I'm going to move this from Basic Drug Discussion to Drug Culture. Hopefully that is a better place for it?
I assume you mean what drug increases self-confidence and reduces social anxiety etc, as opposed to what drug is "egotistical". A drug can't be egotistical, egotistical means being self-centered or having an inflated idea of one's own importance. And you wouldn't really want a drug to make you egotistical either. However, I don't know if this question is really appropriate for BDD, as it is not a basic drug info or harm reduction question, it's more a matter of opinion. Everyone is going to have different effects from different drugs and a different opinion of which most increases one's self-confidence. For example, some people find cannabis to make them more relaxed, comfortable with themselves and talkative, whereas some people find it to do the opposite and make them insecure and paranoid. There are also some potential problems like a drug might make you feel more self-confident but not necessarily in a good way, like it may totally decrease your inhibitions to the point of making you regret how you behaved while on it. Or a drug might be "good" for making you feel self-confident but have other unwanted side-effects, or only do so in the right dose, etc. So it seems like a question that will encourage endless speculation and not something that there is a simple answer to.