Interestingly, the polydrug synergy is reduced when meh-MDMA is administered first.
Yeah but the polydrug synergy is reduced when
MDMA is administered first. What people call "MehDMA", is what I just think of as shitty ecstasy, and that could be for any of a number of very plausible reasons, all with outcomes too similar to delineate from one another via bioassay. MDMA will trigger the massive release of pre-synaptic serotonin it's known for, in which it primarily acts as a serotonin releasing agent, but it
also acts as a serotonin reuptake inhibitor, blocking the serotonin transporter eventually, essentially inhibiting its own action after the initial effects. This, among other reasons, is why it's best to re-dose only once, if at all, early into the experience in case you
eased into it… However, this also happens to inhibit other serotonergic drugs, like psychedelics.
Meaning to say: it's quite arbitrary to attempt to establish some would-be threshold of MDM-meh
*. It will wind up in circular logic, impossible-to-prove subjective claims, and endless "debate" or "discussion" or whatever on this topic, because, by design, the original post held a loaded question that I honestly think was the result of unconscious confirmation bias. It's hella easy to do, and I'm also willing to admit that I may be under the effects of my own confirmation biases. It's virtually impossible to know now as the relevant samples to test for previous claims of sublime MDMA experiences are locked away in the past.
* ☞ this is my version of the term, which I feel rolls off the tongue more easily; saying "MDMA" starts with a "emm" sound, not a "meh" sound; meanwhile it fits in more nicely with the terminating phonetic "m-ay"
This is explicitly mentioned in the meh-MDMA
effects profile.
This "effects profile" post from years ago is certainly well-written, educated grammar and syntax, and it cites other works, too. So it comes across authoritative, official, and rigorously studied, proofed and presented or whatever, but let's keep it real, here. You will not find MDM-meh or any version of same in, say, The Merck Manual or any other respected publishing. So it doesn't matter what anecdotal verbiage was used in the original thread post here; nothing about it is "official" or well established in any scientific or medical community as far as I know, but as always I'm open to being proven wrong by evidence…