First off I want to say that this problems just exist with me and that my first trips were always without too much bodyload beside dysphoria maybe on comeup. 2c-e sucked for the first and on the last time for me. It was like my gi-tract was closed and gases were building up and I couldn't let them out till I came down.
Yes, I tend to have gi-issues with cannabis in general but it goes away when I'm sober. But even if I don't use any cannabinoid to combo I still have these issues. Iirc on the comedown it felt like my gi-tract is moving. It may be psychosomatic on the comedown because of the bad trip once but you know it feels real for me in that situation. The thing is after that I didn't use psychedelics for a while, like over a half year at least and then tried 15mg of 4-aco-mipt in the summer and also felt weak during the trip and just slightly like that feeling described.
I'm not sure what's happening. I never tripped too often, I always let a good amount of time between my trips. When I tripped I always tried to make the most of it, that's why I combined with cannabinoids like 250. On combination you needed way less amount to have a very intense mind trip. I always had the goal to understand more about life and I think I reached my goal of enlightening by this way. After that particular trip, I did this combo with some friends and it worked the same way for them but at that day the first bad comedown happened. I actually didn't want to trip at that day, I feel like I don't need to do psychedelics anymore because life is a way more interesting trip.

BUT I still tried four things after that. The time with the 122 badtrip, a big pause after that, my last time 2c-e as described at the beginning, 4-aco-mipt in a summer which was okay but felt different than before and 25b-nbome some weeks ago which was a very nice and easy trip without bodyload beside that there was a strange feeling on my right front side in the height of the lower end of the liver. I'm not sure how to describe it, it felt acidy, like a cool burning. I don't think it's important. Trips were never without any bodyload at all so that was no real problem for me.
I don't know but I don't have any goal any more in trips. I don't see a reason to do them beside curiosity. Psychedelics are powerful tools for personal growth. I'd like to try 25c and 25i low dosed, too because 25b already felt like a tryptamine instead of phen.
This all could be psychologically and the bad trip contributed to it but it's really happening at the comedown so it's real stress for me.