Which drugs do SSRIs prevent effects?

[Blue_Phlame]

Besides MDMA, MDA, & MDEA etc. which other drugs have their effects almost completely cancelled out by having an SSRI in the system?
I have already read this thread and there are only a few chemicals that are described. I'm particularly interested in RCs but any other list would be appreciated.

 

[Allein]

Without stating the obvious I'd come it it the other way if the recreational drug you are planning to take relies in anyway on serotonin then if your on and SSRI its not going to work very well.

So MDAI, 6&5APB, there may well be others I'm not up on Eric latest creations, some reaction may well be unknown since some of these are new chemicals, you will have to investigate the less obvious ons on a case by case basis.

You might also want to think about the comedown off of any drugs and how that may affect you as you must be on the SSRI for a reason so taking a whole shit pile of stimulants may not be such a great idea 24hrs after, however attractive it might seem before hand .

 

[F1n1shed]

You can still get high on many drugs, and that list you have has some false interactions. It is saying you can take cocaine with your SSRI, but these two chemicals do have an interaction. The cocaine seems to get very strong, and you get much more anxious . Not to mention it can cause a very dangerous heart problem and so on. You can still get high on most opiates, weed, most amps. Only thing you can't get high on is the serotonergic drugs, but fuck those drugs. They are a recipe for depression

 

[i against i]

They are a recipe for depression

trueeeee this.

 

[Sepher]

There is evidence that some SSRIs can diminish the effects of some opiates because they inhibit the CYP2D6 enzyme responsible for metabolisation to morphine. I think that mainly applies to codeine and codeine variants like oxycodone and hydrocodone, but you'd need someone more knowledgeable than me to expand on that and give you a full list of opiates affected by which specific SSRIs. The opioid tramadol would also be affected as it's metabolised by the same enzyme.

 

[effie]

^ v true - there is a good CYP-450 chart here which might help, not got time to check it over right now though.. it's an excellent chart in general though

Anything serotonergic is going to be affected, and the points about the come-down not being good if you are being treated for depression are excellent ones. Even non-serotonergic come downs are bad, as you don't really want to be dopamine depleted as well as depressed...

 

[SpunkySkunk347]

Well, I believe most SSRIs and a few SNRIs will prevent the effects of oxycodone by inhibiting the enzymes which metabolize oxycodone into oxymorphone (and perhaps OC's other more potent metabolites).
A few years ago I was on either 150mg venlafaxine or 30mg of paroxetine a day (can't remember which one, I've been off and on so many anti-depressants) and clonazepam -- when I took 20mg of oxycodone it did nothing for me at all.

However, a few times when I was on anti-depressants, I found that they improved the quality of hydrocodone's euphoria, but the dose of hydrocodone I needed to take was much higher (like 45-50mg with zero opiate tolerance)

^ v true - there is a good CYP-450 chart here which might help, not got time to check it over right now though.. it's an excellent chart in general though

Anything serotonergic is going to be affected, and the points about the come-down not being good if you are being treated for depression are excellent ones. Even non-serotonergic come downs are bad, as you don't really want to be dopamine depleted as well as depressed...

That chart is very basic, and it leaves out the secondary enzymes for a lot of different drugs. Oxycodone for example is a substrate of both CYP2D6 and CYP3A4, but oxycodone is only listed under CYP2D6

 

[effie]

^ Haha fair enough, if you have a better chart let us know and we can replace it!

 

[Allein]

They are a recipe for depression

I totally disagree they may be a recipe for a few days of feeling down but there is no evidence that IO have ever seen, thats using MDMA (becuase that's really what we are talking about here) leads to depression.

That whole augment is based on depression being linked to serotonin and the lack there of in th brain and that long term use of MDMA or similar drugs reduce the level of serotonin in the brain long term. If this were the case then all a large number of people suffering from depression who have a history of regular MDMA use would be curred by taking an SSRI.

But there is no evidence to show that to be the case.

There is a massive difference between feeling low for a few days after taking MDMA and actually suffering from depression believe me I have experience of both in abundance.

 

[Pjkt2501]

Sorry for straying OT, but I'm with atm23 here - my depression isn't a result of MDMA usage (been present as long as I can remember.. sort of, I can kinda remember when it properly began, but I was always an odd child), and MDMA hasn't worsened my depression long-term. Sure I've had some of the 'suicide-tuesdays' but hey, that's the game we play. Considering that it's winter, I'm in quite good spirits, and I've eaten roughly a gram of good MDMA (reagent tested) in a bit over a week (well, 2 weeks ago to last weekend).

Opiates have done more to change my brain and body chemistry for the worse than MDMA has.

 

[Blue_Phlame]

^ v true - there is a good CYP-450 chart here which might help, not got time to check it over right now though.. it's an excellent chart in general though

Anything serotonergic is going to be affected, and the points about the come-down not being good if you are being treated for depression are excellent ones. Even non-serotonergic come downs are bad, as you don't really want to be dopamine depleted as well as depressed...

Thanks for the link effie! I'll post the PDF file here for posterity. PDF

 

[Supeudol]

Well, I believe most SSRIs and a few SNRIs will prevent the effects of oxycodone by inhibiting the enzymes which metabolize oxycodone into oxymorphone (and perhaps OC's other more potent metabolites).
A few years ago I was on either 150mg venlafaxine or 30mg of paroxetine a day (can't remember which one, I've been off and on so many anti-depressants) and clonazepam -- when I took 20mg of oxycodone it did nothing for me at all.

However, a few times when I was on anti-depressants, I found that they improved the quality of hydrocodone's euphoria, but the dose of hydrocodone I needed to take was much higher (like 45-50mg with zero opiate tolerance)


That chart is very basic, and it leaves out the secondary enzymes for a lot of different drugs. Oxycodone for example is a substrate of both CYP2D6 and CYP3A4, but oxycodone is only listed under CYP2D6

WOW! So this whole time while I've been on and off Antidepressants over the course of 8 years (almost 9 years) my opiate dosing has been dulled, or is that why I can't get any rush or much
euphoria anymore? I especially notice this with Oxycodone now, yet I never used to at all. I remember being on Cipralex 20mg/day or Paxil 30mg/day and taking Oxy IR 20's and getting pretty ripped off them. My Opiate tolerance was Huge at that time, something like 600mg/day of Oxycodone. I used to have a daily dispense script from one doctor who no longer practices here, that would give me basically whatever I wanted. He gave me 10 OXY-IR 20's per day, and I would put all 10 of the big footballs in my mouth and once and swallow. Then about 15-20 minutes later, I am in such a good mood.

I currently take an SNRI (Effexor XR 150mg/day). I have done a lot of thinking lately, and I honestly am starting to think that Antidepressants don't really do anything, and if they do it would be a VERY subtle and mild relaxation, or mild stimulation depending on which AD you are taking and how your body responds to it.

Like the new doc I have is pretty cool, he actually does not agree with Antidepressants, because there is no actual 'link' to serotonin and Anxiety. Its more like people that get severe panic attacks or used to (like myself) and also now constant Generalized Anxiety - and over what? I have no idea. But its because we have low levels of GABA in the brain. I honestly don't think Effexor isdoing a damn thing at all, and I tried to get off by cutting my dosage in half, but then I was a mess and had to go back up to 150mg. So, NOW I'm FUCKED.

Because for starters I'm Physically Addicted to 4 drugs being: Opiates, Benzo's, Pregabalin, and Effexor XR, and big time psychologically adduced to Marijuana. It is so hard to maintain this habit month after month. And YES, I have been to rehabs, and detox centres. I would never goto a rehab facility or a detox facility ever again because they always taper you off Benzo's and Opiates at the same time, which is a BIG No-No. It just puts way too much strain and stress on your body, and a lot of these rehab facilities or detox centres have no idea what they are doing when they are doing a taper, or have never even heard of the Professor Heather Ashton.. Manual! I went through HELL, Complete and utter torture detoxing from benzo's and opiates at the same time...

Anyways. enough rambling and yacking for me, my apologies.

I just can't believe that I am finding this out now that SSRI's and SNRI's can fuck up your opiate high. cause i've been
using Opiates for approximately 8 years now, and I had never really noticed any interactions (Are you guys saying that I would 'feel' the opiates much more, and gather more Euphoria if I was off all SSRI's/SNRI's. Is there an actual source/link somewhere explaining this?

Thanks guys and gals.

 

[Sepher]

Are you guys saying that I would 'feel' the opiates much more, and gather more Euphoria if I was off all SSRI's/SNRI's. Is there an actual source/link somewhere explaining this?

It might not be that straightforward. I wonder if you might be trading increased analgesic effects against decreased euphoria, because while some SSRIs inhibit oxycodone conversion to more active metabolites, they would also tend to increase serotonin levels in combination with it, over and above what you'd expect from either the SSRI or the oxycodone alone. The combo is linked with increased risk of serotonin syndrome for instance.

I've found a PDF specifically covering opiate / SSRI and prescription med interactions that might be useful here.

 

[effie]

^ thank you for that link Sepher!

These sort of threads often get a bit more advanced than the ones we usually have in BDD, but I like 'em and I think it is good for people to learn about such things

Supeudol, I'm sorry you're having such a rough time right now. If you want some help/support/advice from people who have been there (or are geneally just very wise!) then pop over to TDS - link in my sig..