punkftl
Bluelighter
johnnyb420 said:i hope you were kidding about taking all seven of your carry home doses having to wait a whole week to get your next dose would suck to say the least thats if you made it thru 1190mg of methadone
in my experiance, the cimetidine does not make the high any better just a bit longer as cimetidine competes for the same enzymes that metabolize opioids ,diphenhydramine helps make the high a little less itchy and more noddy if that is a word . i also have had luck with quinine,for both making it stronger and longer .![:\](https://bluelight.org/xf/BL_Images/Orig_Emoji/wrygrin.gif "wry grin :\")
be careful with vitamin supplements as some can burn thru your dose at a faster rate and precipitate withdrawal.
MONITOR CLOSELY: Methadone may cause dose-related prolongation of the QT interval. Coadministration with other agents that can prolong the QT interval may result in elevated risk of ventricular arrhythmias, including ventricular tachycardia and torsade de pointes, because of additive arrhythmogenic potential related to their effects on cardiac conduction. High dosages of methadone alone have been associated with QT interval prolongation and torsade de pointes. In a retrospective study of 17 methadone-treated patients who developed torsade de pointes, the mean daily dose was approximately 400 mg (range 65 to 1000 mg) and the mean corrected QT (QTc) interval on presentation was 615 msec. The daily methadone dose correlated positively with the QTc interval. Fourteen patients had at least one predisposing risk factor for arrhythmia (hypokalemia, hypomagnesemia, concomitant use of a medication known to prolong the QT interval or inhibit the metabolism of methadone, and structural heart disease), but these were not predictive of QTc interval. It is not known if any of the patients had congenital long QT syndrome. MANAGEMENT: Caution is recommended when methadone is administered concomitantly with drugs that prolong the QT interval, particularly in the setting of chronic pain management or methadone maintenance for opioid dependency where high dosages may be employed, or if administered to patients with underlying risk factors. Patients should be advised to seek medical attention if they experience symptoms that could indicate the occurrence of torsade de pointes such as dizziness, palpitations, or syncope. If taking drugs that also cause central nervous system and/or hypotensive effects (e.g., psychotropic drugs like tricyclic antidepressants, phenothiazines, and neuroleptics), patients should be made aware of the possibility of additive effects with methadone and counseled to avoid activities requiring mental alertness until they know how these agents affect them.
and I totally volunteer myself! lol...in anycase I have been taking antioxidants the past few months and trying to get back in the gym routine. I was using an expensive brand that was 'supposed to be' the best. Well one day they were out so i bought some cheap stuff called, 'Protegra' and it just soo happens that I JUST came from the gym so my ankle, the reason I get my scripts, was throbbing and I took my medication(and maybe a few mg more
... ) while simultaneously taking one protegra antioxidant. Now Ive been using pain killers for years, and I had my year of 8-10 lorcets 3 times a day, and the on again off again withdrawals and when i took a pain killer, it was for the buzz only.....well with severe will power, I only take what I am prescribed now, and that is all. It took alot of work to get there and im not going to f*ck it up by that 1-2 hr AMAZING buzz at the movies. MY current dose is 100mg Morph Sulfate PO 3x daily and breakthrough pain im armed with 30mg instant MS every 6 hrs or prn(as needed) and sometimes prn calls for me to take two if im in bad shape and even then I can barely feel that I took it, and a very very slight euphoria for a bit, kind of what you get when all you have left are Tylenol 3's after your perc 10 script is gone. In anycase if that gives me only a slight Euphoria then i cant imagine what I would need to get floored like I used to. Well that day i combined my daily meds and that new antioxidant....was like a blast from the past....all of a sudden out came the droopy eyelids and behind them, the red eyes. Talking to everyone like we were college room mates and Euphoria was just like I remembered, but ive been taking this same dose for a YEAR! How could I get high off of this when the last 364 days just helped with the pain? So I broke my 'not to take pills untill high' rule, and did some experimentation to see if I was on to something. 
I find that tramadol mixes with subutex for some reason but my guess is im not the only one and Ill stop beating the poor dead horse. Enjoy your benny's but dont eat too many or youll be delirious. 
