Confessions of a triplicated addiction, the Internet, Chemistry, and ...Chemdraw.
Well fuck, so I read *who knows what* when i woke up which prompts me to open up chemdraw and do *whatever it was*. Well that led to something, and something and..
ended up looks like I got a post full of ranting and guessing and questions but shit i forgot the real reason i was going to post in the first place. But, I found a bunch of information somehow useful to me and well I sat for hours and hours, uh, so yeah, here's some "stuff"?! lol. Afterwards I looked at it, thinking oh god, well i should make a separate audio only thread and then a something else thread or something but fuck it i'm tired now. Argh.
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I got the lucky chance to taste TMT or alpha,N,N-trimethyltryptamine once, orally, I forget the dose.. but it was maybe around 100mg or so. I've never tried MiPT, although have had 4-HO and AcO-MiPT and 5-MeO-MiPT.
With TMT I got some brigher colors, mild visuals (would dose higher IMO), and a very good body buzz, and audio distortion that reminded me of DiPT. But - i'm sensitive as fuck to any of these tryptamines that distort audio (only to the audio effects) for some reason compared to most everyone else. I haven't had MiPT but I bet i'd get some audio distortion - it seems anything with an isopropyl group (or, probably has to have the shape at least) does that. Each has their own 'flavour' of audio distortion, all lowering the pitch and screwing up linearity and harmonics but a little differently, and the audio effect seems totally separated from the psychedelic effect.
Anyway.. DiPT is the biggie of course, the one that's strong enough for most people to notice it. 5-MeO-DiPT seems to have a very very similar "flavour" to DiPT in the way sound is distorted. One time I kept redosing on 5-MeO-DiPT the entire night, whenever i'd start to come down, take another 10mg. Well by morning, psychedelic effects were gone but the audio was strong, DiPT like strong (maybe compared to DiPT at 40mg-45mg for me). For some reason 4-HO-DiPT does do it too, but just barely detectable really..
Now 4-AcO or HO-MiPT both distort audio, not much (but i've done the same thing as 5-meo-dipt noticed redosing boosted the audio distortion), but the "flavour" is definitely different. Harmonics are fucked up like the DiPT's but just fucked in a ...different way. Too bad I haven't tasted MiPT, because from what I read and now that i've had TMT (see pic), i'd bet money (well not much money) that i'd get some good audio distortion with MiPT and maybe would've taken the dose up higher too. I would guess MiPT's 'flavour' would be more like TMT's, still different but, just more like TMT, just because the molecules look so similar. I drew these in chemdraw, but deleted the Nitrogen's just so its easier to see i guess.
DMT, tried it (MANY TIMES! w00t), then there's homo-DMT, in some study (i have the file somewhere..) comparing some tryptamines it shows HDMT to be equal potent to DMT. HDMT is DMT but with an extra carbon chain between the N,N-DMT and the indole. Ignoring the nitrogens, you could say MiPT is just TMT with an extra carbon chain between the indole and where the uhm.. isopropyl and methyl split ..thingie is (since the N's are in the wrong spot don't know how else to say it just look at the image hehe).
I drew another DMT like molecule but made it one less carbon, actually I did not know that it was Gramine til I looked it up!
Well I don't know anything about gramine so i googled it,
From Tihkal:
Well fo' shizzy? suprise, there's that homo-DMT right there in Tihkal saying 70mg IM doses didn't do anything.. But I have some file somewhere with a chart, I don't know if it was receptor binding or animals but it showed it to be equal potent to DMT. I'll have to find that file..
I guess i'm just staring at these things, trying to figure out why they do what they do just by some patterns. Since I get audio distortion from TMT, well that overall shape of that part of the molecule must have more to do with it than where the nitrogen's are (or if there are any at all). Now, if Shulgin is right and HDMT is inactive, maybe its because if you ignore the nitrogen it looks kinda like a N-isopropyltryptamine - which is inactive like most mono substituted N,N tryptamines. NSBT and NTBT (taken out of Tihkal) are said to be a couple rare known active mono substituted tryptamines so I punched those into chemdraw also. I look at those two, and NSBT just looks like HDMT but with a methyl/ethyl and the N in a different spot. Methyl / Ethyl? MET.. orally active.. different effects.. NTBT kinda looks like HDMT but since the nitrogen is "where it usually is supposed to be" if you ignore the nitrogen its got that extra carbon chain going to a trimethyl thingamubugger.
So out of these the ones known to be orally active are a,N,N-TMT, a-MT, MiPT, NSBT, NTBT. Now these Nitrogens and where they're at, well I got a lot of reading to do thats for fuckin' sure. Interesting shit, but its like learning bits and pieces of C++ but not knowing whats basically happening (hmm.. SAR stuff and electrons and receptors and BACON!)
On that BL thread "Tihkal revised" and in at least one paper i've seen 5-MeO-NMT compared and looks like its about equal in potency. Anyone know if plain 5-MeO-T is active? This paper shows a number (well lots of them, different receptors) similar to serotonin, binding to 5HT2A, would be interesting to know what it does (smoked/IM/IV).
Surfing around more i found this,
Ah, didnt even notice that the first thing said they are talking about 5-MeO-tryptamine. I pasted it here because of the last part 5-MeO-gramine being active.
Now all of these have audio distortion (except for the two on the bottom):
It seems like the requirement is, at least for all but the top two, that there's gotta be something that just looks like an N-methyl-N-isopropyl, or diisopropyl (and possibly ethyl/isopropyl? I haven't tried EiPT), but... the Nitrogen doesn't have to be there (where one is in MiPT anyway). a,N,N-TMT "looks" like it has that pattern and it definitely does have audio distortion. But what about the two on the top? 2,N,N-DMT and 2,N,N-DET. Is there some parts swinging around in some certain pattern with those that just fit into these mystery audio receptors (well, audio something!)?
DiPT is the most potent known auditory distorter, i'm sure a few things could be done to make that thing a totally inactive psychedelic but still alter audio.
***
Anyway - blah blah blah. a,N,N-TMT seemed like a good psychedelic, i've heard the word on the street it gets real good around 180mg I think.
Its a simple reaction from AMT, but shit, use some acealdehyde instead and I bet the a-methyl-N,N-DET version would rock too! Hmm wonder about the potency though?
Speaking of potency my guess is 5-MeO-a,N,N-TMT (made from that shitty 5-MeO-AMT) would be good and plenty active too. Could also do the higher alkyl's -DET etc.
Well fuck, so I read *who knows what* when i woke up which prompts me to open up chemdraw and do *whatever it was*. Well that led to something, and something and..
ended up looks like I got a post full of ranting and guessing and questions but shit i forgot the real reason i was going to post in the first place. But, I found a bunch of information somehow useful to me and well I sat for hours and hours, uh, so yeah, here's some "stuff"?! lol. Afterwards I looked at it, thinking oh god, well i should make a separate audio only thread and then a something else thread or something but fuck it i'm tired now. Argh.
----
I got the lucky chance to taste TMT or alpha,N,N-trimethyltryptamine once, orally, I forget the dose.. but it was maybe around 100mg or so. I've never tried MiPT, although have had 4-HO and AcO-MiPT and 5-MeO-MiPT.
With TMT I got some brigher colors, mild visuals (would dose higher IMO), and a very good body buzz, and audio distortion that reminded me of DiPT. But - i'm sensitive as fuck to any of these tryptamines that distort audio (only to the audio effects) for some reason compared to most everyone else. I haven't had MiPT but I bet i'd get some audio distortion - it seems anything with an isopropyl group (or, probably has to have the shape at least) does that. Each has their own 'flavour' of audio distortion, all lowering the pitch and screwing up linearity and harmonics but a little differently, and the audio effect seems totally separated from the psychedelic effect.
Anyway.. DiPT is the biggie of course, the one that's strong enough for most people to notice it. 5-MeO-DiPT seems to have a very very similar "flavour" to DiPT in the way sound is distorted. One time I kept redosing on 5-MeO-DiPT the entire night, whenever i'd start to come down, take another 10mg. Well by morning, psychedelic effects were gone but the audio was strong, DiPT like strong (maybe compared to DiPT at 40mg-45mg for me). For some reason 4-HO-DiPT does do it too, but just barely detectable really..
Now 4-AcO or HO-MiPT both distort audio, not much (but i've done the same thing as 5-meo-dipt noticed redosing boosted the audio distortion), but the "flavour" is definitely different. Harmonics are fucked up like the DiPT's but just fucked in a ...different way. Too bad I haven't tasted MiPT, because from what I read and now that i've had TMT (see pic), i'd bet money (well not much money) that i'd get some good audio distortion with MiPT and maybe would've taken the dose up higher too. I would guess MiPT's 'flavour' would be more like TMT's, still different but, just more like TMT, just because the molecules look so similar. I drew these in chemdraw, but deleted the Nitrogen's just so its easier to see i guess.
DMT, tried it (MANY TIMES! w00t), then there's homo-DMT, in some study (i have the file somewhere..) comparing some tryptamines it shows HDMT to be equal potent to DMT. HDMT is DMT but with an extra carbon chain between the N,N-DMT and the indole. Ignoring the nitrogens, you could say MiPT is just TMT with an extra carbon chain between the indole and where the uhm.. isopropyl and methyl split ..thingie is (since the N's are in the wrong spot don't know how else to say it just look at the image hehe).
I drew another DMT like molecule but made it one less carbon, actually I did not know that it was Gramine til I looked it up!
Well I don't know anything about gramine so i googled it,
From Tihkal:
Well fo' shizzy? suprise, there's that homo-DMT right there in Tihkal saying 70mg IM doses didn't do anything.. But I have some file somewhere with a chart, I don't know if it was receptor binding or animals but it showed it to be equal potent to DMT. I'll have to find that file..
I guess i'm just staring at these things, trying to figure out why they do what they do just by some patterns. Since I get audio distortion from TMT, well that overall shape of that part of the molecule must have more to do with it than where the nitrogen's are (or if there are any at all). Now, if Shulgin is right and HDMT is inactive, maybe its because if you ignore the nitrogen it looks kinda like a N-isopropyltryptamine - which is inactive like most mono substituted N,N tryptamines. NSBT and NTBT (taken out of Tihkal) are said to be a couple rare known active mono substituted tryptamines so I punched those into chemdraw also. I look at those two, and NSBT just looks like HDMT but with a methyl/ethyl and the N in a different spot. Methyl / Ethyl? MET.. orally active.. different effects.. NTBT kinda looks like HDMT but since the nitrogen is "where it usually is supposed to be" if you ignore the nitrogen its got that extra carbon chain going to a trimethyl thingamubugger.
So out of these the ones known to be orally active are a,N,N-TMT, a-MT, MiPT, NSBT, NTBT. Now these Nitrogens and where they're at, well I got a lot of reading to do thats for fuckin' sure. Interesting shit, but its like learning bits and pieces of C++ but not knowing whats basically happening (hmm.. SAR stuff and electrons and receptors and BACON!)
On that BL thread "Tihkal revised" and in at least one paper i've seen 5-MeO-NMT compared and looks like its about equal in potency. Anyone know if plain 5-MeO-T is active? This paper shows a number (well lots of them, different receptors) similar to serotonin, binding to 5HT2A, would be interesting to know what it does (smoked/IM/IV).
Surfing around more i found this,
Ah, didnt even notice that the first thing said they are talking about 5-MeO-tryptamine. I pasted it here because of the last part 5-MeO-gramine being active.
Now all of these have audio distortion (except for the two on the bottom):
It seems like the requirement is, at least for all but the top two, that there's gotta be something that just looks like an N-methyl-N-isopropyl, or diisopropyl (and possibly ethyl/isopropyl? I haven't tried EiPT), but... the Nitrogen doesn't have to be there (where one is in MiPT anyway). a,N,N-TMT "looks" like it has that pattern and it definitely does have audio distortion. But what about the two on the top? 2,N,N-DMT and 2,N,N-DET. Is there some parts swinging around in some certain pattern with those that just fit into these mystery audio receptors (well, audio something!)?
DiPT is the most potent known auditory distorter, i'm sure a few things could be done to make that thing a totally inactive psychedelic but still alter audio.
***
Anyway - blah blah blah. a,N,N-TMT seemed like a good psychedelic, i've heard the word on the street it gets real good around 180mg I think.
Its a simple reaction from AMT, but shit, use some acealdehyde instead and I bet the a-methyl-N,N-DET version would rock too! Hmm wonder about the potency though?
Speaking of potency my guess is 5-MeO-a,N,N-TMT (made from that shitty 5-MeO-AMT) would be good and plenty active too. Could also do the higher alkyl's -DET etc.
