TRT, Changing Dose & Being Contradicting IM Sites

Gaz_hmmmm

Gaz_hmmmm

Bluelighter
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I'm on Test' replacement and the last 2 times I've gone in the outside of my thighs. Now my results have came back and they're wanting to change my dose from once every 12 weeks to 10, but I think it's it's cause of where I went not because my body/metabolism as changed.

Should I just get it every 10 weeks or sort it out? :-/
 
Is it the same dose but 10 weeks instead of 12 ? If so, get it. Who doesn't want more test ?
 
Gaz_hmmmm said:
I'm on Test' replacement and the last 2 times I've gone in the outside of my thighs. Now my results have came back and they're wanting to change my dose from once every 12 weeks to 10, but I think it's it's cause of where I went not because my body/metabolism as changed.

Should I just get it every 10 weeks or sort it out? :-/
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From your injection protocol I would assume you're using Reandron 1000mg... The information fact-sheet (below) states your doctor may decide to switch to 10 weeks or less after the first injection, apparently to obtain more stable blood concentrations sooner...

http://www.medsafe.govt.nz/Consumers/cmi/r/reandron.pdf

Glute injections are recommended.. More bio-availability I believe than quads or delts..? Bioavailability A measure of the amount of drug that is actually absorbed from a given dose.


To quote Big Cat:
Interesting point from Minto et al: Injection site and volume do not seem to affect half life, but for some inexplicable reason the glute 1ml deca shot had a much higher bio-availability (AUC of 78% I think to 53-56% for the other three treatments, quad, delts) For whatever reason injecting the lower volume in the bigger muscle resulted in more of the drug being taken up in the system.....


http://jpet.aspetjournals.org/content/281/1/93.full


More on Reandron 1000:

Comparison of a new long-acting testosterone undecanoate formulation vs testosterone enanthate for intramuscular androgen therapy in male hypogonadism.
Minnemann T, Schubert M, Freude S, Hübler D, Gouni-Berthold I, Schumann C, Christoph A, Oettel M, Ernst M, Mellinger U, Krone W, Jockenhövel F.
Source
Clinic and Outpatient Department of Internal Medicine, University Clinic, Cologne, Germany.
Abstract
OBJECTIVE:
To assess the efficacy and safety of a novel long-acting im testosterone undecanoate (TU) formulation in comparison with testosterone enanthate (TE).
SUBJECTS AND METHODS:
An open-label, randomized, prospective clinical trial in 40 hypogonadal men (baseline serum testosterone levels <5 nmol/l), randomly assigned to 250 mg TE/3 weeks (no.=20) or 1000 mg TU im every 6 to 9 weeks for 30 weeks (no.=20). Subsequently, 32/40 men continued the study for another 114 weeks, now receiving TU 1000 mg/12 weeks.
RESULTS:
TU and TE produced no statistically significant improvements in grip strength over the first 30 weeks, which only occurred after approximately 90 weeks when all subjects received TU. There were no changes in body mass index with TU and TE, neither in the follow-up period when all patients received TU. But ratios of waist to hip circumferences declined in the longer term. Total serum cholesterol, LDL cholesterol, and triglycerides declined over the first 30 weeks, while plasma HDL also declined. Plasma LDL decreased further under long-term TU therapy, while HDL then increased. Hemoglobin and hematocrit values significantly increased over the first 30 weeks in both treatment groups and then no further increase was observed. Levels did not exceed the upper limit of normal. In both treatment groups, serum prostate specific antigen levels rose slightly after 30 weeks, with no further increase over the first 12 months, remaining stable within the normal range. Plasma T before the following TU injection was above the lower limit of reference values. Four injections per year are adequate.
CONCLUSIONS:
Administration of TU every 12 weeks is at least as safe and efficacious for treatment of hypogonadal men as TE, with a substantially lower frequency of administration. Follow-up over 114 weeks, when all subjects received TU, showed an excellent profile of efficacy and safety.

http://www.ncbi.nlm.nih.gov/pubmed/18852533

Intramuscular testosterone undecanoate: pharmacokinetic aspects of a novel testosterone formulation during long-term treatment of men with hypogonadism.
Schubert M, Minnemann T, Hübler D, Rouskova D, Christoph A, Oettel M, Ernst M, Mellinger U, Krone W, Jockenhövel F.
Source
Klinik II und Poliklinik für Innere Medizin der Universität zu Köln, Germany.
Abstract
In an open-label, randomized, prospective trial, we investigated pharmacokinetics and several efficacy and safety parameters of a novel, long-acting testosterone (T) undecanoate (TU) formulation in 40 hypogonadal men (serum testosterone concentrations < 5 nmol/liter). For the first 30 wk (comparative study), the patients were randomly assigned to receive either 10 x 250 mg T enanthate (TE) im every 3 wk (n = 20) or 3 x 1000 mg TU im every 6 wk (loading dose) followed by 1 x 1000 mg after an additional 9 wk (n = 20). In a follow-up study, observation continued in those patients who completed the comparative part and opted for TU treatment (8 x 1000 mg TU every 12 wk in former TU patients and 2 x 1000 mg TU every 8 wk plus 6 x 1000 mg every 12 wk in former TE patients) for an additional 20-21 months. Here we report only the pharmacokinetic aspects of the new TU formulation for the first approximately 2.5 yr of treatment. At baseline, serum T concentrations did not significantly differ between the two study groups. In the TE group, mean trough levels of serum T were always less than 10 nmol/liter before the next injection, whereas in the TU group, mean trough levels of serum T were 14.1 +/- 4.5 nmol/liter after the first two doses (6-wk intervals) and 16.3 +/- 5.7 nmol/liter after the 9-wk interval at wk 30. The mean serum levels of dihydrotestosterone and estradiol also increased in parallel to the serum T pattern and remained within the normal range. In the follow-up study, the former TU patients (n = 20) received eight TU injections at 12-wk intervals, and the TE patients (n = 16) switched to TU and initially received two TU injections at 8-wk intervals (loading) and continued with six TU injections at 12-wk intervals (maintenance). This regimen resulted in stable mean serum trough levels of T (ranging from 14.9 +/- 5.2 to 16.5 +/- 8.0 nmol/liter) and estradiol (ranging from 98.5 +/- 45.2 to 80.4 +/- 14.4 pmol/liter). The present study has shown that 1000 mg TU injected into male patients with hypogonadism at 12-wk intervals is well tolerated and leads to T levels within normal ranges, using four instead of 17 or more TE injections per year. An initial loading dose of either 3 x 1000 mg TU every 6 wk at the beginning of hormone substitution or 2 x 1000 mg TU every 8 wk after switching from the short-acting TE to TU were found to be a adequate dosing regimens for starting of treatment with the long-acting TU preparation.

http://www.ncbi.nlm.nih.gov/pubmed/...+Long-Term+Treatment+of+Men+with+Hypogonadism
 
Do you think that perhaps muscle activation/use post-injection (ideally low intensity cardio, like jumping on a spin cycle or something and pedelling for a while) will increase BA due to increased bloodflow to the muscle and subsequently the area in which the oil compound is sitting? I've heard this somewhere, though it was only just touched on lightly.

Maybe the glutes showed higher BA due to being "used more" in general activity as opposed to quads, as per my above theory?

Hmm, if this is more than a yes/no answer, reckon it's worth its own thread GF?
 
I have never jabbed anywhere except from right glute, only other place I would ever consider is delts, my quads are absolutely solid and I imagine that would be painfull.
 
It depends man on how your built, the gear your using, how often you pin, the temperature when pinning ( i like to keep the gear in the bathroom when showering so it warms up, or hit it with a hair dryer a wee bit, I fine well made gear warmed up a bit flows nicely through a nice small gauge pin and makes for easy injections and a wider number of places to hit. ) I favor my right glute to but: I have hit a lot of places over the years.
 
Neoprimitive said:
It depends man on how your built, the gear your using, how often you pin, the temperature when pinning ( i like to keep the gear in the bathroom when showering so it warms up, or hit it with a hair dryer a wee bit, I fine well made gear warmed up a bit flows nicely through a nice small gauge pin and makes for easy injections and a wider number of places to hit. ) I favor my right glute to but: I have hit a lot of places over the years.
Click to expand...

Now that's a good idea.

I pin ED using a 25g 1" when blasting, cycling right then left side, v.glute > quad > calf. Pin the same muscle every 6 days. When cruising I still pin ED using a 27g 1/2" insulin syringe, but only into my quads.
 
yeah man, don't put that much reandron in your quad/thigh. but that in your glute...

it will hurt less.

have done quads alot myself, wouldn't do more than 2cc because omg you'll feel it every step, and it kinda affects workouts. best thing about quad is you got 2 steady hands. you could do 1/2 the dose twice the frequency if taking adv of those more sensitive area.

all other sites you really only got 1 hand.
 
I've had the absolute worst experiences with pinning glutes, though I'm fairly sure it was the gear as it would cork ANY muscle I pinned in a big way. Gear itself definitely worked, so I'm not sure what the issue was with the corking. It was just Test P from RBA (Aussie). Switched to Balkan Labs Test E and Tren A, no more corking. Am now using RBA labs gear again, but not their propionate - no corking (well, VERY minor)
 
if its any muscle its the gear

if its prop its prob from a test prob bladder, they hurt like hell, suggestion is cut it 50/50 with another non-hurting one, more likely test e in aus. give a small shake in the barrel before escaping the air for mixture and you should get away with using the rest of the prop without it crippling you.
 
it definitely puts you off using gear and separates the boys from the men those shots...
 
cityturbo said:
it definitely puts you off using gear and separates the boys from the men those shots...
Click to expand...

Guess that makes me a man haha, given I had to lower myself gently on chairs etc the following couple of days after pinning my glutes :P worst part was I had to move house almost entirely on my own while in this fucked up painful state lol
 
if you can mix it with other gear it will help your sanity. but the less oil in your body the better, as a rule of thumb.

edit: esp as you get older... and scar tissue can build
 
^ if you got sterile oil it can be used to dilute as well if you dont want to add another compound. Ive always heard of rough pip with prop ester.
 
just to cut it no, cause the prop bladder hurt stuff is only 100mg/ml, so cut it 50 and its 50mg/ml

usually prop is 200mg/ml ugl

putting 4x as much oil in your body every single injection for the same mg doesn't sit well with me...
 
trozzle said:
Do you think that perhaps muscle activation/use post-injection (ideally low intensity cardio, like jumping on a spin cycle or something and pedelling for a while) will increase BA due to increased bloodflow to the muscle and subsequently the area in which the oil compound is sitting? I've heard this somewhere, though it was only just touched on lightly.

Maybe the glutes showed higher BA due to being "used more" in general activity as opposed to quads, as per my above theory?

Hmm, if this is more than a yes/no answer, reckon it's worth its own thread GF?
Click to expand...

You are correct, I believe is down to increased blood-flow in that area... Well you are according to my manual on Pharmacology and Therapeutics...Lol.. :)
 
Ha! Well that's good I suppose. Will be making my shitty 5.2km morning ride around the lake much more useful then :) lol
 
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