What makes Diazepam so balanced

[emkee_reinvented]

After having some experience's with prescription and non prescription Benzo's.

At detox I was given Diazepam, and that seems like one beast of a Benzo. I always talking bout how recreational Temazepam was. And Etizolam that seems to me as the ultimate grail.

Back to Diazepam, I got it 5 day's and was 'practically stoned for about 10 day's. Even had them half my dose after day one. But beside the extreme half live it does feel very warm/ cosy. Even 5 days after stopping, it was detectable in my blood even at day 13. To bad for that long duration and impairement. But other wise a great benzo imo. But it also seems very reinforcing as it targets anxiety, epilepsy, muscles and mind, and is verry sedating.

 

[Juniper Bruhmomentius]

Its a combination of many benzos, nordiazepam, oxazepam and temazepam. It a goat.

 

[negrogesic]

Seems to be a product of its smooth pharmacokinetics and fairly even action at the various subtypes of the benzodiazepine "receptor" (aka the little pocket on the GABAA receptor where these bind), particularly alpha 1, 2 and 3.



This means diazepam is effective as both a hypnotic, anxiolytic and muscle relaxant.

 

[Oldskipper]

Diazepam is the king of them all imo. Balanced is the proper word op, your bang on the money. They are every benzo rolled into one. People rave about xanax, for both therapeutic and recreational use. 5mg yellow diaz taken sublingually does exactly the same and keeps the anxiety for the whole day. Alprazolam however wears off in a few hours and pretty often the anxiety comes back threefold, so its necessary to redose.
As an aside, the only other benzo that comes close is librium, the rarely mentioned stepfather of diazepam.

 

[Serhat]

Diazepam (Valium) is often described as a "balanced" benzodiazepine because of its diverse pharmacological profile, which allows it to address multiple symptoms or conditions simultaneously. Here are several reasons why diazepam is considered "balanced":

1. Broad Spectrum of Effects: Diazepam has anxiolytic (anti-anxiety), anticonvulsant (anti-seizure), sedative, muscle relaxant, and amnestic (memory-impairing) properties. This wide range of effects makes it suitable for treating a variety of conditions.
2. Long Half-Life: Diazepam and its metabolites have a long half-life, which means it stays in the system for an extended period. This prolonged duration can be beneficial for ensuring that therapeutic effects persist over time, and it reduces the need for frequent dosing. It also helps with a smoother tapering process for patients looking to discontinue the medication.
3. Muscle Relaxant: Among benzodiazepines, diazepam is especially known for its muscle-relaxing properties. This makes it effective for conditions such as muscle spasms or conditions where muscle hyperactivity is a concern.
4. Active Metabolites: Diazepam is metabolized into several active metabolites, including desmethyldiazepam (also known as nordazepam), which also has benzodiazepine effects. This contributes to its long duration of action.
5. Efficacy in Alcohol Withdrawal: Due to its long half-life and broad spectrum of effects, diazepam is often used in the treatment of alcohol withdrawal, where it can manage symptoms ranging from anxiety and agitation to seizures.
6. Low Potency: Compared to other benzodiazepines like alprazolam (Xanax) or lorazepam (Ativan), diazepam is lower in potency on a dose-for-dose basis. This allows for more flexible dosing and titration.
7. Wide Therapeutic Window: Diazepam, like most benzodiazepines, has a wide therapeutic window, which means there's a significant difference between a therapeutic dose and a potentially toxic dose. This makes it relatively safe in terms of overdose risk, especially when taken alone (though any potential overdose or combination with other depressants like alcohol is dangerous).

Despite its "balanced" nature, it's essential to understand that diazepam, like all benzodiazepines, has a potential for dependence, tolerance, and withdrawal. Long-term or heavy use can lead to challenges in discontinuation and potential withdrawal symptoms. It's always crucial to use diazepam as prescribed and under the guidance of a medical professional.

 

[AlsoTapered]

I too believe that it's because it's 4 benzos in one due to metabolism. So we have benzos that are specifically prescribed for all of the conditions mentioned,

1)Diazepam
2)Nordiazepam
3)Temazepam
4)Oxazepam

I ended up using 24mg of diclazepam a day due to some severe long-term life events. I HAD to keep working so I broke rule 1, H had begun a reduction but bam- PSA.

So I ended up with a taper starting at 360mg diazepam/day (due to potency and duration of diclazazepam and because, well, it's also got 3 active metabolites but each of them is an order of magnitude stronger),

If you think THAT is crazy, I knew someone who was a big time hash dealer and one customer was happy to pay in blues (10mg diazepam tablets). So he ended up taking 100 of them a day. A GRAM of diazepam. But it's known that people without tolerance have survived intentional overdoses of multiple grams.

It took him two years BUT he managed it. It only took me 8 months. In fact, when it got down to 20mg I just stopped. So 1,4-benzodiazepines no longer have any notable effect on me.

1,5-benzodiazepines on the other hand still work PERFECTLY. I am VERY relieved about that.

Now I only take prescribed medication and smoke roll-ups. I'm obviously prone to drug abuse and self-destruction. My wife informs me that my cat, Sally, who died aged only 10 passed on her other 8 lives to me. I can believe that IF she could, Sally would indeed have done that for me. 5 years on and I still feel lost without her.