Since it appears as though you may know something about the pharmacology of imidazoline receptors, would you be so kind as to enlighten me more in depth on them and their subtypes? (by more in depth, don't worry about 'too much', just think 'this is a guy who if he sees an all-you-can-eat buffet who's special of the day is 'pharmacology data with a side dish of neurophysiology, sprinkled with a psychiatry dressing for extra flavor, he is going to complain to the chef if they object to taking 'all you can eat' literally to the point where one ends up first biting off several digits belonging to the first complainant, followed by walking out, chewing on a table-leg and muttering things about 'lying greedy bastards' when kicked out of the restaurant for eating too much like a greedy little piggie(hating sonofabitch
)
I've long been interested in knowing more in depth about imidazoline receptors.
Not a bad idea regarding the clonidine/tizanidine mix. To help taper the clonidine, as well as have it stabilize and be able to drop real gradually, then you could start using clonidine transdermal patches, which can be cut, can't they? without insides coming, well, outside.
The idea being to bit by bit, after (with initially using tablets also for the switchover, because transdermal patches can be a bit of a pain in the bollocks sometimes, for things like not sticking properly, coming off and being impossible to reapply, as well as for the first one used, there being a pretty damn significant time between applying a patch and the active drug being released into the body in sufficient concentrations to exert the proper effect.) cut them down in size, and taper off if you have to.
And yeah your doctor is a stupid cock-gargling jizm-stain on the toilet bowl of a greasy, stinking cheap ass dive bar in hell where the beer is utterly shit even before it got watered down. She needs to be cut into lots of little pieces, then the pieces lined up and shot at dawn. With a firework inserted into whatever piece happens to have the anus attached. Sheesh! what a goddamned puppyfucking sphincter-goblin. Sounds like she could guillotine herself, and superglue a pumpkin to the top of her spinal column and not only still manage to function but actually gain several tens of IQ points. Even a rotten pumpkin would be an improvement. And at least then people could do what needs to be done with that doctor and shoot it to pieces with gauss pistol/rifle/railgun rounds, airguns and zap it with microwaves coupled to a waveguide and capacitor bank. Maybe broil her carved out jack-o-lantern eyeballs with the occasional improvised flamethrower whilst screaming the words 'stupid' 'bitch' and 'fucking', not necessarily however, in that specific order.
Also, I could see there not needing to be another receptor type than alpha2 and its subtypes and imidazoline receptor types for the ADD meds effect. Noradrenaline can prime us for focusing, and too little can make it difficult, (clonidine is used in research into learning, memory, LTP etc and nootropic drugs for testing animal reactions, because it can in sufficient doses be amnestic.)
And of course WAY too much nor/adrenergic neurotransmission is well known for giving the subject 'tunnel vision', it is afterall, key to the fight or flight response. You don't need to remember when a man-eating tiger is chasing after you fixing to crack open your skull and use its rough feline tongue to rasp off the layers of your cerebral cortex cell layer by cell layer, like a blood-squirting lollypop. You don't need the details, you need to realize 'its going to fucking eat me, can I kill it, y/n? if 'no' then 'runthefuckaway and throw old people at it to slow it down' My guess is there is a quite finely tuned balance in dosing clonidine etc. for ADD, where too much, is amnestic and sedative whereas too little is either useless or finds another way to start causing trouble such as binding and activating autoreceptor just slightly enough to make concentration shittier and the subject more likely to start running round the classroom bellowing xmas carols which they've changed every instance of the words 'christmas' 'jesus' and 'manger' to 'paedophile' 'naked scrotum' and 'there is just enough room left up in my bum' whilst squealing in the ears of their classmates. Or running in and out of the dorm blocks all fucking night long waking people by shouting in their face whilst they slept until someone ends up pinning them to the wall and beating them black and blue
(yeah, I had some little shit ADHD kids alright, in my school, if it wasn't obvious
)
Anyhow the imidazoline receptors, some of them at least, do look interesting. Anything you'd recommend as a primer? particularly on the brain type, I2 IIRC.
