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What are the expected metabolites of 5-Me-MDA, 4-MMC, and methylone when used togethe

MagickalKat777

MagickalKat777

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Just as the original post says... I was up almost 50 hours while my partner was down a LOT quicker... but umm... there is a strong possibility that if the metabolites were excreted in urine that I ended up being flooded with metabolites (I'm not going into it)... I was tripping 50 hours later, including seeing a full blown forest grow out of the fireplace, the fastest tapesty of visuals I've ever seen when I was trying to work... Crazy stuff... and of course, my heart rate got a bit high.

I'm wondering if I ended up sucking down cathinone and methcathinone... it was a very dirty high and when it hit, there was a very distinct change in tone and I was very very alert but felt dirty. It was like methamphetamine in rolls but more lucid and slightly less rough on my heart...

Can anyone tell me what the suspected metabolites would be? The "ingestion" would have been about 6 hours into the experience and there were multiple exposures over the course of a few hours...
 
The methyl on 5-Me-MDA should be oxidized first to Ar-CH2OH then Ar-(C=O)-H then Ar-COOH. This is a difficult and time consuming process, and it becomes more electronegative at every step of the way.

The methylenedioxy ring of 5-Me-MDA should be metabolized into 3-MeO-4-OH-Ar (where Ar = aromatic benzene ring) and, to a lesser extent, 4-MeO-3-OH-Ar.

4-MMC's carbonyl group is reduced to a secondary alcohol, some of it is N-demethylated, and the Ar-CH3 goes to Ar-CH2OH then Ar-(C=O)-H then Ar-CO2H.

Methylone's carbonyl is reduced to a secondary alcohol as well by cathinone reductase, and its benzodioxole ring is cleaved as per 5-Me-MDA. Some N-demethylation takes place.

If any of these hang around long enough, the liver removes the N to yield a propanone. Further oxidation chews the compounds all the way up unless they are excreted first.

I don't know what would happen to the aromatic alkyl group in the case of 5-ethyl-mda or 4-ethylmethcathinone.
 
MagickalKat777 said:
... there is a strong possibility that if the metabolites were excreted in urine that I ended up being flooded with metabolites (I'm not going into it)...
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No idea about your question, but pleeeeeeaaase explain us that quote above! =D

- Murphy
 
para methyl ephedrine from 4mmc

its a dirty feeling of speedy roughness that you get the next day after a heavy meph binge, so if you were drinking your piss to get more out of the 5-me-mda then you probably drank 4methyl ephedrine which is speedy and dirty as hell
 
If what read was correct, 4-ME isn't speedy at all - at least not at the small doses that produce major vasoconstriction.
 
Hammilton said:
If what read was correct, 4-ME isn't speedy at all - at least not at the small doses that produce major vasoconstriction.
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yeah but when you eat a LOT of meph you have this really speedy feeling for nearly two days when you come down that feels very different from the initial drug feelings (feels like a very adrenaline type speed feeling). i assumed it was 4-ME, as ephedrine is speedy. with the amounts of meph people snort over a couple of days (multiple gram binges) it surely builds to active levels leading to speedy effects:)
 
"Surely" is hardly the word to use. The best you can say is "it might possibly."

I'm fairly certain that by the time you'd reach a stimulating dose of 4-ME (what a great name!) you'd be cutting limbs off limbs.
 
Come on MagikalKat, everyone wants to hear about your zany urination drinking antics!
 
Probably not a lot urine involved, but if my suspicions are correct, semen + mount and/or anus probably was the delivery mechanism. Sounds like fun! :D
 
Hammilton said:
"Surely" is hardly the word to use. The best you can say is "it might possibly."

I'm fairly certain that by the time you'd reach a stimulating dose of 4-ME (what a great name!) you'd be cutting limbs off limbs.
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yes a great name indeed

all i can say is that once the mephedrone effect wears off (after say 2-3grams snorted over a night or two) you are left with this speedy manic feeling for a day or two then this drops off to an empty, energy devoid, speed comedown feeling.

maybe its is vasoconstrictive to varying degree's in different people as seen by the random variation in how suceptible people are to nasty side effects. some people get terrible side effects after one dose others only after months of binging, some get none of the vasoconstrictive syptoms.

it certainly felt like there was some cheap speedy leftover in the mix, it was part of why it was so addictive as once the inital comedown was over you would feel great (full of enegry, and excited) for a day or two before feeling very tired and washed out. weird, as this pattern wasn't there for any other stim i tried and binged on.
 
God, this is why I love bluelight. There is always someone willing to drink his urine for science, and someone there to hypothesize about the results of the ingestion.

Here's a paper that will help out. It's all the metabolites of 4-MMC and Methylone. All you have to figure out is 5-Me-MDA, and you're good to go. The metabolites are a mess though, acetylated all over. Who knows what they do.

http://www.springerlink.com/content/2tx7406mj8103376/fulltext.html

(Here's another link in case that doesn't work) http://www.springerlink.com/content/2tx7406mj8103376/
 
Thanks a lot for that paper!! I would think that the acetylated metabolites are all more or less inactive.

- Murphy
 
MurphyClox said:
Thanks a lot for that paper!! I would think that the acetylated metabolites are all more or less inactive.

- Murphy
Click to expand...

No problem! That's exactly what I would have thought too, had the OP not reported staying up for 50 hours... That could just be from digesting the unmetabolized portions. He did say he felt a distinct change in the effects. More urine drinking is needed to know for sure, haha (for science)!
 
Here is the diagram from the link for those that are lazy.

nVxfP.gif


#5 was only detected in human urine.

Some of the metabolites should be active, such as 4-MC (4-Methylcathinone).
 
2 is definitely active, 3 & 4 probably too. The latter ones were made responsible for the nasty peripheral side-effects of 4-MMC.
 
MurphyClox said:
2 is definitely active, 3 & 4 probably too. The latter ones were made responsible for the nasty peripheral side-effects of 4-MMC.
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sweet this would explain why i felt speedy after effects yet didn't get bad symptoms compared to a lot of people on here. after a big binge you would feel like there was a new speedy drug taking over that would last a day or two before the real comedown of lethargy and emptiness would take over. it was like a two day delayed speed comedown which was bizarre and probably added to the addictiveness of the drug as people wouldn't get a proper exhausting comedown quick enough to associate it with the 4mmc:\
 
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