Alcohol --> When I was 18 (and a total alcoholic) I had 15 shots of Bacardi 151, and 4 Coronas. Needless to say, I threw up in my sleep after passing out, and woke up the next day sicker than hell in a pile of vomit. I didn't feel normal for 3 days.
Weed --> Three friends of mine and myself partook in smoking a quarter pound of kind bud in about 36 hours while on an ecstacy binge.
Ecstacy --> Only 4, but they were extremely weak pills. Most fucked up I've been was off of 3 - I was cracked out for the whole next day.
OC's, Perc's, and Valiums --> I don't know the exact number, but I would have to say at the absolute minimum 5 OC's, 5 BIG percs (10/650'z I believe), and 5 valiums, although it was probably closer to 6 or 7 of each. This was in a matter of 4 or 5 hours. I woke up about 36 hours later, kinda sick and groggy, with the worst body-itch imaginable.
This is why I no longer abuse drugs.
-ShaDDoW