What is happening during pregabalin withdrawal and is there anything to reduce it?

[swilow]

Question is as thread title. What is happening during pregabalin withdrawal? It feels quite adrenergic to me; at least, the panic symptoms are. But I wonder why it is so depressing, so dysphoric. I would have thought that various monoamines ramping up may lead to a sense of anti-depression. Does it not inhibit the release of things like serotonin and noradrenaline?

I'm wondering why magnesium is thought to attenuate it somewhat. And is there anything else to be done?

I posted here as I was hoping for something quite technical. Thanks in advance.

edit: I am taking mirtazepine also (and multiple other meds, mainly anticonvulsants). Would mirtazepine potentially make the subjective experience worse? Given that is acts to indirectly increase various monoamines.

Its fucking kicking my ass atm. Though I do not feel totally bad, I feel extremely stimulated with incredibly sensitive skin, deep pain/coldness in bones, but the actual thing I intially took it for- sciatica- hasn't really reemerged.

Would buprenorphine help? I have little choice but to take it, so I hope so!

 

[Cotcha Yankinov]

In theory pregablin withdrawal should involve rebound release of whatever transmitters pregablin was originally inhibiting.

Pregablin tends to inhibit glutamate and substance P, both involved in neuropathic pain. Glutamate can stimulate a receptor called NMDA, upregulation of which is involved in neuropathic pain. Magnesium blocks the NMDA receptor naturally, hence the talk of magnesium. However it may not be horribly potent at blocking it when taking it supplementally.