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Opioids What drugs lose potency after being dissolved in water?

A

avogradoheisenberg

Greenlighter
Joined
Oct 3, 2012
Messages
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I was wondering if someone were to dissolve a certain medication in water (room temperature), and then put it away in a closet or cabinet, would it damage the drug? Oxycodone is the drug I would want this discussion to revolve around, but any information on any other drugs would be nice too. Let's say we were to crush a pill that contains oxycodone and pour into a glass of water at room temperature and let it dissolve. What happens to the potency after 6 hours? 12 hours? 24 hours? A week? Month? Year? I'm speculating that after a week of being dissolved in water and stored in a non-harsh environment, no more than 10% of the drug should be lost. In other words, after dissolving a 20mg tablet in container filled with water and letting sit there for a week, it should feel like 18mgs at the very least after consumption. What do you guys think? Any information would be really appreciated. Thank you :)
 
If it was airtight and kept at a reasonably cool temperature around 2.C then i doubt much potency would be lost after a week maybe even non or negligible.

Being out of sunlight is very important aswell so closet maybe not be dark enough.
 
I honestly don't know, you could use a different solution like something with a preservative. What I mean is they keep oxycodone in a solution for IV use in a hospital environment so Im guessing that that oxycodone solution for IV degrades very slowly(it probably doesn't expire for years. So if was wanting to do this i would google oxycodone IV solution and find out what's in the solution. I bet benzyl alcohol or something would be a good preservative.
 
Yep and as the above poster said keep it out of the sunlight for sure: try googling oxycodone degradation or something.
 
Thanks guys, mold didn't cross my mind lol. It looks like you guys are answering in a way that makes it safe for IV use. I'm not thinking about IV as route of administration but rather safe oral use. Would too much mold/bacteria accumulate after a week? Let's assume that the dissolved drug is being kept inside a water bottle and that the water used initially was from the water bottle itself. Would it be unhealthy to drink it after a week? A month? How long for it to be unhealthy to drink? Thanks again
 
I'm no chemist, but wouldn't there be four ways in which it a substance in water could degrade?:
1) It binding with water molecules (or any other substances in the water)
2) The drug braking down due to external forces (heat, ultraviolet radiation, etc)
3) Microorganisms metabolising the drug
4) The drug being unstable and breaking down naturally (half life and all that)

I guess you could minimise most of these by using pure water and storing it in a dark and cold environment which is hostile to microorganisms.

Either way, from this article it seems that you have to keep it stored in a light-proof container.
 
Hey King-Anubis, thanks for your reply. Those four ways you've mentioned are things to worry about. I wish someone could give me some calculations though. What do you think is best. Keeping it in a refrigerator or storing it in a closet where absence of light is complete. If it were in the refrigerator it would have exposure to light at times but in the closet it would be at room temperature, not cold.
 
According to this study, it seems that over 28 days you could expect, at worse, to lose 3.9% of the drug (Concentration?) Might be best to wait for someone with more experience in pharmacology or chemistry to interpret the results, but if I we're you I'd plan to lose 5% every month in a glass container protected from light. Although it seems the cold is more important (Highest loss in substance concentration was with the substance protected from light, mixed with NaCl or Water...)
 
Thank you! That's a nice article. Anything below 10% would be great. Especially in a month time frame. I was planning on just letting it sit there for 2-3 weeks. Thanks :)
 
^ it will oxydize and the solution will turn brown-red. As a way to remember it, just how an iron bar would rust when put into water, the heroin solution also rusts, gives red-brown color.

Same with codeine and ascorbic acid (vitamin C) solutions. The solutions will brown, vitamin C turns into dehydroascorbic acid. What browns these solutions are:

- light
- heat
- air exposure
 
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