unilateral intranasal adminsistration of psychoactive substances

[crOOk]

Hi there!
I recently found this:

http://www.blackwell-synergy.com/doi/abs/10.1046/j.1471-4159.1997.68010233.x

Because the effect of intranasal l-DOPA on neostriatal dopamine was observed only ipsilaterally but not contralaterally to the side of intranasal drug administration, it can be hypothesized that l-DOPA was not effective via passage through the circulation but may have acted through a neuronal or an extraneuronal route.

Now my question to the experts: Do you know of any studies done regarding unilateral administration of other psychoactive substances that resulted in an unilateral increase of receptor activity? Has anyone ever experienced a difference in adminstering a substance to the left/right nasal passage only? Thanks for taking your time.

 

[BilZ0r]

Interesting observation, however, on reading the full paper, this was a result specific for L-DOPA. With cocaine and amphetamine, the effect of administration up a single nostril effected the whole brain.

This probably has something to do with the fact that L-DOPA uses endogenous transporters to get around, while the other two just diffuse; OR it's to do with the simple physiochemistry.

 

[crOOk]

Yeah, I noticed that it was an observation made specifically with Levodopa. I was just wondering if this could happen with other substances as well. Or maybe the concentration reaches higher peaks in one hemisphere at an earlier point after administration. This would probably be difficult to measure, but maybe there have been observations like this with EEG's... Ah well, if noone in here knows, I won't find many others who do. Haven't had much luck on pub med either.

Btw, the fact that levodopa is utilizing other transport mechanisms is interesting to me. Do you know of any other psychoactive drugs that use endogenous or exogenous transport vehicles?
I know it is theorized that DMT is utilizing Yuremamine (not endogenous but possibly still a transporter) to cross the BBB without being harmed by enzymes. But besides that I don't know of any substances which do this...

 

[kidamnesiac]

thc?

 

[vecktor]

Btw, the fact that levodopa is utilizing other transport mechanisms is interesting to me. Do you know of any other psychoactive drugs that use endogenous or exogenous transport vehicles?
I know it is theorized that DMT is utilizing Yuremamine (not endogenous but possibly still a transporter) to cross the BBB without being harmed by enzymes. But besides that I don't know of any substances which do this...

gabapentin is moved by an amino acid transporter,
some quaternary amines are moved by the choline transport system, can't think of which ones at the moment, but I remembered them because they looked too polar to cross by passive diffusion but were centrally active.