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What could biochemically be wrong with me?

interplanetary

interplanetary

Greenlighter
Joined
Aug 29, 2010
Messages
22
Location
Xibalba
Salutations Brothers in a Shared Craft,

I consider myself to be somewhat of a psychonaut. I have a plethora of experience with N,n DMT, 5-MeO DMT, 4-acO-DMT, LSD, psilocybin, and the list could go on, but if it's all the same to you, I'd like to just get to the point here.

I've noticed that with the 2C-family I simply do not respond in the way that anyone posts about in TRs and the like. Out of my trails with 2C-D, 2C-I, and even 2C-T-2, I have not gotten any psychedelic feedback -- no OEVs or even CEVs. The lack of feedback doesn't stop there, even on 2C-D, I receive little to no introspection and I am having a hard time believing that it is at all possible, from my experiences, that this could have even a nootropic value.

So my question is -- while not in the same context as the title -- has anyone experienced this. If not or even if so, what seems to running reasoning behind this?

All trails were done in a fasted state and moderate application of synthetic cannabinoid use to at times, none at all. Doses were taken orally (2C-D averaging 52mg, 2C-T-2 averaging 22mg.)

Namaste'
Sigma D.
 
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orangelicker said:
Are you sure that these chemicals are, in fact, these chemicals?
Click to expand...
That is certainly not the case. I know a 2C when I see one and this was purchased from a highly reputable source. That is normally my first question posed, trust me. This is something specific with my response to phens I'm guessing.

For example, I am on an oral dose of 2C-T-2 of 22mg and at +02:39 and feel hardly any feedback and certainly none psychedelic. I am disturbed by this. This, of all phens I tried, was the one I steered away from doing due to the TRs about a horrendous bodyload and guaranteed nausea.

My response: body load is very doable and nausea.


...


-_-
 
^^ SSRIs increase phen effects... at least with 2C-T-2

OP I think you just need to raise your dose... Do you do any stims? Eat a lot of chocolate? Both of those things will raise your PEA tolerance...

And I didn't trip until 32mg of 2C-T-2... and 2C-D was 100mg...
 
So you have the 'normal' response to tryptamines, just not to PEA's (2C's)? I can't really see any reason why this should be so, as both classes of drugs act by agonism of 5-HT2A receptors... It could, possibly, have something to do with differences in metabolism between the two types of drugs, I don't know much about that.

What sort of doses of tryptamines are you used to? If you're used to taking huge doses of those I expect low-medium doses of PEA would be somewhat underwhelming. Though 22mg of 2C-T2 should be well above threshold... Tolerance? Anti-psychotics!?

Kat, do you mean you didn't trip properly until 32mg of 2C-T2? Did you get threshold effects well below that?
 
Do the PEA's and trypamines bind the same sites on each receptor? For example if they bind different pockets on the 5-ht2a receptor perhaps you have a point mutation in the binding site for 2c's.

Another question if you take a 2c and get no effect does it still give you tolerance to trypamines?
 
have other people tripped off your batches of these chemicals?

degradation is a possibility
 
You aren't taking these phens like a big glass of orange or grapefruit juice are you? Or within 3 hours of a meal? It's a known pharmacological fact, warned for with a sticker on bottles of amphetamines, that an acidic stomach environment greatly impedes the absorption of phenethylamines, as well as speeding their elimination. A recent meal greatly increases acidity of the stomach for obvious reasons. As does recent consumption of acidic juices or vitamin C supplements. I have experienced the effect myself before I found out about this interaction issue. Bottles of Adderall as well as dexedrine from a pharmacy now come with a sticker saying to avoid these things for this reason, and amphetamines as well as 2C's are of course all phenethylamines that are subject to this phenomenon.

If no recent meals or no large amount of juices or vitamin C, maybe you just have an unusually acidic stomach and/or intestine, which may not be out of the question. Have you ever suffered from periods of hearburn or acid reflux? These can both be signs of continuously elevated and abnormal levels of acid in the stomach and I am pretty sure this could well affect absorption of phenethylamine even worse than a 16oz glass of GFJ.

You can try taking a teaspoon of baking soda, or like 10 big chewable Tums on an empty stomach exactly 10-15 minutes before taking the the 2C and see if that helps. Seems unlikely that every single one of your past trials had zero effect on you for this reason, you would think that one of those trials would have hit at an advantageous stomach time, but who knows.

I honestly suspect either issues with the source, dillution to stretch their supply (both are not totally unheard of even with previously trusted sources) or improper storge leading to degradation.

I was at one point for a few months on antidepressants, and they blocked 95% of the effects of EVERY psychedelic I tried... LSD, Shrooms, MDMA, 2CI all had almost no effect when the same batch worked fine before, and 3 weeks after stopping them. Went from Prozac to a few others when I didnt like the side effects, and settled on Wellbutrin (which has a weaker effect on serotinin, but still a significant one, and they ALL seemed to block tripping for me.

If you still respond to Tryptamines though, I would say a stomach acidity thing, or just bunk or highly cut chemicals, for unknown reasons. Before racking your brain for exotic biochemical theories that make your biology highly special or unique, you really ought to apply Occam's Razor, and start with getting the necessary test kit to check your chems. OR, the best possible test might be to give them to at least 2 other people, being sure to go over to above caveats with them, since a test kit would just show the presence of SOME of the tested-for chem, but wold not let you tell the difference between 99% strength, and a highly cut 20% strength.

Also, I am curious as to exactly how you "know a 2C when see one". That's a pretty funny comment, and not even close to being possibly correct.... you'd have to have Mass Spectrometers inside your eyeballs for this to be true. 2Cs look precisely like any of a thousand other crystalline white powders that will have absolutely ZERO drug effect of any kind. I'm not attacking you, just observing this a pretty odd thing to assert, considering no one can tell these things on sight.


If none of the above issues were at play with you, and your friends all got off just as expectged, then the only answer I can come up with is: you are indeed some neurological mutant, and have to content yourself to other psychedelics, just fucked up luck guess, too bad, how sad.
 
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Assuming you have real drugs (which is a big assumption), maybe you just need to escalate your dose. I personally need highish doses of 2C-drugs to really get somewhere i'd consider worthwhile (35-50mg of 2C-B for instance) ... but I'd feel something at lower doses. This leads me to believe that perhaps you do not have real drugs.
 
MagickalKat777 said:
^^ SSRIs increase phen effects... at least with 2C-T-2
Click to expand...

Not quite. Actually, not at all- SSRI's generally dull the effects of 5HT agonist drugs. 2C-T-2 is somewhat diferent, as it mild MAOi properties, which makes it dangerous to combine with an SSRI.

That said, when I was on SSRI's, I never felt a decrease OR increase of effects. YMMV.
 
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