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Misc what receptors does nutmeg affect?

Lopez

Lopez

Bluelighter
Joined
Oct 21, 2010
Messages
416
it's been a day since i took nutmeg and i still have a good buzz going on. judging by the high i'm feeling i'd have to say it affects 5ht2a receptors and for sure the mACH receptors. does anyone know what else it effects?8)
 
I highly doubt it produces any 5HT2a agonism (such as drugs like LSD, mescaline and DMT do) but I could see it working on acetylcholine.

On the wikipedia pages for myristicin and elemecin (the 2 most active constituents) it says the former produces weak MAOI inhibition and both produce "anticholinergic-like" effects. I don't know if this phrasing indicates that they are not sure if the effects are caused by blocking acetylcholine or the observable reactions are just similar.
 
Last edited:
Nutmeg contains compounds that inhibit MAO. It also contains anticholinergic compounds.

edit - ^what cane said. The "anticholinergic-like" phrasing that they use comes from that study that they reference, where they're just observing clinical clinical effects. AFAIK actual anticholinergic activity from that compound hasn't been directly demonstrated.
 
Based on how the intoxication feels, I would have said MACh and/or GABAa, the above makes sense.

affects 5ht2a receptors
Click to expand...

Out of curiosity, what made you suggest this? Wouldn't have thought it would do shizz to the 5-HT system, beyond being a MAOI.
 
I actually used to love nutmeg. There seems to be a sweet spot when it comes to the dosing. If you take too much, you way too high and your body dries up. Too little and you feel nothing. But at doses where you are only mildly intoxicated, nutmeg gave me a mood lift, the most intense music euphoria I've ever had, and gave me that wondrous, excited-bout-life feeling I get from traditional hallucinogens.

I bet it's much more than just anti-cholinergic.
 
Interesting discussion, too bad I can not add anything from experience the GABA thing is really interesting. Can someone back this up with medical literature?
 
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