Tyrosine Tolerance Mechanism?

[BananasAndOranges]

NMDA antagonists work better to prevent the formation of tolerance, but yeah, they should help a bit, particularly when combined with breaks from stimulants.

Really, you need a break from stimulants and then to take them far less often. You just can't sustainably take these agents daily, or even as often as weekly.

ebola

dude seriously hush. I hate when people say you need breaks. YEA THEY WOULD BE NICE, but most of us on them do not get high we need them as a maintenance drug, or for real focusing issues for day to day tasks that MUST be followed out. What the fuck other options are there? Meth? Coke? Those are illegal 8)8)8)

 

[Tommy6565]

BananasAndOranges. Do you have something that has maintained your focusing issues and prevented tolerance?

 

[DJHENRU]

I have maybe some insight...

I got some DLPA once, I couldnt really take any more then a couple pills, and it made me feel farely horrid/placebo. Just alot of laying around, ?till the effects passed? and then a bit of a groggy elated feeling perhapse.

Then I tried it with opiates(poppy seed tea specificly) to potentiate them. With a bit of potentiation going, I could not only feel I could stand taking a couple, shit I could take handfulls! & Boy oh boy was that potentiation good! So warm and toasty feeling, in fact unique this way!

The same kind of goes with 5htp, although Ive had experiences potentiating or softening the effects of X, there where times where I took it way seperate from X abuse.

It seemed of course to not do anything, UNTILL I had some cannabis, and then guess what? MUNCHIES OF THE GODS!

Ive used l-dopa(I think there is a bit of overstating of the negative effects, but it isnt as benificial really at all as well) there was a bit of a psychotic aspect(I was having cognitive problems from a head injury and stimulant abuse.)

It still seemed to have some nootropic/antidepressant benifits combined with recetams, & really amazing dream that where like psychology sessions freeing addictive qualitites through self examination. There was just one time with MASSIVE overdose of it with blood pressure changes, I WOULDNT WISH ON MY WORSE ENEMY, although it was extremely short lived, and didnt seem to provoke anxiety.

I'm sorry this went on too much, I seriously would investigate futher dietery/lifestyle changes that effect neurochemistry related to the above subjects.

 

[ebola?]

dude seriously hush. I hate when people say you need breaks. YEA THEY WOULD BE NICE, but most of us on them do not get high we need them as a maintenance drug, or for real focusing issues for day to day tasks that MUST be followed out. What the fuck other options are there? Meth? Coke? Those are illegal.

I'm in a bad enough mood to pull the credential card: given my experiences researching ADD in a cognitive psychology lab, I believe daily stimulants appropriate for nearly no one. Just because something comes from a doctor or is demanded by an unjust economy doesn't make it healthy.

ebola

 

[ziddy]

I'm in a bad enough mood to pull the credential card: given my experiences researching ADD in a cognitive psychology lab, I believe daily stimulants appropriate for nearly no one. Just because something comes from a doctor or is demanded by an unjust economy doesn't make it healthy.

ebola

Would you care to elaborate on this? Do you mean stimulants in any dose? I just can't really agree...I've had problems with stimulants in the past, but have benefited greatly from a regular therapeutic dose of Vyvanse recently. I don't really see much reason to think that a low dose of amphetamine is necessarily more harmful than abusing caffeine like a lot of understimulated people would be otherwise...

 

[ebola?]

The main issue is that consistent treatment regimens tend to be unsustainable. For most individuals, tolerance accrual will eliminate effectiveness in about 2 years (even with dosage increased to limited maximums for prescription) for most people. However, if a low dose retains effectiveness for you over a long period, more power to you.

ebola

 

[omegapoint]

Just because tyrosine is a precursor for dopamine doesn't mean that oral tyrosine supplementation has any effect on brain DA concentrations. In fact, I'm fairly positive it has virtually no such effect.

This is something that's probably linked to placebo. Libido is so incredibly intertwined with expectation and mindset that it'd be very, very difficult for any evidence to the contrary suggest that it isn't placebo.

http://jop.sagepub.com/content/13/2/144.full.pdf+html

http://proquest.umi.com/pqdlink?Ver=1&Exp=02-29-2016&FMT=7&DID=984905341&RQT=309

http://web.ebscohost.com/ehost/pdfv...a8e8-4235-b6ed-1a3b14978bdc@sessionmgr4&vid=2

 

[jwt8]

Tyrosone/Phenylalanine Tolerance

Tommy, your tyrosine response resonates with me. I believe Tyrosine/Phenylalanine has a huge your-mileage-may-vary component, for whatever reason based on responses in me vs. in other people.

Around 1990, when I was a teen-ager, my father had just finished going back to school for a second degree in engineering (after spending most of his life as a mechanic). As an older person, he found calculus & physics to be more challenging the second time around, compared to his younger days. He heard about phenylalanine & choline, tried them, and found them to be a miracle for getting through his classes. So he recommended that I try it, and being a teenager, I responded "yeah, whatever".

So I tried it, very skeptically. It was because of my phenylalanine response that I'm an avid supplement user until this day (many other supplements have joined the list, all for the good). There was a point in the response where it was impossible to deny that something was going on. I'm sure that people who try cocaine, meth, marijuana, LSD, etc, will laugh if you seriously argue to them "it's probably placebo". It was the same kind of clear sensation.

I switched from being pure introvert to being the center of attention and quite funny. I felt very alive, and occasionally actually high. It lasted for maybe 9 months to 1 year. Eventually, the stuff would no longer work. Not like withdrawals or addiction or whatever, just stopped working.

I believe it left me with a permanent change for the good, although the major effects faded. I stopped taking it about 15 years ago, and every now and then will try it, to no avail. My body got what it wanted, and it's done with it.

Like you, I'm deeply curious about the mechanism. I've tried just about every other brain supplement since, and many work well and continue to work for me, without this kind of tolerance issue. But none are the level of intensity and effectiveness that phenylalanine (or tyrosine also) had for me.

I've recommended phenylalanine to at least 5 different people. None had the response that I had. Some said it made them irritable/aggresive. Many said no effect. One saw a mild positive effect. It's crazy to me, because the effect should definately be noticeable, according to my experience.

So my conclusion is that rather than me developing a tolerance, I probably had a kind of defeciency. I think it kind of explains some of my pre-teen misfit/dorky behavior, which straightened out post phenylalanine.

 

[paranoid android]

Hmm i take 300mg's of bupropion everyday (along with other meds i take for bipolar) and on a few occasion ive taken L-tyrosine with b-vitamines to kinda give me a lift. On one occasion this set off a manic reaction that even olanzapine and risperidone together had a hard time getting under control . I had not taken any stimulants in months and i don't even drink coffee so ya i think theres something to l-tyrosine.

 

[hamhurricane]

The effectiveness of Tyrosine supplementation, like most supplementation, seems very much dependent upon the users need for it. If you are ingesting insufficient quantities of dietary tyrosine or phenylalanine, supplementation may help enormously for some time until the deficit is corrected. As simple as that. Ascorbic acid will prevent scurvy, yet taking mega-doses for years at a time will not give you gums of steal. Iron will prevent fatigue from anemia, yet taking it continuously will not give you more energy. You can only benefit as far as a deficiency is corrected. The same can be said for biosynthetic catecholamine precursers like tyrosine.

When I am under large amounts of academic or work related stress I find taking AA doped whey protein to be tremendously helpful, in part because a dose contains several grams of tyrosine, if I miss a dose of whey under stress I really notice the difference, on a normal day––not so much.

The effects of tyrosine on cognitive performance during extended wakefulness.

Tyrosine administration was associated with a significant amelioration of the usual performance decline on a psychomotor task and a significant reduction in lapse probability on a high-event-rate vigilance task. The improvements lasted on the order of 3 h. The results of this study also suggest that tyrosine is a relatively benign treatment at this dose. After further testing with other doses and timing of administration, tyrosine may prove useful in counteracting performance decrements during episodes of sustained work coupled with sleep loss.