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Time = Less Tolerance?Why

^^ Huh? In comparison to receptor saturation? Thats in the scale of microseconds, versus 10 minutes for downregulation.

Meanwhile Vaya, there are many studies that claim to have shown that THC is neurotoxic

I agree Blowmonkey, there should be more studies, using slightly more reasonable doses, but looking on longer time scales. Especailly with monkeys. I'm surprised NIDA or the DEA hasn't commisioned the study to be honest.
 
As these people are discussing the chemical part of it, I know for a fact it does lower your tolerance greatly. When I got suspended from school for marijuana a few years ago, I had to go to court and all that. I was put on probation just for 6 months since I wrote a big essay to the Judge about marijuana and the negative effects. Then, once the Judge talked to me, he decreased my probation time.

I couldn't smoke for those 6 months and it sucked. But once the months were over and I smoked for the first time in 6 months, I got fried easily.
 
BilZ0r said:

Meanwhile Vaya, there are many studies that claim to have shown that THC is neurotoxic
Click to expand...

I'll take this as an opportunity to learn, then. Could you provide one or two for a reference point? Thanks!
 
I wrote a review article on the subject, which you can read here:
http://bilz0r.orcon.net.nz/Are Cannabinoids Neurotoxic-12.doc

most of the evidence that shows neurotoxicity is in the 2nd section "Neuronal Morphology".

Because of the word limit I set myself, I had to leave out the in vitro evidence, which shows that THC at concentrations above around 1-10µM kills neurons preety quick, the seminal article in that line, chan et al., 1998, can be found here http://www.ncbi.nlm.nih.gov/entrez/...ve&db=pubmed&dopt=Abstract&list_uids=9651215. That has been repeated numerous times now.

Although that concentration is around 10-times higher than found in recreational users, the chemicals responsible for the toxicity shown by chan et al., (prostaglandins), seem to be released in humans at recreational doses.
 
^^^Interesting article, I hadnt seen it before. In any case, if prostaglandins have been shown to induce hippocampal neuronal toxicity when induced by THC, then we might need to be worried about hallucinogens, too, because they also seem to activate PLA2 and, in addition, cause upregulation of neuronal cylcooxygenase-2, which makes prostaglandins, if I remember correctly, and downregulate the neurotrophic factor BDNF.
 
Yeah, I thought that when I wrote that too. Though I haven't heard about that COX stuff. Though I saw that DOI induced c-fos expression was dependent on COX.
 
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