crOOk
Bluelighter
- Joined
- Dec 16, 2004
- Messages
- 4,047
So I'm a huge fan of Tramadol and stumbled upon this:
Note: Depicted are only the liver enzymes, not those cytochromes that are secreted into the GI tract or any other influences on the pharmacodynamics of Tramadol.
Both these CYP3A4 and CYP2B6 will increase the effects and the duration of a given Tramadol dose.
We all know how to inhibit CYP3A4, but how about inhibiting CYP2B6? Curcumine seems to be the most effective and easily available substance to do this. Has anyone ever tried it? I am getting over 100g 95% curcumine tomorrow morning (morning express delivery tehehehe) and will report back.
Also, does anyone know if there are ways to inhibit UGT2B7 or UGT1A8? I am just curious and not planning to do this since these enzymes (glucuronosyltransferases to be more precise) process some nasty exogenous and endogenous substances like bile acids and both male and female sex hormones (wouldn't want to eat soy on them^^). On top of that it would simply increase the duration which I am not interested in.
More importantly how dangerous would this be regardless of dietary restrictions, in other words only in respect to endogeous chemicals?
On a sidenote, it has been found that Tramadol occurs naturally in clinically significant amounts with concentrations of over 1% in the root bark of a tree that grows somewhere on the African continent. I am too lazy to provide the source, but it has apparently been used to treat pain and diarrhea for centuries by the tribes that had access to the tree and necessary information. I found this very interesting since it once again demonstrates how many natural remedies beyond those that we have already discovered contain substances of potential clinical importance!
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918523/
^Some further info on curcumin, it's a free review. All I can say is 'WOW'! It seems to have received attention by the science community in the last few decades but I hadn't heard of it. I had no idea how many clinically significant beneficial effects it has. Totally gonna slam it now.
Note: Depicted are only the liver enzymes, not those cytochromes that are secreted into the GI tract or any other influences on the pharmacodynamics of Tramadol.
Both these CYP3A4 and CYP2B6 will increase the effects and the duration of a given Tramadol dose.
We all know how to inhibit CYP3A4, but how about inhibiting CYP2B6? Curcumine seems to be the most effective and easily available substance to do this. Has anyone ever tried it? I am getting over 100g 95% curcumine tomorrow morning (morning express delivery tehehehe) and will report back.
Also, does anyone know if there are ways to inhibit UGT2B7 or UGT1A8? I am just curious and not planning to do this since these enzymes (glucuronosyltransferases to be more precise) process some nasty exogenous and endogenous substances like bile acids and both male and female sex hormones (wouldn't want to eat soy on them^^). On top of that it would simply increase the duration which I am not interested in.
More importantly how dangerous would this be regardless of dietary restrictions, in other words only in respect to endogeous chemicals?
On a sidenote, it has been found that Tramadol occurs naturally in clinically significant amounts with concentrations of over 1% in the root bark of a tree that grows somewhere on the African continent. I am too lazy to provide the source, but it has apparently been used to treat pain and diarrhea for centuries by the tribes that had access to the tree and necessary information. I found this very interesting since it once again demonstrates how many natural remedies beyond those that we have already discovered contain substances of potential clinical importance!
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918523/
^Some further info on curcumin, it's a free review. All I can say is 'WOW'! It seems to have received attention by the science community in the last few decades but I hadn't heard of it. I had no idea how many clinically significant beneficial effects it has. Totally gonna slam it now.
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