What exactly happens to the brain when you crave Drug?

[shahab6]

What exactly happens to the brain when you crave Drug? What causes the brain to start craving drug?
When I first started doing drug, I never crave it, or if I did it was very light. But one day, I started getting crazy intense craving
for opiates. Like craving so bad, that my head would hurt. And enough to cause me to go crazy. I ended up going on suboxone,
and the craving went away. And once I got off, I didn't have craving anymore. So what exactly causes this?

 

[Shady's Fox]

I dunno exactly but it's not linked with your reward system. It's the crave for better, for exploration or in one word the need for primal.

Read this

The clinical significance of drug craving

Although drug craving has received considerable research attention over the past several decades, to date there has been no systematic review of the general clinical significance of craving. This paper presents an overview of measurement issues of particular ...

www.ncbi.nlm.nih.gov

 

[shahab6]

I dunno exactly but it's not linked with your reward system. It's the crave for better, for exploration or in one word the need for primal.

Read this

The clinical significance of drug craving

Although drug craving has received considerable research attention over the past several decades, to date there has been no systematic review of the general clinical significance of craving. This paper presents an overview of measurement issues of particular ...

www.ncbi.nlm.nih.gov

Thank you, I tried reading it, but it was a bit too complicated for me.

 

[dopamimetic]

Any research yet in antagonizing DeltsFosB? Sounds like this would be a gold mine.

 

[nznity]

I dont want more drugs..... I just want somebody that i can Trust, care about AND love with all my heart. AND for it to be reciprocate....Is that too much to ask? I Wanna wake up next to that person AND just Stare at her, hug her AND feel awesome. Fuck synth drugs.
LOVE Is errrthing.

 

[dopamimetic]

Maybe I never experienced true love yet, seems this is something pretty rare.. But drugs were always more honest to me. They fuck my brain but I know what to expect..

 

[Jabberwocky]

It can be a vicious circle taking drugs because you have no love given that drugs can make you pretty unlovable. This is one of my basic errors in life.

 

[dopamimetic]

It can be a vicious circle taking drugs because you have no love given that drugs can make you pretty unlovable. This is one of my basic errors in life.

That's very true but it can and does prevent things like suicide or in some times violence.. Bad or worse is often the only choice left.

@ibtisam midlet very interesting. Can these markers even be influenced directly?

The dominant negative mutant variant of JunD, known as ΔJunD or Delta JunD, is a potent antagonist of the ΔFosB transcript, as well as other forms of AP-1-mediated transcriptional activity.[7][8][9] In the nucleus accumbens, ΔJunD directly opposes many of the neurological changes that occur in addiction (i.e., those induced by ΔFosB).[8][9] ΔFosB inhibitors (drugs that oppose its action) may be an effective treatment for addiction and addictive disorders.[10]. Being an unnatural genetic variant, deltaJunD has not been observed in humans.

So this is a theoretical thing?