Tianeptine - Impressive!

[trocious]

I'm surprised this hasn't gotten more attention! Especially with the recent study published stating that it is a full opioid agonist.(Gassaway, MM; Rives, MLL; Kruegel, AC; Javitch, JA; Sames, D (July 2014). "The atypical antidepressant and neurorestorative agent tianeptine is a μ-opioid receptor agonist.". Translational Psychiatry 4 (7). doi:10.1038/tp.2014.30. PMID 25026323.)

I've used it orally in the past, and was generally impressed by its effects. Actually, before that study was published I was shocked by how a moderately high dosage (~100-150 mg P.O.) had such a striking similarity to my previous opioid experiences.

Having the opportunity to sample a >98% pure salt form of tianeptine, I can say that IV is an incredibly powerful and similar experience to many other intravenously dosed opioids.


I'm sure there are drawbacks, but for someone with little opioid tolerance wishing to indulge in the pleasures of that itchy, comfortable blanket, tianeptine fits the bill.

I can't be the only one doing this! Anyone else care to share their experiences? Any tips for doing this the safest way possible? I've found using plenty of water to be helpful in preventing that "sticky shots" people have talked about.

 

[Bocgam]

I was also very surprised at this finding. I've recently used tianeptine to mitigate my minor opiate withdrawals.

Of course, I take breaks and endure my withdrawals to keep my tolerance manageable. Now that I know that tianeptine in fact is an opiate agonist, I may not use it on "off days."

One final complication: tianeptine apparently helps attenuate morphine tolerance when co-administered with that morphine (http://www.ncbi.nlm.nih.gov/pubmed/20679893). Isn't that unusual? An opiate agonist that mitigates its own withdrawals? What the heck?