I'm pretty disappointed that it is my generation that re-opened the door to using psychedelics in the 60's and 70's and is now the generation that has been staunchly defending the demonization and criminalization. At least with the work of MAPS and certain academics at Johns Hopkins and Harvard, not to mention organizations in the UK, there are a few sane representatives of my generation left that are out to change that, though.
I think that unfortunately legalizing for medicinal (therapeutic) uses will not lead to even decriminalizing for general use. I say 'unfortunately' because I believe in the ability to decide for oneself how one wants to change or affect consciousness. I don't want my direct experiences to be dictated by a medical model that says I must be suffering to take these substances. Many people use psychedelics as a way of re-setting themselves, of keeping themselves healthy the same way one might go hiking or do a cleansing fast or an intentional meditation. You do not have to have PTSD, anxiety or an addiction for these substances to be to your benefit.
As always the biggest group standing in the way of ending prohibition is parents. Parents are biologically programed to protect the safety of their children--as they should be. This can get out of balance and create fear rather than caution over everything from safety pads to weed. Rather than bashing parents for their fears, I would like to see our culture embrace a healthy context for the age old desire of humans to change their consciousness. Traditionally this was done as a way to transcend the small, egocentric human life we call reality and to remind us that there is something far greater than our own perceptions and judgments. If we ever want to end the prohibition against drugs we need to re-frame our conversation about why we take them. Anything from consumerism to commodifying the LSD (ayahuasca, weed, psilocybin, etc) experience can be made unhealthy and detrimental when no conscious thought goes into it. If parents had a way to feel comfortable talking to their kids about responsible drug use rather than thinking that to be good parents they have to espouse no drug use at all, we could start to see a different culture. We already do it (have the responsible use talk) with a very dangerous drug and the most commonly available to our kids: alcohol. So it shouldn't be that hard to imagine.