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Tramadol: How dangerous w/speed?

darvocet21

darvocet21

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Joined
May 31, 2021
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27,099
I've heard Tramadol can cause seizures due to its property of inhibiting serotonin reuptake, and the risk increases at higher doses

How about combining it with stimulants such as adderall or methamphetamine? Has anybody had or know of somebody suffering seizures from this combo?
 
Tramadol shouldn't be mixed with psychostimulants. It's not worth the risk, get a more traditional opiod instead if you want to experience a similar combo.

Tramadol + amphetamine may be OK if you aren't prone to seizures and take a low dose of each, but you're still increasing your risk. Adding a benzo could also offer some protection.
Avoid mixing it with methamphetamine and specially cocaine (even with benzos), the latter has killed many people.

Btw, tramadol seizures aren't directly related to its properties as an SSRI, it's more complicated than that. Although there's also a very real risk of serotonin syndrome (in addition to the seizure risk) when mixed with other serotonergic drugs.
 
I agree with 4meSM. Tramadol (Ultram) is well-known for its propensity to lower the seizure threshold, especially in dosages higher than 300mg in a single sitting. Likewise, Amphetamines and essentially, all stimulants that act in a similar fashion also will lower the seizure threshold.

Sure, if you are responsible and use reasonably low dosages of each drug, I'd wager that you will be fine. However, I'm filing this one under "not advised, proceed at your own risk". I really would feel better if you just didn't do this. I think you're kind of asking for trouble when perhaps you could get some different drugs that are less dangerous.
 
4meSM said:
Tramadol shouldn't be mixed with psychostimulants. It's not worth the risk, get a more traditional opiod instead if you want to experience a similar combo.

Tramadol + amphetamine may be OK if you aren't prone to seizures and take a low dose of each, but you're still increasing your risk. Adding a benzo could also offer some protection.
Avoid mixing it with methamphetamine and specially cocaine (even with benzos), the latter has killed many people.

Btw, tramadol seizures aren't directly related to its properties as an SSRI, it's more complicated than that. Although there's also a very real risk of serotonin syndrome (in addition to the seizure risk) when mixed with other serotonergic drugs.
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Appreciate your response
 
I did mix Tramadol with Amphetamine Sulphate for a while and also with 3,4FluoroPhenMetrazine (and maybe Ephedrine, but I'm sure not...oh and with Pseudoephedrine definitely and possibly Phentermine and possibly Clenbuterol).
Personally, it never created any issues for me but for sure it can be dangerous and I would strongly recommend against it.
 
I just want to add, if this was going to be a regular thing and you added a benzo, you are adding another level of risk for seizure from benzo withdrawal as well.

Id say all around it sounds like an extremely high risk idea to mix these substances.
 
Just thinking about this, Id avoid tramadol abuse altogether if possible unless absolutely medically necessary. I cant imagine how terrible opiate withdrawal would be with the added bonus of SSRI withdrawal. Sounds like a recipe for anhedonia on steroids.
 
Thanks everybody for such high-quality answers. Couple of things: I've never taken more than 100-125mg because it changes at that point for me to a dysphoria. I can't imagine swallowing multiple hundreds of milligrams at one time. Back when I had zero tolerance couple of years ago I found that 50 mg was plenty and especially liked the persistent effects that lasted the better part of a day. Even taking kratom at moderate doses significantly reduces the Tramadol experience... however on a day I take it I have no desire to use kratom and feel completely normal. Notable but not exceptional since I've gone several days without Kratom and suffered little discomfort...even though I wasn't 100% I was able to go about my business. Has anybody utilized Tramadol for detoxification off stronger opioids?
 
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You’re replacing an opioid with an opioid that also acts like an SSRI so withdrawing from tramadol is withdrawing from both. It’s really unpleasant. I would taper down.

What is the stronger opioid you’re referring to if you don’t mind me asking @darvocet21
 
MsDiz said:
You’re replacing an opioid with an opioid that also acts like an SSRI so withdrawing from tramadol is withdrawing from both. It’s really unpleasant. I would taper down.

What is the stronger opioid you’re referring to if you don’t mind me asking @darvocet21
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I have no personal experience with this but here is an excellent and I believe trustworthy report of successful use of Tramadol for detox off prescribed high-dose oxycodone by a former nurse:

 
MsDiz said:
You’re replacing an opioid with an opioid that also acts like an SSRI so withdrawing from tramadol is withdrawing from both. It’s really unpleasant. I would taper down.

What is the stronger opioid you’re referring to if you don’t mind me asking @darvocet21
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Perhaps the clue is in his name? Dextropropoxythene?

I much prefer that to tramadol any day...
 
darvocet21 said:
I have no personal experience with this but here is an excellent and I believe trustworthy report of successful use of Tramadol for detox off prescribed high-dose oxycodone by a former nurse:

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Ughhhh... honestly, I’d use codeine if I was going to taper off with something else. Tramadol is such a dirty drug. When you stop it you’re stopping taking an SSRI, that comes with all the wonderful head zaps etc etc as well as the residual opioid withdrawal.

nahhh... I wouldn’t advise it but.., sometimes people need to find out themselves.
 
I really recommend this video. He took Tramadol for exactly 5 days and then stopped. He's a former trauma surgery nurse and has a lot of experience administering opioids. Most revealing he was just as surprised as anyone else that this worked, though only to mask the symptoms of withdrawal. There was zero high.
 
darvocet21 said:
I really recommend this video. He took Tramadol for exactly 5 days and then stopped. He's a former trauma surgery nurse and has a lot of experience administering opioids. Most revealing he was just as surprised as anyone else that this worked, though only to mask the symptoms of withdrawal. There was zero high.
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Oh well if it’s only 5 days then I wouldn’t be worried but I am a bit skeptical about his claims.
 
I don't personally like tramadol.

If you're gonna do it (I agree you shouldn't) wait until the speed is gone and no more than 300mg. Preferably with a long lasting benzo like diazepam
 
MsDiz said:
Oh well if it’s only 5 days then I wouldn’t be worried but I am a bit skeptical about his claims.
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I'm glad to hear you're skeptical. As a BL staffer I imagine you've heard the most extraordinary claims made for just about every sort of miracle cure

In the video he was pretty emphatic this was never intended to address street-level addiction, which is kind of a revealing remark given that he had been taking 30 mg oxycodone 4x/day prescribed by his pain specialist. I think most opioid adepts would raise their eyebrows and admit his particular habit rivals some levels of "street-level addiction" ... exactly the type of pejorative term that a nurse or former nurse would use, adding credibility to his claims.

It's a 30 minute video because he can be long-winded but the important parts are covered in the first 15 minutes
 
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