• Welcome Guest

    Forum Guidelines Bluelight Rules
    Fun 💃 Threads Overdosed? Click
    D R U G   C U L T U R E

⭐️ Social ⭐️ The Stimulant Social Parlor. A place to talk about nearly anything. If you don't break forum and site rules, I'll allow it! Potential triggers inside!

mtu mwendawazimu said:
From my little bit of understanding, the middle of the country has good shit, next comes California, maybe Texas, and then the east coast is shooting MSM.

I did an acetone wash on a couple batches, most came back, still trash.

So maybe @thegreenhand is on to something. Or, acetone wash is old news.
Click to expand...
Ah, ok. Where are you located?
 
G_Chem said:
How can neurogenesis and neurotoxicity coexist?

-GC
Click to expand...
I'll be honest, I don't quite understand it, and perhaps I'm misguided, but it would appear that what is damaging to dopaminergic striatal neurons isn't necessarily damaging to hippocampal dentate granule cell neurons? I'm not really sure, to be honest, perhaps I shouldn't have made that comment. I'm not a neuroscientist.
 
acklac7 said:
I'll be honest, I don't quite understand it, and perhaps I'm misguided, but it would appear that what is damaging to dopaminergic striatal neurons isn't necessarily damaging to hippocampal dentate granule cell neurons? I'm not really sure, to be honest, perhaps I shouldn't have made that comment. I'm not a neuroscientist.
Click to expand...
Maybe educate yourself and then educate us. Lots of us are doing potentially neurotoxic activities. Something that allows the abatement or easing of that it is certain to be potentially helpful to some people.
 
acklac7 said:
I'll be honest, I don't quite understand it, and perhaps I'm misguided, but it would appear that what is damaging to dopaminergic striatal neurons isn't necessarily damaging to hippocampal dentate granule cell neurons? I'm not really sure, to be honest, perhaps I shouldn't have made that comment. I'm not a neuroscientist.
Click to expand...

That doesn’t sound completely far fetched. This is a topic I too would like to know more about so if you ever get the time to do the research I’d be curious to see as well.

-GC
 
4shitzngigs said:
i have a weird problem. I do heroin regularly and on occasion when i do meth as well my burps turn putrid for at least the day if not 2. And it makes me burp these horrible burps frequently with the bubble guts. This happens almost EVERY TIME i do meth along with the h i usually do. Anyone else have this happen or have any suggestions?
Click to expand...
OMG I've been having this same exact problem. It's crazy. Thought I was the only one.
 
G_Chem said:
That doesn’t sound completely far fetched. This is a topic I too would like to know more about so if you ever get the time to do the research I’d be curious to see as well.

-GC
Click to expand...
I've done quite a bit of research, and from the studies I've read meth stimulates neurogenesis in doses ranging from 50mg - 200mg (for a 220lb individual). It's actually quite interesting because I think most all users will agree that 50mg (or more) is NOT a "low dose" (for someone with zero tolerance) and therefore must be neurotoxic / non-neurogenic. However, from a scientific standpoint a "low dose" is commonly referenced as 50mg - 200mg (for a 220lb person). High/Neurotoxic doses are almost solely cited as doses in excess of 500mg (for a 220lb person). It gets even more interesting because 95% of the studies out there that reference meth neurotoxicity (or even meth in general!) start with a dose of 500mg, and go up from there (up to 3000mg+! LOL!) Like, do you think a 3-GRAM dose is neurotoxic? Do you think!? And what user uses 500mg in a dose!? Maybe someone who has been using for a decade? (Although I guess your typical meth addict will commonly use 500mg-1000mg+ in a day, but not a dose).

Take for example this study from 2016: Long-Term Treatment with Low Doses of Methamphetamine Promotes Neuronal Differentiation and Strengthens Long-Term Potentiation of Glutamatergic Synapses onto Dentate Granule Neurons, which studies the neurogenic effects of meth. The dosages involved in this study? 200mg/dose (for a 220lb man). That's what they're citing as a "low dose". I personally find the last paragraph of the study to be fascinating:
In conclusion, the present work shows that long-term administration with a low dose of METH promoted the differentiation of immature neurons and enhanced LTP in differentiating and mature DGCs. It will be fundamental to understand how prolonged use of METH will convert such “positive” effects on neurogenesis and synaptic plasticity into the well known dysfunctional effects that strongly impair cognitive performance in METH-addicted subjects.
Click to expand...
There's something we're missing. At certain dosages, meth is apparently able to cause positive neurogenic activity which somehow (possibly) leads to negative/damaging/dysfunctional cognitive activity down the road (with prolonged use). This is where my "Neurogenic and Neurotoxic" comment comes from - although once again I'm not sure if that comment is accurate.

And then you have this (rather interesting) study from just last year Methamphetamine and Modulation Functionality of the Prelimbic Cortex for Developing a Possible Treatment of Alzheimer’s Disease in an Animal Model which cites a "low dose" as 100mg/dose (for a 220lb individual). Based on the study, a 100mg dose provides for significant enhancements in neurogenesis/neural activity/synaptic plasticity/cognition. The conclusion reads as follows:
Using a low dose of 1 mg/kg MAMPH with three continuous administrations in the present study produced CTA conditioned learning, increases in plasma corticosterone levels, and enhancements in neural activity in c-Fos expression, and neural plasticity in p-ERK expression in the cognitive function areas (the mPFC, e.g., Cg1, PrL, and IL), the affected brain areas (the rewarding NAc and rewarding and aversive BLA), and the spatial learning and memory brain areas (the hippocampus’ CA3 and DG). Additionally, the excitation of the PrL neurons induced more enhancements for neural activity and neural plasticity in the PrL and IL of the mPFC’s subareas, indicating that a low dose of MAMPH in conjunction with the excitation of PrL neurons might lead to a higher level of neural activity and plasticity than a single MAMPH administration in ameliorating cognitive functions. Therefore, low doses of MAMPH and the modulation of PrL neurons might provide a possible treatment for certain symptoms of AD.
Click to expand...
Finally, you have this study (which I'm sure everyone on here is familiar with) the one I've blasted on here over and over again (my apologies) The neuroprotective potential of low-dose methamphetamine in preclinical models of stroke and traumatic brain injury (RIP Dr. Paulsen) The results of which actually resulted in a Patent for Reducing Brain Cell Damage or Death. This study looks at dosages of 50mg/dose (for a 220lb individual) and concludes that:
In all of our studies using low dose methamphetamine we have not found any evidence of neuropathology caused by the drug treatment. To the contrary, we have observed a reduction in neuronal loss, apoptotic cell death, and neuromotor/cognitive impairment after acute brain injury. In light of the fact that low dose methamphetamine is FDA approved for use in juveniles and adults, we see no valid reason why it cannot be utilized in human clinical trials for stroke and TBI. We propose that low dose methamphetamine has significant potential as a neuroprotective agent when the dosing is kept within safe, previously established guidelines.
Click to expand...
Basically, at the end of the day, what we (as users) consider a "low dose" (5-25mg for someone with no tolerance) isn't necessarily what the scientific community considers a low dose. Once again, scientifically speaking a low dose is referred to as 50mg-200mg, but would I recommend someone with zero tolerance to dose anything more than 50mg? Hell no. Do I consider 100mg, 200mg to be a low dose? Hell no! But, according to the research I've done (and I've done a lot...), and unless I'm missing something, a low (neurogenic) dose is commonly referenced as anywhere from 50mg-200mg (for a 220lb individual). Which I think we can all agree is rather surprising.

Now, am I saying (low-dose) meth is harmless and to go out and use (low-dose) meth? No. Meth is definitely dangerous as hell, even in low doses. I never used more than 200mg/day (a dose considered to be "low" by the scientific community) and I ended up going batshit crazy on it after several years. But based on my research it's not necessarily as wholly-damaging to all parts of the brain as the general public has been lead to believe.

There's something weird going on with meth, in certain dosages (and in certain pathways) it has these weird (extremely) beneficial effects on certain parts of the brain that down the road, with repeated use, potentially directly (or indirectly) translate into extremely negative effects on others. We're in the process of trying to figure out the exact how and why that is, but we're still a long ways out from nailing it down cold.

While we've learned a metric fuck-ton about how exactly (meth) impacts the brain the past 20 years, there's a lot we don't quite understand, and even more we don't quite understand about the brain in general. What would be ideal is if we could somehow "bio-engineer" meth (“Bio-Meth” @Atomic_Decay 😉) such that we could isolate it's beneficial properties/pathways from it's detrimental properties/pathways and create some sort of new drug/medication. I think that's where a lot of this research is headed. Some of these studies as of late are downright WILD, primarily these two which were published just last year:

Methamphetamine and Modulation Functionality of the Prelimbic Cortex for Developing a Possible Treatment of Alzheimer’s Disease in an Animal Model

Potential Neuroprotective Mechanisms of Methamphetamine Treatment in Traumatic Brain Injury Defined by Large-Scale IonStar-Based Quantitative Proteomics
 
Last edited:
Koka-kola said:
I've researched on various sites online & have found conflicting results. I have a vapresso stick vape & was wondering if it's possible or effective to put some dope in vape juice and vaporize it that way. & If I could what's the proper ratio of dope to juice?
Click to expand...
So I knew it was possible so I went to the lab and started trying shit out. Long story short you can even do this in an oil pipe. Get a big one. Take a gram or two throw it in there and take your favorite vape juice, I’ve tried it with all types. Just enough to liquidize it. Take the torch and slowly heat it until everything is dissolved. Let it cool and if it doesn’t rock back up it’s good. The stronger you want it less liquid on it. But it has to cool and stay a liquid. You can play with untill you got it down. Add more liquid or ice. Now the carts. Some cheap ass one will work a few times then they burn out. Good one will last but don’t make a bunch up and let them sit unless they are good carts, they will ruin all the carts. We’ll ruin them to use. I learned that the hard way. But I got it now where I can be anywhere and smoke that shit and nobody has a clue. Can even sell them for 100 a piece… so I stamp that shit works. Heat extract pour it in a dropper, fill and go but let it cool all the way to know if it will stay a liquid…
 
acklac7 said:
And they're not dopaminergic neurons, they're dentate granule cell neurons located in the dentate gyrus / hippocampus which are responsible for learning/memory/cognition etc. They're not specific to any certain ROA from the literature I've read. As for the dosages involved, it's actually more than you would think: Neurogenic doses range from 5-200mg. Yes, you read that right, up to 200mg. Now, just because a dose is neurogenic doesn't mean it's non-neurotoxic! To avoid neurotoxicity I would stay below 100mg (more like below 50mg).

Be careful @Hugs For Drugs, you mentioned previous bouts of psychosis, and psychosis isn't anything to play with. I wouldn't touch meth at all if I were you. Psychosis can get real problematic real fast. There are plenty of other ways to stimulate neurogenesis: vigorous exercise, soaking for prolonged periods in a hot bath, eating certain foods, learning challenging concepts. All will help stimulate neurogenesis. With your prior history of psychosis I'd leave meth alone and focus on something less dangerous in your neurogenic quests.

A few good read(s) on neurogenesis:
https://www.verywellmind.com/adult-neurogenesis-can-we-grow-new-brain-cells-2794885 https://selfhacked.com/blog/ways-increase-neurogenesis/
Click to expand...
Don't worry, I've been through many psysis's when I was younger, now they make me laugh and I don't pay many attention to them, because they will be there no matter what 😂
 
Yep, sure can. Just load it up, I use non nicotine and even no Vape shit at all sometimes. Just down (fent based) and side. No one has ever noticed. If u dont do down, just gib works fine. First vape I bought had half ball meth in it. Best $15 I ever spent. 🙃
 
tweek carts

are those on the dark web?

if not, that's what i would do if i were to do something like that :cool:
 
arrall said:
NSADD -> TDS
NSADD is generally for discussions specifically related to North and South America. People seeking support will generally get more responses by posting in 'The Dark Side'.

@acklac7, I think that n-iso is quite uncommon and largely a myth in most places. @SchoolofShardKnocks can clarify this for us far better than I can.
Click to expand...

SchoolofShardKnocks said:
N- Iso is such a myth it's not even funny.

It has zero psychotropic effects whatsoever. That means that there is no rush, no high, nothing. It's also incredibly easy to identify. You'd get some tachycardia and probably very sick to your stomach if you actually did get it (you probably didn't))
Click to expand...
So, I actually got N-Iso of the Darknet. It was my first time buying meth, and I went with the cheapest vendor available without doing much research (big mistake). The first thing I noticed was that it crushed up really easily, like dissolved into powder instantly. So I did a fat line (which burnt like hell) waited about 10-20 minutes and didn't feel much of anything, so I did another fat line. Got some mild stimulation, although it wasn't anything even approaching the stimulation effects of Adderall, let alone meth (trust me, I know my meth, well now I do at least). I went on snorting lines all night and into the next morning with little-to-no effect. And then came about noon and I felt like I was going to die. I wasn't even stimulated, I just felt like I was going to die. My heart felt like it was going to cut-out at any moment, I started getting these "jolting" sensations all throughout my body, I just felt like my heart was failing and I was going to die at any moment. I wasn't even high. I nearly collapsed at my buddy's house, apologized profusely, and said I had to go home immediately. Got home and threw the junk out, feeling like I was going to die at any moment, barely able to breathe just sick and shaking, on the verge of collapse. Never in my life have I felt closer to death. Shit scared me so bad I didn't touch meth for another year....
 
You must log in or register to reply here.
Top