what about THIS kind of 'RC'?

[moracca]

Ok, so after looking through most of the clever RC tryptamine variations, one thing stands out to me. All of these compounds have 2 seperate chains attached to the nitrogen atom. (for example, 4-hydroxy,DImethyl-T, or 4-ho-DIisopropyltryptamine) My question is this, why can i find no information about compounds that have only one carbon chain coming off the N, with the other chain replaced by a hydrogen atom. for example, 4-hydroxy,N,N-methyl-T (shown in attatched image), or 4-aco,N,N-isopropyl-T. Is there some reason that this sort of compound would be inactive? I just haven't been able to find anything about them, and would appreciate those of you with a bit more knowledge on the subject to chime in and let me know the error of my logic.


Also... the second image is another offshoot idea I had while thinking about this question... I kind of doubt that it would be possible, or active, but then again, why not? any help is appreciated. Thanks!

 

[slopoke]

I have no idea about this but you should have posted it in the 'clever new RC suggestions 2006' thread over in psychedelic drugs forum.

Ideas are always good though

 

[moracca]

well, i guess i'll double post it over there, and mods, if need be, plz close this thread.

 

[Black]

[...] 4-hydroxy,N,N-methyl-T (shown in attatched image), or 4-aco,N,N-isopropyl-T [...]

they would be called '4-hydroxy-N-methyl-T' respectively '4-AcO-N-isopropyl-T'

 

[fastandbulbous]

they would be called '4-hydroxy-N-methyl-T' respectively '4-AcO-N-isopropyl-T'

No, as beta carbolines, the positional number for the OH group would be different (5-hydroxy-1,2,3,4-tetrahydro-beta-carboline)

 

[Jamshyd]

Ah I wish I saw this before I commented in PD. WhatI was trying to say there is the same as what F&B said here, only better than I would have .

 

[BilZ0r]

I thought we'd get more from you FnB... How about the SAR? Would this make it too flat? I think it would be a bit innactive... wouldn't it... because that ring nitrogen puts the usual ethyl amine in the wrong place

Also, I had to use ChemSketch, and it sucks balls. How doe one get ChemDraw for free?

 

[fastandbulbous]

Yeah, but all of the beta-carboline alkaloids are pretty piss poor psychedelics on their own. The harmala alkaloids have more in common with drugs like yohimbine & ibogaine rather than classic psychedelics in their subjective effects (more dream images/hypnotic type change of conciousness/state rather than the wide awake changes in cognative ability and sensory perception that typifies LSD, psilocin, mescaline etc.).

Beyond that, I don't have much SAR data about the beta-carboline & the more complex indolic alkaloids. If you want to call them hallucinogens, I think they're best classified as 'miscellaneous others' (aka weird fuckers!)

 

[Limpet_Chicken]

Actually Fast, I tried harmala, at a fairly high dose rectally, (an infusion, not chopped up seeds of course), while on ether, and the I found the effects very pleasant, not intense like say, psilocybin, yopo or other tryptamines, but a dreamy visual, and very relaxing state (I'm not so sure how much the ether had to do with that subjectively, but its not like they were going to interact pharmacologically).

 

[EN21]

ß-carbolines are fascinating compounds that can interfer with so many proteins, but as hallucinogens, I think they are not the of much interest.
The 6-MeO-N-isopropyl-THßC, which is analogously to 5-MeO-MIPT is inactive at 40 mg. Simple 6-MeO-THßC (pinoline) is a MAOI and also a very potent SSRI. I know of no human trials. In rats it exhibits antidepressive effects, -No wonder!