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Ultra-rapid metabolizer of CYP2D6..

Spadez87

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Feb 2, 2013
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I am an Ultra-rapid metabolizer of CYP2D6.. i take most opiates and get very negative side effects... SSRIs i go nuts.. i basically need very little of any drug legal or otherwise to gain effects. Does this mean i can do drugs less "safely"

What drugs can one take who is a Utra-rapid like myself? Can i still take drugs just less?

Lots of things are making sense from past now regarding illegal and legal drugs..
 
Check this list:
http://en.wikipedia.org/wiki/CYP2D6#Ligands

Substrates would be the ones to look out for.

Also:

CYP2D6 shows the largest phenotypical variability among the CYPs, largely due to genetic polymorphism. The genotype accounts for normal, reduced, and non-existent CYP2D6 function in subjects.
The CYP2D6 function in any particular subject may be described as one of the following:[5]
poor metabolizer – little or no CYP2D6 function
intermediate metabolizers – metabolize drugs at a rate somewhere between the poor and extensive metabolizers
extensive metabolizer – normal CYP2D6 function
ultrarapid metabolizer – multiple copies of the CYP2D6 gene are expressed, and therefore greater-than-normal CYP2D6 function
A patient's CYP2D6 phenotype is often clinically determined via the administration of debrisoquine (a selective CYP2D6 substrate) and subsequent plasma concentration assay of the debrisoquine metabolite (4-hydroxydebrisoquine).[6]
The type of CYP2D6 function of an individual may influence the person's response to different doses of drugs that CYP2D6 metabolizes. The nature of the effect on the drug response depends not only on the type of CYP2D6 function, but also on the extent to which processing of the drug by CYP2D6 results in a chemical that has an effect that is similar, stronger, or weaker than the original drug, or no effect at all. For example, if CYP2D6 converts a drug that has a strong effect into a substance that has a weaker effect, then poor metabolizers (weak CYP2D6 function) will have an exaggerated response to the drug and stronger side-effects; conversely, if CYP2D6 converts a different drug into a substance that has a greater effect than its parent chemical, then extensive metabolizers (strong CYP2D6 function) will have an exaggerated response to the drug and stronger side-effects.[7]

I'm not how else to put it, but you are clear that it is not CYP2D6 that you metabolize very fast but it is the CYP2D6 enzymes you metabolize fast WITH since they are overabundant. That would cause fast accumulation of metabolites of certain drugs which apparently can yield side-effects that are normally spreaded and attenuated.
 
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Spadez, did you have genetic enzyme test done? I'm waiting on the results of mine but I'm wondering if I don't have over-active CYP2D6 as well because I have really odd toxic reactions to a lot of chemicals metabolized by CYP2D6 myself.

It will be interesting to see how that test comes back. I'm not sure which markers they're testing for but I know that they're testing my liver and kidney enzymes through gene expression. I'm amazed Medicaid covered the test to be honest.
 
You should be ultra-sensitive to the effects of Codeine:

Codeine intoxication associated with ultrarapid CYP2D6 metabolism.

As an ultra-rapid metabolizer you should be LESS sensitive to the effects of most drugs broken down by CYP2D6, except in cases where there's an active metabolite (like with codeine).

There are a lot of reasons someone could be hypersensitive to many psychoactive drugs, I wouldn't be surprised if your CYP2D6 phenotype isn't the whole story here.
 
hey Kat, Im Canadian and even got paid 20 bucks to to the test through CamH in toronto. Yeah it was a "Liver Enzyme Cytochrome P450 gene test for drug metabolizing capacity" I hope your not like me as i looked up this stuff a bit and literally most drugs illegal or legal run through CYP2D6. (figures im bipolar and have shit knees)

So im guessing this means i cant use most drugs anymore..? i was looking to start dabbling in drugs like opiates/amphetamines but i guess that would be suicide.. i used to mainly do E or MDMA but apprently its not bioactive in CYP2D6 (prob why im not dead)

Im just wondering if i can use drugs like opiates/amphetamines that are quite active in CYP2D6 just in small small doses but i guess that would be playing with fire.

Thoughts?
 
You should be ultra-sensitive to the effects of Codeine:

Codeine intoxication associated with ultrarapid CYP2D6 metabolism.

As an ultra-rapid metabolizer you should be LESS sensitive to the effects of most drugs broken down by CYP2D6, except in cases where there's an active metabolite (like with codeine).


There are a lot of reasons someone could be hypersensitive to many psychoactive drugs, I wouldn't be surprised if your CYP2D6 phenotype isn't the whole story here.


Im just trying to understand more so i dont kill myself by accident. Your saying i could take higher doeses of drugs like Oxycodone then most people which just stays as oxy but not codiene which turns to morphine. Correct? Btw about the psychotropic drugs sensitivity your prob right as i am bipolar.

I sent you a PM btw with the same question just trying to find a answer because this is depressing the shit out of me.
 
Try not to think about it too much. Bipolar alone is a bitch (I've been diagnosed as a rapid cycler and as being cyclothymic)...
 
Try not to think about it too much. Bipolar alone is a bitch (I've been diagnosed as a rapid cycler and as being cyclothymic)...

yeah i try not to think about it, but im at the point where life is boring as fuck and i have not used any hard stuff but coke in 6 years and want to use maybe a 5 mg perc here and there. I always had bad reactions to drugs like coke and opiates but im pretty sure it was just panic attacks and sever anxiety brought out from 4 years of massive E use and 14 years of pot(im done with the pot as of Oct 2013 because it was making me nuts for a couple days at time suddenly)

Yeah i feel your pain, Its a massive bitch. I act like quite the idiot at times. ive been dealing with the bipolar for about 10 years id say (im 26) but just got diagnosed.
I to am a rapid cycler. ANGER.DEPRESSED.LAUGHING.etc etc changing over 24 hours on repeat is killing me/killing the the people around me
 
I wouldn't be surprised if your CYP2D6 phenotype isn't the whole story here.

Fluctuation in enzyme "speed" is incredibly rare and, more than likely, if you haven't ever been told by a doctor that you have enzyme issues - then you don't have it.
 
Fluctuation in enzyme "speed" is incredibly rare and, more than likely, if you haven't ever been told by a doctor that you have enzyme issues - then you don't have it.

It's actually not as rare as you may think. This is new medicine that will change how doctors prescribe and select drugs for patients. There are people with "normal" extensive metabolisms, intermediate, and ultra rapid. Ultra rapid is indeed the most rare by far. Extensives make up around 65-70 percent of of the world. Leaving up to 30 percent of us with either less active or more active enzymes leading to possible sever complications.
 
It's actually not as rare as you may think. This is new medicine that will change how doctors prescribe and select drugs for patients. There are people with "normal" extensive metabolisms, intermediate, and ultra rapid. Ultra rapid is indeed the most rare by far. Extensives make up around 65-70 percent of of the world. Leaving up to 30 percent of us with either less active or more active enzymes leading to possible sever complications.

Could you provide a source? Because I literally just read something that said exactly the opposite - that the phenomena exists in everyone, but having an ultra-rapid or ultra-slow metabolism is quite rare.

Again, unless you have a diagnosis from a doctor - the likelihood of you having an enzyme disorder is literally none.
 
Again, unless you have a diagnosis from a doctor - the likelihood of you having an enzyme disorder is literally none.

You'd only know if you take certain prodrugs or drugs that are primarily metabolised via CYP and there are anomalous effects. It's not statistically impossible, but variation in liver CYP expression are definitely observable.

It is safest to just assume that you have functioning enzymes unless you've had it tested, though.

http://www.ncbi.nlm.nih.gov/pubmed/19514967
http://www.ncbi.nlm.nih.gov/pubmed/23333322
http://www.ncbi.nlm.nih.gov/pubmed/22139682
 
You seem to have the opposite reactions to drugs than I do. Maybe I have read the info incorrectly. I need to take twice what most people do to have ANY effects. Most opioids wear out quickly and leave me in the same pain. I have chronic pain due to a back injury that is not operable. So I do physical therapy and go to pain management. Both have helped, but nothing really works.
Now the DEA in it's infinite wisdom, has decided to have a "one size fits all" use for drugs. My medicine has been reduced by 1/3 and my pain levels are ridiculous. How can others like me band together and try to change this?
 
unless you have a diagnosis from a doctor - the likelihood of you having an enzyme disorder is literally none.

In Swedish Caucasians the frequency of subjects having duplicated/multiduplicated genes is about 1–2% [34]. Going south in Europe, the reported frequency increases to 3.6% in Germany [35], 7–10% in Spain [36,37] and 10% on Sicily in Italy [38]. The frequency is as high as 29% in black Ethiopians [30] and 20% in Saudi Arabians [39].

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1874287/

Explains why those Saudis aren't big into drugs, right? :D

Yes maybe also considering fuck-all grows there in the desert making this perhaps more likely as a compensation mechanism?? Epigenetics to add even?

Maybe that's not the same mechanism as for the Sicilians... for them (I've been there) maybe more likely just greedy mobsters :>
 
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