Misc What is "Conditioned Place Preference"?

[DeathIndustrial88]

I dunno what sub to post this in, but I'm curious if anyone could explain to me what "Conditioned Place Preference" means?

For example in this article - Says tramadol causes CPP and Tapentadol does not. Only thing I've gathered so far is that it has something to do with the reward system.
Would this mean that tramadol would cause a stronger psychological dependence than tapentadol? But what is meant by "Place Preference"? Like people prefer to do their drug in a certain space/place or something? lol Or are they just referring to the behavior of the rats?

Tramadol and Tapentadol Induce Conditioned Place Preference with a Differential Impact on Rewarding Memory and Incubation of Craving

Tramadol and tapentadol, synthetic opioids commonly prescribed for moderate-to-severe pain, have a unique pharmacology that optimizes their analgesia and safety. However, they are not devoid of risks, presenting addictive, abuse, and dependence potential. While tramadol-reinforcing properties...

www.mdpi.com

Also I'm not sure why every website acts like tapentadol is "stronger/more pain relieving" than tramadol, especially when tapentadol is only a partial agonist & tramadol works through an active full agonist metabolite. Tapentadol has higher intrinsic activity than buprenorphine at least though.

I see this a lot though, people & even actual medical websites pretend like just because an opioid is "more potent", then it must be "stronger/better in effects". When that's not really the case. An opioid can be incredibly potent & have shitty effects or it can have a really weak potency but still provide decent effects.

Intrinsic activity & sub-receptor affinities is what actually makes an opioid worthwhile.

Are there any ways to make tapentadol a better drug? If I try to dose too high, I get weird ass NRI side effects like brain zaps/glitching, mild hallucinations, etc..

Google says not to take more than 600-700mg of tapentadol a day, but I don't see how anyone could even handle those numbers considering 300mg gives me brain glitches. I refuse to go above 300mg a day because the brain glitches feel like I'm zipping in & out of consciousness incredibly fast, like a split second. This doesn't seem to be a problem at lower doses though, but some times the lower doses don't present strong enough opioid effects.

​

 

[tryptakid]

I dunno what sub to post this in, but I'm curious if anyone could explain to me what "Conditioned Place Preference" means?

For example in this article - Says tramadol causes CPP and Tapentadol does not. Only thing I've gathered so far is that it has something to do with the reward system.
Would this mean that tramadol would cause a stronger psychological dependence than tapentadol? But what is meant by "Place Preference"? Like people prefer to do their drug in a certain space/place or something? lol Or are they just referring to the behavior of the rats?

Tramadol and Tapentadol Induce Conditioned Place Preference with a Differential Impact on Rewarding Memory and Incubation of Craving

Tramadol and tapentadol, synthetic opioids commonly prescribed for moderate-to-severe pain, have a unique pharmacology that optimizes their analgesia and safety. However, they are not devoid of risks, presenting addictive, abuse, and dependence potential. While tramadol-reinforcing properties...

www.mdpi.com

Also I'm not sure why every website acts like tapentadol is "stronger/more pain relieving" than tramadol, especially when tapentadol is only a partial agonist & tramadol works through an active full agonist metabolite. Tapentadol has higher intrinsic activity than buprenorphine at least though.

I see this a lot though, people & even actual medical websites pretend like just because an opioid is "more potent", then it must be "stronger/better in effects". When that's not really the case. An opioid can be incredibly potent & have shitty effects or it can have a really weak potency but still provide decent effects.

Intrinsic activity & sub-receptor affinities is what actually makes an opioid worthwhile.

Are there any ways to make tapentadol a better drug? If I try to dose too high, I get weird ass NRI side effects like brain zaps/glitching, mild hallucinations, etc..

Google says not to take more than 600-700mg of tapentadol a day, but I don't see how anyone could even handle those numbers considering 300mg gives me brain glitches. I refuse to go above 300mg a day because the brain glitches feel like I'm zipping in & out of consciousness incredibly fast, like a split second. This doesn't seem to be a problem at lower doses though, but some times the lower doses don't present strong enough opioid effects.

​

Conditioned place preference is the experience of preferring to be in a physical location or context where a rewarding substance has been used.

If you use dextroamphetamine (known as being something that creates conditioned place preference) when you go to work, and while you're working you spend a lot of time in your office at your desk - you will become conditioned to prefer being in that place over locations where you aren't taking amphetamine.

During CoVID, there were many people who began taking amphetamine to help focus while working from home. There is very likely a pharmacological effect that has occured where people became conditioned to preferring to work from home over going into the office, as remote work became conditioned.

This phenomena can also be observed even when someone is not on a substance - so you will still see a conditioned place preference effect if you are abstinent from a substance but have the choice of being a previously conditioned environment. So if you stop taking amphetamine, you'll still prefer to be in your office, or in your remote workspace, over non-conditioned environments.

This is likely linked to dopaminergic activity which has heightened activity under the influence of certain exogenous substances (amphetamine being a classic example, but also opioids as you've noted). That increased firing is essentially signaling to your brain "yes, be here, do this thing, stay in this context) and the more you reinforce that through repeated use in specific environments, the stronger that conditioned response will be.

 

[DeathIndustrial88]

Conditioned place preference is the experience of preferring to be in a physical location or context where a rewarding substance has been used.

If you use dextroamphetamine (known as being something that creates conditioned place preference) when you go to work, and while you're working you spend a lot of time in your office at your desk - you will become conditioned to prefer being in that place over locations where you aren't taking amphetamine.

During CoVID, there were many people who began taking amphetamine to help focus while working from home. There is very likely a pharmacological effect that has occured where people became conditioned to preferring to work from home over going into the office, as remote work became conditioned.

This phenomena can also be observed even when someone is not on a substance - so you will still see a conditioned place preference effect if you are abstinent from a substance but have the choice of being a previously conditioned environment. So if you stop taking amphetamine, you'll still prefer to be in your office, or in your remote workspace, over non-conditioned environments.

This is likely linked to dopaminergic activity which has heightened activity under the influence of certain exogenous substances (amphetamine being a classic example, but also opioids as you've noted). That increased firing is essentially signaling to your brain "yes, be here, do this thing, stay in this context) and the more you reinforce that through repeated use in specific environments, the stronger that conditioned response will be.

Thank you so much!
You explained this very well in a way I could easily understand, so I appreciate that.

I guess I was sort of on track with what I thought it meant.

Maybe this would explain why I have nostalgic memories for being in places/environments that remind me of when I used tramadol & heroin. But I rarely find myself getting nostalgic for times when I used say hydrocodone, buprenorphine or tapentadol.

It's interesting, because there's also a thing called "environmental tolerance", where you'll get more tolerance to a drug while doing it in the same place but if you go somewhere else & do it, the effects might be stronger.

Again, I appreciate that! Makes sense now, especially when combined with my experiences when it comes to tapentadol VS tramadol VS any other opioid I've ever tried.

 

[tryptakid]

Thank you so much!
You explained this very well in a way I could easily understand, so I appreciate that.

I guess I was sort of on track with what I thought it meant.

Maybe this would explain why I have nostalgic memories for being in places/environments that remind me of when I used tramadol & heroin. But I rarely find myself getting nostalgic for times when I used say hydrocodone, buprenorphine or tapentadol.

It's interesting, because there's also a thing called "environmental tolerance", where you'll get more tolerance to a drug while doing it in the same place but if you go somewhere else & do it, the effects might be stronger.

Again, I appreciate that! Makes sense now, especially when combined with my experiences when it comes to tapentadol VS tramadol VS any other opioid I've ever tried.

Absolutely!

SItuational (environmental) tolerance is a seperate but likely related experience where environments that are tied in the brain to previous use result in the brain 'expecting' to receive a pharmacological stimulus, and preparing accordingly. If you frequently drink alcohol at home in your living room, you may find that 1 or 2 drinks has little effect, while if you have that same amount in an unfamiliar context, you have more of a noticeable effect. I honestly think that this lead to large number of alcohol related blackouts that got flagged as "drink spiking" in the early post-pandemic period were linked to this. People had become accustomed to drinking at home, and upon starting to go out and drink at bars/clubs, they were walloped by how intoxicated they go when they were used to handling a similar amount of alcohol at home. There's even examples of people overdosing from drugs that they are tolerant to, simply because they were using in a new place.

 

[ĐmantuNJofra]

Conditioned place preference is the experience of preferring to be in a physical location or context where a rewarding substance has been used.

If you use dextroamphetamine (known as being something that creates conditioned place preference) when you go to work, and while you're working you spend a lot of time in your office at your desk - you will become conditioned to prefer being in that place over locations where you aren't taking amphetamine.

During CoVID, there were many people who began taking amphetamine to help focus while working from home. There is very likely a pharmacological effect that has occured where people became conditioned to preferring to work from home over going into the office, as remote work became conditioned.

This phenomena can also be observed even when someone is not on a substance - so you will still see a conditioned place preference effect if you are abstinent from a substance but have the choice of being a previously conditioned environment. So if you stop taking amphetamine, you'll still prefer to be in your office, or in your remote workspace, over non-conditioned environments.

This is likely linked to dopaminergic activity which has heightened activity under the influence of certain exogenous substances (amphetamine being a classic example, but also opioids as you've noted). That increased firing is essentially signaling to your brain "yes, be here, do this thing, stay in this context) and the more you reinforce that through repeated use in specific environments, the stronger that conditioned response will be.

yes you nailed it so I tried to find and found this thread but didnt even heard about that term meaning it is obvious in translation but context you nailed it

Phenibut-lsd-cannabis-ketamine are my choice of conditioned OCD type best movies and TV shows as mixing music house and listening to some old rock like UFO, Black Sabbath, Scorpions, Panters when on smphetsmines and yes one can do a great job on them like on low dose pregabalin I test it for like months now sometimes it is frickin hard as clonazepam withdrawal gets in the way but Ketamine if I have it takes care of that, while after waking up MPH in Concerta prescribed both gets the job done like writing for others and video edit