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Why to benzos keep me awake(it is a ADD question)

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FPU4eva

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Feb 27, 2008
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so 2 years ago I went threw a hellish Lyrica withdrawl(was taking 1.3 grams a day) they pumped me full of valium which just made the withdrawl worse(hell i was catonic for a week in the ER) but since then my back nerves if anyone slaps me hurts soo much, and when i take any type of benzo it just keeps me awake and gittery? did I mess up my GABA receptors? also im on low dose lyrica now with suboxone for anxiety and my back no longer hurts when it gets slapped

let me no if this is the right place I just thought maybe sense I fried my receptors out benzos reverse action on me! thanks internet gurus!
 
villian said:
paradoxical reaction
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Clearly, but I think he's looking for the reasons for it.

Unfortunately, this would involve a pretty extensive discussion of genetics, serotonin/GABA/choline levels, etc..

There is no blanket answer AFAIK.

The more specific question would be can Lyrica withdrawal be so severe so as to invert his receptors?
 
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Unfortunately, this would involve a pretty extensive discussion of genetics, serotonin/GABA/choline levels, etc..

There is no blanket answer AFAIK.

The more specific question would be can Lyrica withdrawal be so severe so as to invert his receptors?
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We should instead admit that human understanding of neurology is not yet sufficiently advanced to explain why one would exhibit a paradoxical reaction to benzos following a brief course of high-dose treatment; we can't just dump in every neurochemical concept in sight.

However, with amphetamine addiction, we do see paradoxical sensitization to negative side-effects (as tolerance to euphoria grows). Perhaps we're seeing something analogous here, but I'm at a loss for what the possible mechanisms could be.

ebola
 
Inedible said:
Inverting doesn't make sense; you'd have a few more problems on your hands if your receptors were "inverted."
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I'm sorry I was sloppy with my words here. I must admit "receptor inversion" is not technically the correct term here and I realize now that it sounds at odds with what I meant.

A harsh withdrawal might possibly produce a partial "reverse tolerance" where the side-effects are amplified but the "regular effects" are left unchanged or reduced. By invert, I meant flipped or switched.
 
Here's a thread which can better explain the workings of benzos thanks to kokaino.

Clonazepam is the only benzodiazepine that does this to me regularly and at all (every other benzo I have taken has at least 'worked', whether or not i enjoyed it, although I am going to stop using lorazepam at all ever purely because of how much it resembles clonazepam to me at times).
 
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Captain.Heroin said:
Here's a thread which can better explain the workings of benzos thanks to kokaino.

Clonazepam is the only benzodiazepine that does this to me regularly and at all (every other benzo I have taken has at least 'worked', whether or not i enjoyed it, although I am going to stop using lorazepam at all ever purely because of how much it resembles clonazepam to me at times).
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Could you clarify a bit?

To summarize the post, Clonazepam has a high affinity for α2 and α3 but a weak affinity for α1 and β3.

So could one conclude that it is the lack of sedation and hypnotic properties that lead one to act out their uninhibited behavior? A bit like a raging alcoholic?
 
I am a benzo addict (no longer on them, though). They have the paradoxical reaction of keeping me awake, almost spun out, even. Especially with alprazolam.
 
well benzos dont make everyone tired although it does for most people, if you don't take an extremely high dose it can make you feel real social and confident and you also mentioned you have ADD, people with ADD need alot more to bring them down, and alot of the times the downers make them alot less down than to they do to people without ADD.
 
killakillakam said:
Could you clarify a bit?

To summarize the post, Clonazepam has a high affinity for α2 and α3 but a weak affinity for α1 and β3.

So could one conclude that it is the lack of sedation and hypnotic properties that lead one to act out their uninhibited behavior? A bit like a raging alcoholic?
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Paradoxical reactions to benzos can happen with any benzodiazepine and is based more on individual unique differences in our biopharmacology.

I linked the thread to help people better understand how benzodiazepines work on a pharmacodynamics.
 
i never said I had ADD lol i meant advanced drug discussion but idk its weird because the lyrica still works for me and puts me out but the benzos dont, o well i never liked benzos much anyway but consider lyrica my drug of choice right next to tramadol
 
i never said I had ADD lol i meant advanced drug discussion but idk its weird because the lyrica still works for me and puts me out but the benzos dont, o well i never liked benzos much anyway but consider lyrica my drug of choice right next to tramadol.
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Lyrica is not cross-tolerant with benzodiazapines, as it has a distinct mechanism (calcium-channel blocker/'fucker').

ebola
 
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