I live in South Africa so not sure if I could submit it there. It's a pure white powder, not crystal at all, not sure if that helps in any manner. I've ordered another larger batch that is arriving soon so I will see if I can find a good way to test it, maybe marquis? I will post pics of the test after they arrive for anyone who knows this stuff better than me
@
chris_p
I'm not a mod, but we do NOT allow just reagents results as proof, sorry.. It's an assumption and allowed with lab testing ... but not really allowed alone since the start of this discussion... I'm not trying to bash your lack of knowledge, only trying to educate with my deep understanding on chemistry to help others learn. Ive even have given sources locally in your area or how to find more below. They may or may not be free, but you can ask them the right questions we might want. Multiple reagents with something like a melting point test would probably be not used as proof. But will help with other assumptions auch as using a TLC plate, we may mark as an eh well you tried better then most, the data could help. Thank you for your submission .
Please at the very least please send to UVIC and getyourdrugstested for free. They will accept your donation by mail for free from any country they just don't advertise it. If you want to pay for QUALITY results with questions we can get feedback on, I suggest
https://www.kykeonanalytics.com/ for the lab results we NEED. and the quality of testing and response from our above greater then normal questions we can ask. Their prices are on par with energy control but have been more accurate with better equipment and responding to questions we need vs other lab services.
Now then for you. As an independent researcher . Your local or surrounding university maybe help. For example. ALOT of us use to use Tele Aviv mainly jere when it was less accessible in the USA.
Hebrew University NMR lab service
chem.ch.huji.ac.il
Choose from a wide range of experiments including some that are unique and not available anywhere else in the World.
Fast turnaround: Often the same day.
We can help with routine quality control, compound identification and assignment along with a wide variety of advanced experiments.
Ask our NMR team for advice. Tel.: 026585327, Email:
[email protected], Fax: 026585084,
Location: Room 3, Level 0, Philadelphia Building, Institute of Chemistry, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Jerusalem 9190401, Israel.
There is also closer to you. University of the Witwatersrand.
1 Jan Smuts Avenue,
Braamfontein 2000,
Johannesburg,
South Africa
The facility is pivotal to wide-ranging research programs and supports over a hundred users from the School of Chemistry and other departments within the University. In addition to this, NMR services are performed for several clients from industry and other academic institutions.
We provide services at different rates to:
Researchers and students within the University
Researchers from other academic institutions in South Africa
Scientists in Industry and the private sector
We are one of the best-equipped NMR labs in South Africa and we currently house a 300 MHz, 400 MHz and 500 MHz Bruker NMR Spectrometers.
www.wits.ac.za
NMR and Mass Spectrometry Service
High-resolution Nuclear Magnetic Resonance Service
NMR is available to students and researchers as well as industry through training, but a limited service is also run.
Training is conducted on the 300 and 400 MHz NMR instruments in the first place, but regular access to 600 MHz NMR requires a free-form application.
Occasional analyses are available through one of our trained operators to anyone for a fee.
This fee ranges from R50 an hour to R500 an hour depending on the complexity of analysis and sample.
Rhodes University
PO Box 94
Makhanda (Grahamstown) 6140
Eastern Cape, South Africa
+27 46 603 8111
[email protected]
Please test your product in a LAB, preferably multiple, then get back with results. We like to see HPLC/ HPLC-DAD, NMR, XDR (to check for polymorphs and hydrates), MALDI (molecular weight) and a polarimeter for Stereoisomers and chiralality as they molecules that have the same numbers and types of atoms, but differ in their three-dimensional relationships. They have equal atomic connections and orders of building blocks. If you are afraid or don't know what to ask. Just ask and we will help guide, you.
If you are worried about calling it MDMA. Call it by it's IUPAC, SMILES, or cas# to look more official. The formal (IUPAC) name is N-methyl-1-(3,4-methylenedioxyphenyl)propan-2-amine, but MDMA (CAS-42542-10-09) is commonly known as 3,4-methylenedioxymethamphetamine or methylenedioxy-methylamfetamine.
SMILES denotes a molecular structure as a graph that is essentially the two-dimensional valence-oriented picture chemists draw to describe a molecule. In chemistry, "SMILES" stands for "Simplified Molecular-Input Line Entry System," which is a standardized way to represent the structure of a molecule using a simple string of characters, allowing computers to easily read and manipulate chemical structures; essentially, it's a line notation system for describing chemical compounds using a short, computer-readable format.
Functionality:
SMILES allows users to input a molecule's structure as a text string, which can then be used by computer programs to generate 2D or 3D molecular models, perform calculations, or search chemical databases.
Structure representation:
The string consists of symbols representing atoms, bonds, and ring closures, with specific rules governing how these symbols are combined to accurately depict a molecule's connectivity.
It's smiles for MDMA is.
CC(CC1=CC2=C(C=C1)OCO2)NC
You can even ask how this sample will vary from what was stated and why.
Enantiomers testing, and other more official like DIY experiments currently partially allowed as experimental only.. such as TLC spot plate or melting point.
This type of stereoisomer is the essential mirror-image, non-superimposable type of stereoisomer introduced in the beginning of the article. Figure 3 provides a perfect example; note that the gray plane in the middle demotes the mirror plane.
GC/MS is ok but not thought of around kindly, in the analytic testing community here by a few people.
Our mission is to advance the health and wellbeing of people who use psychoactive drugs. The main way we do this is through hosting, managing and maintaining supportive digital communities.
Geometric isomers have the same empirical formula or molecular formula and also the same structural formula, but have a different relative arrangement of the substituent groups. For example, the two geometric isomers of 1,2-dichloroethene (Figure 1.7.1
.31) have the molecular formula of C2H2Cl2, and the same structural formula of Cl(H)C=C(H)Cl, but the relative position of the two chlorine atoms can either be the same side of the C=C double bond (i.e., cis, see Figure 1.7.1 .31a) or on opposite sides of the C=C double bond (i.e., trans, see Figure 1.7.1
.31b). The use of cis and trans is not limited to organic compounds such as olefins, but can also be used in metal complexes,
A chiral molecule is non-superimposable with its mirror image, and has a "handedness" (think of shoes, which specifically go with a right or left foot) it D METH vs DL meth vs L meth. An achiral molecule is superimposable with its mirror image and do not have "handedness" (think of a baseball bat, which can be used with either hand)..
Now this is one test DIY YOU can experiment with. But is not official and in our testing phase.
Normally a polarimeter is a very important tool in my opinion. Unfortunately, but not many have the money to buy one, I will explain a DIY polarimeter to you. Isn't as accurate as a store-bought one, but at least you can see if it's chirally enriched. With a few modifications. Can it be made much more precise.
You will need :
-A cuvette
- Polarized foil
- Your smartphone (LCD, OLED display)
-Look at the polarized film on the smartphone display to see how it behaves. And when they turn it. Make a small continuous line over the foil and the smartphone. Preferably when they can't see anything through the foil and it's black.
- fill the cuvette with distilled H2O, mark the ml level on the cuvette.
- Now turn on your smartphone and make sure that the screen illumination stays on.
- Now place the cuvette on the smartphone screen
- now hold the foil over the cuvette, preferably on the old lines where you could no longer see through the foil at the beginning. Normally, it should be the same as before.
- Now you are producing a well-known h2o solution with your product. And fill your cuvette with it up to the ml mark on your cuvette
-Now put it back on your smartphone, and hold the film over it, ideally you should when you put the film on the
Set aligned strokes. If you can see something through the foil, then you know it's chirally enriched. If it is still black, then there is still a racemat.
As I said, the method is not the most accurate, but at least somewhat
These 2 sheets of polarizing film were $5 on Amazon. I could easily cutnthem inton32-1" squares, which is plenty big enoughntomcover a test tube.. A tip, if its optically active( you see light at the start) If you turn it clockwise and it goes black, its dextro, and if the black spot is counterclockwise from your start it's levo. You can even estimate the enantiomeric excess by how far it turned, with a little practice. As such the mol weight, polymorphs impurities dont like to be picked up on GC/MS let alone reagents is why we do not accept reagent results alone.
Living in South Africa is no excuse now, and understanding why we don't allow reagent results by then selfs. I'm not trying to flame, belittle or anything like that. This forum and discussion has evolved. And in order to answer your and everyone else's questions reagents and even most basic labs WILL NOT HELP US. And you need to go seek others I have mentioned for a baseline at least for free and more advanced paid to really progress.
Some European ones allow delivery by mail but you will need a mailbox in the county that does the testing. If you did that AFTER that confirmation with reagents will be tolerated. Saying you live in South Africa is now NO EXCUSE. The path for a molecule, therefore, from early-phase API and drug product to a commercial product, is an iterative one. It involves increased levels of understanding around the synthesis, potential impurities, isomers, crystalline forms, and physical properties—all of which need to be controlled and understood to the fullest, as they can have an effect the safety and pharmacology of the drug.
As stated earlier
I'm familiar have tested Multiple batches with the purple color all passed as MDMA via multiple labs. It is manily caused by impurities in the synethsis they leave after recrystallization. You have have junk sit but still forms big rocks of MDMA and junk and basic labs can't decern. And YES, I've personally extracted, purple junk out of white MDMA. And if you let junk sit in a jar or 55 gallon drum and let the solvent evap slowly it does test as MDMA but it's bad impurities mostly. But someone I know personally doing bulk has encountered a dyed product that was purple. It was starting when the purple hype started, but not as common as one will think.
Also just because it's clear doesn't mean it is good. Ive turned the white MDMA, removed purple shit and turned white into CLEAR MDMA that straight up looks like meth shards 3-5 inches long. The product was in fact MDMA. Still tested as MDMA. But multiple people said the original white batch was better then my recrystallization batch. I assume because my area has extreme humidity and made a hydrate or dimmer when chemically bonding.
A semi approved diy home test that might be ok around here would be, multiple reagents, a melting point test, a TLC spot plate, a DIY polarimeter and column chromatography.
Usually you run a tlc before a column to find the best column conditions/solvent(s), then you tlc the column fractions afterward to check that everything separated / which fractions have product. A lot of the time before running your column it’s important to know how your unknown behaves in different solvent systems. Running TLC standards beforehand can help with this. It clearly shows you which solvent system has a high degree of separation and which will elute one component better than the other. In other words it guides you to picking a good mobile phase for use in your column.
If a mod or a staff member has a different take, then feel free to let me know and I'm willing to modify or clarify. We are all hear to learn about this on a deeper level with most of us having no understanding to good understanding to degree level understanding.
The path for a molecule, therefore, from early-phase API and drug product to a commercial product, is an iterative one. It involves increased levels of understanding around the synthesis, potential impurities, isomers, crystalline forms, and physical properties—all of which need to be controlled and understood to the fullest, as they can have an effect the safety and pharmacology of the drug and reagents aren't going to cut it man.
Do they serve a purpose. Yes, but for our observations reagents alone is a no
