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Why does grapefruit juice help

If I remember correctly I believe it inhibits an enzyme in your liver/stomach from breaking it down quickly.
 
^^

It doesn't "help" a roll, meaning that drinking grapefruit juice isn't going to get you any higher. But grapefruit juice does contain anti-oxidants (vitamin C) which are a good thing to take if you are going to be taking a substance that could be neurotoxic.
 
^
People used to think that grapefruit juice inhibited an enzyme that broke down MDMA, meaning that you'd roll harder if you took grapefruit juice. Current thinking seems to be that any effect would be so small that you wouldn't notice it (see thedea.org's site).

So yeah, you're right that it's basically only the anti-oxidants that would help.
 
grapefruit juice inhibits CYP3A4 enzyme. Im not sure if MDMA is broken down by that enzyme or not. if it is - then yes you will get more effects from a dose. if not - then the added vitamins etc sure wouldnt hurt.


ive only ever used grapefruit juice to potentiate codeine - and the effects are small but noted.
 
Whatever you do, dont eat a ton of pineapple. Makes it feel like your tongue was scraped raw.

I will try the grapefruit thing next time i get some.
 
TrypstaEMS said:
why does grape fruit juice help your roll?
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Because someone has told you that it will help so you're expecting a better roll and consequently you have a better roll.

In other words, placebo.
 
JimiHawK* said:
grapefruit juice inhibits CYP3A4 enzyme. Im not sure if MDMA is broken down by that enzyme or not. if it is - then yes you will get more effects from a dose. if not - then the added vitamins etc sure wouldnt hurt.


ive only ever used grapefruit juice to potentiate codeine - and the effects are small but noted.
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isnt mdma broken down by CYP2D6 or something like that?
 
when the seretonin in your body begins to depleat (rolling nasty ass balls) your seretonin receiver thingies start to take in dopamine instead of seretonin which is okay for the receiver things because it doesnt know the diffrence, but its really bad for your synapsis because the dopamine breaks down and oxidizes into hydrogen-peroxide...BAD!! hydrogen-peroxide is a neurotoxin and will slowly destroy your synapsis....so the vitamin-c (an anti-oxidant) does just that...helps prevent the oxidation of the dopamine to further prevent the production of hydrogen-peroxide...not bad for a 17 year old heh%)
 
nocturnal_euphoria said:
when the seretonin in your body begins to depleat (rolling nasty ass balls) your seretonin receiver thingies start to take in dopamine instead of seretonin which is okay for the receiver things because it doesnt know the diffrence, but its really bad for your synapsis because the dopamine breaks down and oxidizes into hydrogen-peroxide...BAD!! hydrogen-peroxide is a neurotoxin and will slowly destroy your synapsis....so the vitamin-c (an anti-oxidant) does just that...helps prevent the oxidation of the dopamine to further prevent the production of hydrogen-peroxide...not bad for a 17 year old heh%)
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Wouldn't hydrogen peroxide eat through your brain tissue and leave you with nothing but a skull full of smoke?
 
Isn't the real danger if the hydrogen peroxide drips out of your brain and down your spine before draining away through your anus? Causing severe burns to the rectum?
 
Believe that grapefruit juice may actually do little for the experience its acidity affecting uptake and negating most benefits to be had by its enzyme inhibiting actions.
 
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the link to the original article doesn't work anymore, but here's the text

Originally Posted by Rueters
WASHINGTON (Reuters) - U.S. researchers said they have identified the compound in grapefruit juice that affects how some drugs are absorbed in the body and said on Tuesday it might be used to help lower dosages for some patients.


Grapefruit juice is known for its effects on drug metabolism and is avoided by some patients while other deliberately take their drugs with the juice.

The reason is an intestinal enzyme called CYP3A, which partially destroys drugs as they are absorbed. Grapefruit juice, like no other fruit juice, interferes with CYP3A, so the body ends up absorbing more of the drug.

Dr. Paul Watkins of the University of North Carolina at Chapel Hill and colleagues say they have identified the substance in grapefruit juice that is responsible -- furanocoumarin.

"It should now be possible to market the furanocoumarin-free grapefruit juice to patients who would otherwise need to avoid grapefruit," Watkins said in a statement.

"In addition, it should be possible to screen new foods for the potential for drug interactions by determining whether they contain furanocoumarins," Watkins said.

"Finally, it may be possible to add furanocoumarins to formulations of certain drugs that tend to be poorly or erratically absorbed to improve their oral delivery."

To test the theory that furanocoumarin was the responsible compound, Watkins and colleagues filtered it out grapefruit juice, which they discovered was then less bitter but otherwise unaltered.

Then they tested 18 men and women taking various drugs on a regular basis including aspirin and birth control pills.

Each fasted in the hospital and got a single dose of the blood pressure drug felopidine, sold under the brand name Plendil, along with either normal grapefruit juice, furanocoumarin-free juice or orange juice.

They then ate and drank normally and blood was taken regularly all day.

In each volunteer, the normal grapefruit juice made between 6 percent to 230 percent more Plendil available in the blood, the researchers reported in the American Journal of Clinical Nutrition. The furanocoumarin-free grapefruit juice and orange juice had no such effect, they reported.
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Ismene said:
Wouldn't hydrogen peroxide eat through your brain tissue and leave you with nothing but a skull full of smoke?
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lol it doesnt produce massive amounts... like very small amounts...i just researched this...it was on erowids. I dont know from person research as im no neurologist or n e of that lol....its just what i read
 
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