What actions is GABA responsible for...

[blase deviant]

...without the GABA-A receptor. I.e., take all the GABA actions, and then subtract the ones mediated by GABA-A and put them on a GABA-A list. If something is on both lists, for example, note on the 'main GABA list' that GABA-A is more responsible.

I've seen stuff for alpha, beta 1,2,etc, but not a comparison of A,B,C..

 

[BilZ0r]

actions? GABA-B and C receptors are generally presynaptic, inhibitory receptors... they inhibit hyperexcitablility and allow neuronal traffic to be tuned...

I don't really get the question, you can't really do neurochemical phrenology like that. The list you've seen which says what "effects" gaba-A subunits, is generally comment on drug effects dependent on them, while in the odd case, when they knocked the subunit out, the animal was probably highly likely to have seizures, so they said that the subunit was "involved" in seizures.

Drugs which have no effect when you have no GABA-B receptor: Saclofen, Baclofen.

 

[blase deviant]

Well, basically I was wondering how taking Valerian with alcohol would alter the effects.

I didn't want to drink a lot and get a hangover. I generally combine benzos, but didn't wanna use benzos that night because I'm trying to use less and do away with my tolerance.

 

[BilZ0r]

Well seeing as we don't know really know how either alcohol or Valerian acts, it would be very hard to say, but I strongly doubt the effect would resemble benzos that much.

 

[blase deviant]

I was also curious how mixing with benzos would work. Benzos normally increase the effect of all GABA, but in this case, there'd be less GABA(A) effect, and more of the others (since the GABA has to go somewhere, more will be left to go into the others, I assume).

 

[BilZ0r]

huh?

Why will their be less GABA-A effect?

 

[5-HT2]

^^^there won't be less of a GABA-A effect, but more of one if you add benzos on top.