Yes. There are some that work. We don't like discussing novel structures here because then people want to sell them.
All of the NBOMe's [so far] display entactogenic effects; it's silly to expect 25B to be much better than the others based on structural analogy with some other molecule. None of them are very similar to their 2C analogs.
If you drop a single methyl group from the diethylamide on LSD, potency drops 20-fold. The apparent similarity of the chemical pictures used for didactic purposes has no relevance to activity.
Hah a couple things:
Better close down the 'dimemebfe' threads and a good portion of the posts in ADD because novel or at least mostly unknown chemicals are discussed, right?
Second, I mention entactogenic effects because I have spoken with someone lucky enough to try 25B-NBOMe and they specifically mentioned that they felt it to be less similar to the other 2c-x n-benzyl compounds and specifically that it was entactogenic. I made no assumptions or claims about 25B-NBOMe being 'better' as you mention. Nor did I claim that the NBOMe series closely parallels the 2c-x series.
And third this is nothing personal but I believe you have jumped on me about posting threads asking about unusual compounds before. Apologies if it was someone else and I'm mistaken, but the same argument was given before: structural similarity doesn't correlate with activity.
And the problem is that structure DOES partially correlate with binding affinity at the various types of 5-HT receptors! If looking at a molecule and saying 'Gee, all these compounds have substituents at the 4 position and are active so perhaps the 4 position is important for binding affinity' is wrong then Shulgin must have been such a fool to investigate how structure and activity correlate in the phenethylamine and amphetamine families, right?
I realize that's a gross oversimplification because other factors influence the PEA structure-activity relationship (look at the tweetios) but it should serve to get my point across.
Not to mention the same thing taking place with tryptamines as well albeit with a different relationship between structure and activity.
Please do not take this as a flame but really I would hope that people around here would be a bit less likely to make assumptions about the motivations and education behind my or anyone else's posts. How would you or anyone know whether or not I have any knowledge of chemistry?
It would take a very dull mind to have some knowledge about why psychedelics work and NOT ponder what might come of related compounds.
Back on topic:
I have enjoyed DOB myself. And DOI as well. I think that DOB specifically is interesting at lower doses. It produces a somewhat unique state of mind. I wouldn't take it again but I wouldn't take back having taken it before. Besides, I have put far worse into my body daily for years as a massive cocaine addict first and then a heroin junkie. I have a hunger for new, interesting psychedelic states and from the experiences of people that have indeed taken 25B-NBOMe I find myself interested.
