MobiusDick
Bluelighter
It's been a while since I've posted, but this topic needs to be discussed so some of the long time users and addicts will understand what's going on! It is not the drugs that have changed, it is your physiology that has! I must hear this 5-10 times a day: "I used to get so high on those. They've changed the way they make them and they don't get you as high." Well, there is some truth with changes in how pills are made in the pharmaceutical industry, as they are constantly tinkering with the pill matrix to keep people from being able to inject it-even at the expense of fucking over the chronic pain patient by changing the steady plasma levels that make some of the sustained release pills so appealing to people taking them as directed. The new pills have plasma levels that are all over the place, or don't even completely dissolve po so junkies won't be able to get a buzz, They have pushed it too far and there are those of us who are trying to make sure the DEA holds up its legally required end of its bargain, as they are forbidden from practicing medicine; and that is exactly what they are doing by deciding what medications can be prescribed by your doctor.
But the drugs have not changed as much as your physiology has changed over 5, 10, 15, 20 or 30 years of daily use. Some drugs -for example, methadone-change your physiology far more rapidly and far greater than other drugs like hydrocodone. I know that when Knoll was making Dilaudid K-4 tablets prior to 1990, the tablets were still the only hypodermic tablet still on the market, I would have raccoon eyes for days from 2 of the yellow K-4's. But, even before Abbott bought them, started putting A-4 on them and started putting insolubles in the pills so they were truly no longer hypodermic, the days where 2 of the pills would get me nodding were long in the past. If anyone ever had any doubts, in 2007, I emptied a 250 mg vial of Sigma Hydromorphone HCl into a vial with 2 cc's of H20, drew it up in a 3 cc syringe and shot it in a large vein, and it still was not as good as the 2 K-4's of the early days of my drug use. So realize that every time you get high, your brain chemistry is altered. Dopamine neurons may be dying or it may be something else. Just ask someone who has used for 25 years what withdrawal is like compared to 5 or 10 years ago; to someone who has been using 10 years, the habit of 7 years ago was nothing. Most of you could not handle your first habit, but compared to what it would be like 30 years later, my first habit was mere annoyance-a joke. The withdrawal syndrome increases exponentially for all of us. You may think it cannot get any worse, but let me promise you, it can and it will. Look in a pharmacology book or the PDR. Read the symptoms of opioid abstinence. You will eventually have each and every one of those symptoms you see-no exceptions. I guarantee it.
MobiusDick
But the drugs have not changed as much as your physiology has changed over 5, 10, 15, 20 or 30 years of daily use. Some drugs -for example, methadone-change your physiology far more rapidly and far greater than other drugs like hydrocodone. I know that when Knoll was making Dilaudid K-4 tablets prior to 1990, the tablets were still the only hypodermic tablet still on the market, I would have raccoon eyes for days from 2 of the yellow K-4's. But, even before Abbott bought them, started putting A-4 on them and started putting insolubles in the pills so they were truly no longer hypodermic, the days where 2 of the pills would get me nodding were long in the past. If anyone ever had any doubts, in 2007, I emptied a 250 mg vial of Sigma Hydromorphone HCl into a vial with 2 cc's of H20, drew it up in a 3 cc syringe and shot it in a large vein, and it still was not as good as the 2 K-4's of the early days of my drug use. So realize that every time you get high, your brain chemistry is altered. Dopamine neurons may be dying or it may be something else. Just ask someone who has used for 25 years what withdrawal is like compared to 5 or 10 years ago; to someone who has been using 10 years, the habit of 7 years ago was nothing. Most of you could not handle your first habit, but compared to what it would be like 30 years later, my first habit was mere annoyance-a joke. The withdrawal syndrome increases exponentially for all of us. You may think it cannot get any worse, but let me promise you, it can and it will. Look in a pharmacology book or the PDR. Read the symptoms of opioid abstinence. You will eventually have each and every one of those symptoms you see-no exceptions. I guarantee it.
MobiusDick
