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treating dopamine deficiencies

betsym said:
I didn't invent the term and apparently docs and researchers consider it a SEPARATE thing..or they wouldn't have named it, lol...ya think? of course all those docs, scientists, and researchers could all just be a bunch of quacks...if so, I married one, LOL!!
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Some researchers consider it a seperate thing. It is not something that has gained traction, and is not yet considered a valid diagnosis. Perhaps some day, but that is not today. I'd love to see an insurance companies response to being billed for RDS treatment. They don't like off-label medication, there's no way they'll like off-label meds for conditions recognized by very few.

First it was endorphin deficiency syndrome, now reward deficiency syndrome? This stuff always seems to be "discovered" by someone who has a book to sell or otherwise profit from it.

There is something that happens when people don't have enough DA or DA receptors, both of which seem to be indicated in the so-called RDS. It's called parkinson's disease.

here by the way, hammilton, does every reply you make have to have that cheeky snobby tone?
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Yes.
 
not havin a dig btw hamm, when i think of BL i think of you.

plus ADD is where its at when im doing my thesis! xxxx
 
btw am now trying selegiline plus phenylalanine as a therapy, its been a week now and iv noticed cock all.

really dissapointed, any1 had good results with this?
 
Not to talke this too far off topic, but I have a thread in trip reports about my experiences with selegiline + b-PEA.

My conclusions? Every bit as good as dexedrine, in some ways better. Heart rate left unchanged, blood pressure slightly lower, actually. Incredibly euphoria, even.

As I use it more and more, I love it more and more.

Besides, at a buck a gram, it's hard to beat.
 
closedeyevision said:
btw am now trying selegiline plus phenylalanine as a therapy, its been a week now and iv noticed cock all.

really dissapointed, any1 had good results with this?
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what form you getting the phenylalanine from? I hope not aspartame...that's cancerous (and a testament to the corporate domination of the FDA and the European Union counterpart). This is one of the few chemicals I try to actively avoid (I also do this with MSG to a lesser extent...although ramen noodles never seem to taste right without the MSG-heavy flavor packs).

I'm surprised you need supplementation of this amino acid, especially with selegiline. It doesn't sound like a good idea to keep doing in the long run, actually. Who recommended this combo to you?
 
when selegiline is used orally for depression it is in conjunction with l phenylalanine, theres plenty papers on it. This is because it is a precursor to PEA and DA.

the phenylalanine is from a well known health food store
 
OK, for depression...

it is a precursor to PEA, not dopamine, tyrosine is the direct precursor there

PEA will release DA similar to amphetamines so it works in a like manner but is '"less invasive"
 
Sure does. It almost entirely lacks the body load of the amphetamines. Better than dexedrine but with far short a duration. I've been keeping tabs on my HR and blood pressure, and neither have been effected by it. My heart seems to beat 'harder' but I don't know what that means without changes in HR or BP.
 
robcypher said:
(I also do this with MSG to a lesser extent...although ramen noodles never seem to taste right without the MSG-heavy flavor packs).
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Off-topic, but...

MSG isn't inherently harmful in and of itself, as it dissociates into glutamate upon reacting with water. I thing the problem with it comes from too much sodium being consumed along with an excess of glutamate (which I think could be excitotoxic?). I think that the same kind of harm that would occur from too much MSG could come from consuming too much soy sauce, which is salty and loaded with glutamate. The real difference lies in wholesomeness. Soy sauce brewing is an ancient art, and naturally fermented food is rich in many, many yummy and healthful compounds, where the production of MSG and soy hydrolysate is an industrial process, centered around the recycling of the waste (soy protein) of an vegetable oil industry that uses a lot of petrochemical in the form of hexane to extract an oil that cannot be pressed out of the seed in the way that many other vegetable oils can.

As such, I generally avoid all refined soy, or soy protein products, which wind up in a lot of processed food.
 
I doubt glutamate have much in the way of bioavailability, and I don't think the anion will cross the bbb.

I haven't looked into it yet, but I'd be surprised.
 
Hammilton said:
I doubt glutamate have much in the way of bioavailability, and I don't think the anion will cross the bbb.

I haven't looked into it yet, but I'd be surprised.
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That's why I put the question mark there. I thought it may not cross the BBB either.

Edit: it is regulated at the BBB, and doesn't cross it easily. Having looked into it, dietary glutamate isn't dangerous as an excitotoxin, I would reckon, all though some people have sensitivities to it. And most MSG these days is actually produced through fermentation then isolated, not by hydrolysis of soy. (i'd still rather use soy sauce)
 
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Magnesium works wonders... especially the highly absorbent kind like Magnesium Glycinate Amino Acid Chelate. You'll see a difference right away and it only gets better with time.
 
Hammilton said:
Not to talke this too far off topic, but I have a thread in trip reports about my experiences with selegiline + b-PEA.

My conclusions? Every bit as good as dexedrine, in some ways better. Heart rate left unchanged, blood pressure slightly lower, actually. Incredibly euphoria, even.

As I use it more and more, I love it more and more.

Besides, at a buck a gram, it's hard to beat.
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what's a buck a gram, the pea? where do you get selegiline from and how much is it?

Do you know if it would work on someone who previously abused amphetamines?
 
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