The RLS is the worst thing to me. As a kid, me (and my brother, and my mom) would get RLS... but there was no medical term for it, we called it "crazy legs". Our family doctor rolled his eyes at us when my mom tried to talk to him about it. It was so bad, when I was really young I walked around with my toes curled in my shoes, clenching my legs as hard as I could, a lot of the time. Got in trouble for putting my legs in the aisles at school. Couldn't sleep sometimes. Fast forward to opiates.... ahh, no more RLS. Then fast forward to withdrawals... oh GOD THE WORST RLS. Full-body restlessness, not just legs, it crept into the arms. People who haven't experienced RLS (like my sister) think it's weird, like, just don't move, it's simple. It's not simple, it's fucking hell. The worst feeling, like you're going to crawl out of your skin. My history with it is probably why RLS is the worst symptom for me. When I used to be on opiates, I'd make it to like day 5 and then always cave because 5 days of no sleep plus terrible anxiety and depression is a bitch. I can remember laying in bed thrashing all night and finally starting to punch my legs over and over and hard as I possibly could, for like 60 seconds straight, so they'd feel numb and heavy for a couple of minutes at most.... huge bruising the next day, but so worth it.
Weirdly, since I quit opiates 6 years ago, I never get RLS anymore. My brother and mom still do and have never done opiates.