It says everywhere that modafinil is virtually insoluble in anything ingestible. But this patent (https://patents.google.com/patent/US6919378B2/en) says: "...A mixture of 95 mL of PEG-400 and 5 ml of benzyl alcohol was stirred at room temperature until homogeneous. To a separate container, 0.1 gram of modafinil was weighed and 1 mL of the mixed solvent was added with stirring and heating to 55-60° C. The solution was allowed to cool to room temperature and any undissolved solid was removed by filtering the solution. In the case of a viscous solution or a solution that solidifies at room temperature, warming until a freely flowing solution was obtained and then filtration gave a solution free of particulate matter.
The solubility of modafinil was 61 mg/ml, as measured by HPLC..." Does this mean that if someone gets the chemical modafinil and swallows such a solution, they will get the effectiveness of a pharmaceutical-prepared tablet? My recollection is that in the past, modafinil could be obtained in the form of fairly large crystals or powder, but was not effective when ingested.
The solubility of modafinil was 61 mg/ml, as measured by HPLC..." Does this mean that if someone gets the chemical modafinil and swallows such a solution, they will get the effectiveness of a pharmaceutical-prepared tablet? My recollection is that in the past, modafinil could be obtained in the form of fairly large crystals or powder, but was not effective when ingested.