Tyrosine interact w/ Bupropion

Hypnotik1

Hypnotik1

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I take a fat burner (Xenadrine Ephedra Free) every morning b4 work to give me a lil energy throughout the day.....Its main active ingredient is L-Tyrosine

I just recently started taking Wellbrutrin as a smoking cessation aid....

My understanding of how Bupropion works (correct me if im wrong) is that it acts similarly to Fluoxetine yet targets the dopamine reuptake transporters....

I know L-Tyrosine is to dopamine as 5htp is to serotonin....

So my question is....Will taking thse 2 substances together be equilvalent to serotonin syndrome, or something similar?
 
No, I wouldn't be overly concerned, L-tyrosine isn't like 5-HTP, it's like L-tryptophan. It's the chemical before the rate-limiting step in the synthesis of the neurotransmitter, it's before the chemical bottle-neck if you will.

Though, I'd suspect that a lot of the effect the L-tyrosine is because it has a slight peripheral amphetamine like effect.
 
^^

Good call......I tired half the dosage of the Xenadrine i nornally take while on the Bupropion.....and i did feel overly stimulated and anxious....

But it could be due to the fact that w/in the first few days of Buproprion i feel all the reported side effects for the first week or so....After that i feel normal......I guess ill try it again when the side effects subside.......

But thx for the info:)
 
Keep in mind, it could just be the bupropion that is responsible for these side effects that you are experiencinng and it may have nothing to do with the Xenadrine (L-tyrosine) at all. Of course, it also could be due to the combination of the two, possibly due to additive/synergestic effects or some other interaction between them. I think you have a good plan though - keep the dose of the Xenadrine lower until you see how you react to the bupropion after being on it for awhile...side effects often lesser (or disappear entirely) once your body's "adjusts."

I don't think their are any dangerous interactions between the two though, which I believe is what BilZ0r was saying as well.
 
BilZ0r - did you mean that the only effect of L-tyrosine on the body is the effects of dopamine that can't cross the bbb?
 
No. I was under the impression that Tyrosine, like tyramine, causes the release of noradrenaline peripherally (thought I'm not quite so sure of that now).
 
^^^

Yea i think ur right...... if i understand u correctly

According to my book "Mind Boosters" the conversion of Phenylaline and Tyrosine to Dopamine and Norepinephrine is:

Phenylalnine > Tyrosine > L-Dopa > Dopamine > Norepinephrine > Epineprhine
 
That's certinaly the case, but that's not what I'm talking about (or was talking about)...

What I was saying is that tyrosine, like amphetamine, is a substrate for the noradrenaline transporter, and hence causes the release of noradrenaline.
 
If the levels of dopamine or noradrenaline get high enough, they act as inhibitors of tyrosine hydroxylase (converts tyrosine to DOPA), which as BilZ0r has mentioned, is the rate limiting step.

It's a self regulating negative biofeedback mechanism to prevent excessive amounts of dopamine/noradrenaline from being produced (the tyrosine also has uses in synthesis of various proteins, so you don't want it all to go for neurotransmitter production).

I'm fairly sure that it's only tyramine (4-hydroxyphenethylamine) that acts as an indirect adrenergic agent, otherwise you'd never synthesise any catecholamines, as as soon as the tyrosine hydroxylase got anywhere near tyrosine, there would be noradrenaline released and the enzyme would be inhibited
 
I'm not sure if that logic holds.

All of the monoamines are "amphetamine" like, in regards to the fact that they cause transporter dependent release. The transport of any substrate through the monoamine tranporter leads to release.
 
Yes, I can see that for tyramine, but doesn't tyrosine have an active uptake mechanism in all cells (well all amino acids, as they tend to form the zwitterion at physiological pH, so aren't going to just diffuse through the membrane)? That would indicate that it's passage into cells isn't linked to monoamine release, or cells like liver cells, or various endocrine cells wouldn't be able to transport amino acids across their membrane
 
*shrug* I was looking for something which said that tyrosine was a monoamine transporter substatrate (which I -thought- I had seen), but I couldn't find it... that's why I retracted my statement.
 
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