Misc Tolerance to sedating effects of anti-psychotics?

[Sweet P]

Has anybody noticed this? I was first prescribed 25mg's Seroquel a night to sleep, and it worked wonders. But eventually that no longer affected me and I needed 50mg's, and then 100mg's. Now I've reached the point that I can take 5mg's of Haldol (haloperidol) during the day and still remain awake and alert. What gives? I didn't think you could get tolerant to anti-psychs - typical or atypical. And I know my meth abuse isn't affecting it, cos the same thing happens on days that I'm not using.

 

[alphabetalactone]

Yes this happened to me with olanzepine, tolerance happens with all drugs. However one night I decided to take 40mg of olanzepine and I slept for 21 hours!

 

[Mr Blonde]

I developed a brief tolerance to trifluoperazine whilst I was using it for sleep. I wasn't using it for anti-psychotic purposes though so no idea if a tolerance to those effects can develop.

On a side-note, don't ever try to overdose on that shit. The akathisia afterwards is unbearable.

OD sure has changed since I was last here...

 

[thelung]

Eventually your body just adjusts to it so it won't make you drowsy during the daytime

 

[monstanoodle]

You will get a tolerance to any drug that has a sedative effect. The thing is with Antipsychotics is that increasing the dose is sometimes a dangerous thing to do (as Mr. Blonde has pointed out).

p.s. Welcome back Blondey Nice to see you return. Where've you been?