Pharmacology Treating Opioid addiction with Ibogaine.

[MedicinalUser247]

I searched through the Forum and it said I'd didn't have privileges to reply there. So, I'm starting my own thread about the use of Ibogaine used to treat Opioid addiction. Tell me what you think about it after your done watching the Video I found on Youtube.

 

[daturetard]

She ended the video with "fda thinks bout 19 people died taking it, so uh, get the information you need before trying it." Lol
I'd really like to try this if there were a way to grow or get it in the USA.

 

[pnillyg]

I just did the Ibogaine treatment in Tijuana. I came off of 500mgs of OC. If anybody is curious about my experience let me know and I’ll give yall a play by play. I’ve done Ibogaine for opiate addiction 8 times (two “retreats”) total.

 

[Rickthesizzler]

I just did the Ibogaine treatment in Tijuana. I came off of 500mgs of OC. If anybody is curious about my experience let me know and I’ll give yall a play by play. I’ve done Ibogaine for opiate addiction 8 times (two “retreats”) total.

I would definitely love to hear about it, I’m trying to get information about it. I’m trying to decide if it is going to help me

 

[meeer]

As with any drug psychedelic or otherwise, i advise that you just don't put all your weight and hopes into it, otherwise like overhyping a experience you can be let down and not get everything you thought you might having put so much thought power into "This is gonna work" or "I hope to god this cures me" your already putting up an insanely high barrier to instant removal of not just need but feeling or craving at all for said substance and to often more than not, this is a not going to help the process and only hinder its already possible avenues of success.

None of this is to speak against the possibility of a fast near instant recovery in some people, and not to say this hasn't happened, however it is realistic to walk into this with an open mind and no expectations will go a long way in the experience.

 

[meeer]

She ended the video with "fda thinks bout 19 people died taking it, so uh, get the information you need before trying it." Lol
I'd really like to try this if there were a way to grow or get it in the USA.

If i remember correctly it only grows in 3 places on the planet all of which are in africa.

 

[daturetard]

If i remember correctly it only grows in 3 places on the planet all of which are in africa.

Yeah, sounds about right. Any conditions are reproducible if you try hard enough though.

 

[Opana313]

I don't have time to check the vid at the moment but Yeah I have always been interested..I hear you can just order the root bark or something of that sort and go from there..I think like a decade ago I was reading on here about ppl taking low to micro doses because it has antidepressant properties?
Please Correct me if I am way off.

I remember some dude having a show or youtube channel where he was the guru and he actually had a "patient?" who freaked the fuck out on it like exorcist screaming & flailing all night ..I believe he shut down cameras and possibly had to get that guy an ambulance.

All aside though..when I listened to the ibogaine trip report on joe rogan experience, it sounds like an amazing yet difficult trip that I would enjoy to adventure some day soon.

 

[pnillyg]

I wouldn’t do it alone. Just my two cents. I’ve done it “underground” as well as in a “professional” setting in Mexico. Both worked for my opiate addiction. The primary goal with the medicine when treating addiction is getting a certain amount of MG per KG. That being said its different for everybody. I had better results when doing moderate doses called “lay-downs” multiple times a week for 3 weeks with the collective amount being the same as it would have been doing a “flood” which i have also done. One time i was coming off of 16mgs of bupe and the flood was coming off of 500mg of OC. You cannot do a flood on bupe due to its long half life or at least what they have told me.. hope this helps

 

[canadianpeduser]

I’ve heard so much about it but never been able to get my hands on it personally here in Canada. Have heard it’s a long trip. But well worth it to try

 

[Neuroprotection]

Ibogaine is an amazing compound in regards to its multimodal mechanisms of action, although given my extreme aversion to psychedelics, I would never consider ingesting it.
It is a potent classical serotonergic psychedelic with powerful NMDA antagonist and kappa opioid agonist effects. these contribute to the immediate trip/hallucinogenic actions and possibly the short-term anti-addictive effect.
Furthermore, its metabolites have significant SSRI activity which could decrease impulsivity.
Finally, one of the metabolites is an antagonist of certain nicotinic receptors which can provide additional anti-addictive action, I believe by suppressing dopamine output in response to drug cravings.

 

[meeer]

Yeah, sounds about right. Any conditions are reproducible if you try hard enough though.

Ohh quite right friend, I got peruvian arjis growing wildly well.

 

[3DQSAR]

At the end of the William S. Burroughs classic 'Junkie' he suggests that he wants to visit South America to find Yagé (Tabernanthe iboga.) and indeed there is a collection of his letters from the period entitled 'The Yage Letters'.

It seems that over recent decades the fact that there are two distinctly different plants both used for their anti-addictive properties is getting a little confused.

If memory serves there are also a few semi-synthetic compounds that have also been trialled in the treatment of addiction.

I'm just not a huge fan of any of the 5-methoxy tryptamine derivatives because they appear to cause some extremely unpleasant side-effects in some people. I'm also aware that at least some people selling what they claim to be DMT is actually a mixture of DMT and 5-MeO DMT. The latter evidently being cheaper to source as well as being more potent on a weight-for-weight basis.

 

[jambabomba]

Is Ibogaine so dysphoric with that strong kappa agonism that it causes massive and rapid upregulation of mu opioid system through that? Like being whole night in hot sauna? Or repeating sauna and cold baths whole night? Agonism of kappa causes upregulation of mu receptors.

That is what I have started to think when I've heard about this substance and its effects on its users.

Edit: I meant same kind of principle that they have used to withdraw heroin addicts with ice cold baths. That strong and sudden dysphoria makes you let go of your ego positions and concomitantly allows Grace to flow in and rapid upregulation of mu receptors through kappa agonism.

Or like SSRI medicines that stress the brains to dysphoric anxious states through excess serotonin and eventually glutamate and propably excitotoxicity, inflammation& cytokines, excess histamine, cortisol and so on. Then 2 weeks later receptors downregulate and mood is suddenly better after two weeks of constant stress.

Or ketamine for that matter. It also increases acutely very much glutamatergic tone and stresses the brains and activates compensatory anabolic pathways like mTor but only when that excitatory state have weared off and brain waves start to slow down and that is what correlates with the decrease in depression scores. Slow wave state of the brains (theta/delta) after excitatory stressed state.