Stimulants Will I trip hard or pass out need help

[WafflesAreYum]

I'm on 50mg seroquel

I've been doing drugs for a Long time now and I usually mix my seroquel (quantipine) with weed and I get really high unlike a lot of people who do this I have a tolerance to seroquel but I do end up passing out I would like to do this but throw in a 50mg vyvanse to keep me up. Now to what I'm asking I just wanna know if this mix will mock me out or if it will take more weed or if psychosis will awate me tommarow because I was under the impression staying up on seroquel will put you under phycosis I've stayed up on it plenty of times and yes it can so yea
Oh and ps I know that 50mg vyvanse will keep me up when combined with seroquel yes I know seroquel is supposed to put you down off uppers but that has never worked for me vyvanse seems to not get calmed down by the seroquel

So

Will I pass out

Will weed make this experience better

Oh and I will toke up a few times during the night and not with either of the pills

 

[cj]

Uhh well seroquel is an anti-phycotic so no staying awake while on it will not make you phycotic in theory anyway. I have zero experience with seroquel. Honestly if you must tae the seroquel then lower the dose to stay awake instead of the vyvanse.

 

[laCster]

Seroquel will antagonize the effects of amphetamine, literally canceling the two out if taken together. In addition if you take an amphetamine with most atypical antipsychotics, you're highly liable to experience akathisia, if I'm not mistaken.

Many atypicals - or at least ziprasidone and quetiapine - act as alpha 1 and alpha 2 antagonists. Since the alpha 2 adrenergic receptor is an autoreceptor it actually promotes the release of adrenaline and noradrenaline when antagonized. Because the alpha 1 receptor is being blocked by the neuroleptic, the only adrenergic receptors available for binding to these catecholamines are the beta 1, 2, and 3 receptors. So what you have is considerable alpha 1 antagonism and unopposed beta receptor activation. This, or so my hypothesis goes, is the cause of akathisia. This hypothesis finds support in the fact that propranolol, clonidine, and other substances which reduce the activation of the beta receptors can alleviate or bring akathisia entirely to an end.

If you add amphetamine to the mix while you're already experiencing akathisia... well, god help you. That's going to be some terrifying shit.

And no, neuroleptics are almost certainly not going to improve the high if taken just once the night before. They antagonize D2 autoreceptors as well as postsynaptic D2 receptors, meaning that they cause the dopamine storage vesicles to disgorge all their dopamine upon unavailable receptors (on account of the neuroletpic). That means less dopamine available the next day for the amphetamine to release into the synapse. If you were to take a neuroleptic on a long-term basis on the other hand, that would sensitize post-synaptic D2 receptors and increase (probably) the hedonic effect of amphetamine, but I think most atypical antipsychotics - and definitely quetiapine - don't cause D2 upregulation (because they disassociate from the receptor so quickly?).

 

[WafflesAreYum]

When I take vyvanse with seroquel I still don't feel like I am in reality what effects does seroquel block from the vyvanse

 

[WafflesAreYum]

Ill have akathisia restless leg syndrome like on benodryl