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Opioids Topical Morphine- Does it give you any form of high?

swat150

Greenlighter
Joined
Oct 24, 2008
Messages
4
Our local pharmacy compounded morphine with topical cream. When applied to the skin, does any of the morphine make it into the bloodstream to cause the normal side effects (highs) or oral morphine? Thanks for any information, it appears topical morphine is yet to be widely used.
 
Most drugs have a HORRIBLE transdermal bioavailability...the exception being fentanyl which does best with transdermal/transcutaneous at 92% next to IV...most everything else is around 15%...
 
Most drugs have a HORRIBLE transdermal bioavailability...the exception being fentanyl which does best with transdermal/transcutaneous at 92% next to IV...most everything else is around 15%...

I just read a study from a university in Sweden. Appears the Morphine HCL trans-dermal bio availability is 75 %. Interesting.
 
I was wrong...thank you for pointing that out...wasn't sure on the BA of morphine itself, but most of the others are HORRIBLE transdermal...buprenorphine being one of them (which is 15% )...perhaps it has to do with the delivery method as well, as when I asked about making a morphine cream, I was told by sekio that TD was a horrible RoA...

it might also have to do with the fact that it's the HCl salt as opposed to the SO4 salt...I don't think they use the HCl salt at all in the US...unless they're using them for the proposed morphine patches that MIGHT hit the shelves...
 
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