Not really. Similar to almost any other substances, the probability of experiencing an overdose whilst using barbiturates can be reduced to an essentially insignificant level if one uses the drug intelligently. An overdose is not something caused by a drug, per se, but rather the irresponsible, profligate, uncircumspect, impetuous, nescient, or generally reckless use of a drug.
Personally, I have used multifarious species of drug within the barbiturates family. My experience with them spans 5+ years. I have never overdosed even once from their use. I don't believe this is coincidental, and I attribute it to several preliminary procedures and preventive measures I punctiliously and customarily follow (to wit: educating myself on the specific drug's dose and other pharmacological features; using the drug in isolation or without any other CNS depressants in my system; having quick access to a sufficient quantity of an antidote for a barbiturate OD (in the improbable event that an OD still occurs) such as bemegride/methetharimide; minimizing drug redoses; etc).
Harm reduction does not begin and end at the decision to use a given drug. And just saying no to the use of a drug is never the only option to reduce or prevent one from sustaining or causing damage to oneself from the use of that drug.