helium-4
Bluelight Crew
I wasn't trying to keep this negative energy flowing, my last post was to try and promote an interesting conversation. I'm not sure why that is a problem. I'm not being negative in anyway, nor at all trying to start an argument. I never even thought we were arguing in the first place. From my perspective not a single one of my posts had that intent.
I have no problem with you giving me suggestions, I just rather have a intelligent conversation about it. Having someone tell me they think I should lower my dosage with out discussing it with me really isn't a very productive response, so that is part of the reason I want to try and have better conversation. Quickly on your statement about other treatments, assumingly you meant both non-pharmacological as well as pharmacology, I mentioned in at least one post, maybe two if I recall correct, going over this. I originally started out rally focusing on non-pharmacological pursuits after seeing a doctor for the first time. I made sure to cut back on the alcohol which was a little harder right since I moved to another state after leaving college, but at this point I don't drink but say max once a month (1 beer or wine). It wasn't like I was drinking daily or even more than 2 times a week, but that did become the first to go. I always try to walk at least a mile 2 hours before bed, whether or not I had a work out that day, then return home for a quick shower rinse to a warm bath. In the bath I try to message my legs to see if that can add some relief. I will admit I struggled a little bit with nicotine, but through out the last 3 months I've only bought 3 packs total. Still more than I should, but For the most part cigs and alcohol are not in my life anymore. I also try to take supplements, notably Mg2+ Citrate, but also the standard multi vit, coq12, b-complex, baby asprin, fishoil, and a protien shake. Living at home currently also helps increase my fruit and veggie consumption. A lot of my meals are actually wegiht watchers as my dad has been been following the program. I know a lot of families miss out on having dinner together, and eve though my relationship isn't that great with my parents, I've always enjoyed eating with each other,
Anyway, no one of those activities were doing very much. I was really hoping that running during the day and having a nice our walk at night would make a noticeable difference, but to be 100% honest it didn't. I've also had countless blood tests done, at my PCP, my hematologist, and gastroenterologist. I've seen my minor liver abnormalities on two tests (months a part), with clean follow ups. There was one interesting thing about about a blood test, that a first could have been a sign of a actually medial problem that could be linked my RKS, but with some genetic testing from my hematologist (along with a bunch of other tests I don't know). They saw an abnormal Fe storage capacity that could have indicated hemochromatosis. Luckily like I said that genetic test came back negative along with all of his other tests runs.
After trying to go the non-pharmacological route (not that I stopped anything), I went through two different dopamine agonists. This seemed like it could have been a very good option for me. I'm ADHD, have had symptoms of RLS/PMLS as a kid, but didn't think much of it. Thought it was just my ADHD. Now there are studies out there saying that there could be a legit tie between individuals with different variants and severity of ADHD or tic disorders as, and sleep disorders. Both individuals with ADHD and RLS/PLMS are theorized to have a dysfunctional dopaminergic neurons in specific locations within the brain. These locations have some influence over movement as one major properties, but of course many, many others (don't feel like writing paragraphs and paragraphs more). I will say though, these dopaminergic neurons are also seen to interactive with and are innervated with GABAergic as well as opioidergic receptors. There are a few theories that support where some of the uncomfortable sensations that can be considered a form of pain (don't remember the specific names of them on the top of my head) have neurological problems related to these dopaminergic, opioidergic, and GABAergic (thought i think this is way less important in neuro pain). I'm super tired right now and spent over an our trying to write out a well written discription of one of the possible pathologies involving hypofunctioning dopaminergic receptors, reduced amount of TH, and low and reduced amounts of endorphins all with in specific locations. The involvement of endorphins, or lack there of essentially produces a hyperanalgesic state, along with the hyper activity of the limbs through I believe small amounts of a d2 receptors within the central parts of the brain, playing a role as an inhibitory receptor with movement one of the altercation in movement as a biological response.
Anyway since I spent to long researching one real complex aspect of the pains assocaitied with RLS, I'll just quickly sum everything up.
The dopamine agonists, cause me a lot of problems, which required me to immeditelys discontinue their use. Honestly I wouldn't have minded ropinirole working because I found it to be a good anti-depressant, helped with anhedonia, vivid dreams, amazing for social anxiety, but just OK for RLS. So the side -effects sucks as well as the only mild effeiency, not to mention the augmentation that is seen with dopamine agonists.
After that I triend clonazepam, which I still have. That is really just to allow me to fall asleep and stay asleep (so the PLMS doesn't wake me). I just don't like clonazepam very much. Especially since it means another psychical addiction. I rather just have an opioid addiction personally. I then wanted to try and find something for my RLS. I tried gabapentin, but it worked for social anxiety and mood swings, but not any sort of RLS symptoms. I then went and tried Tramadol. I'm sad it didn't work. Unfortunately for me it is super stimulant, makes it pretty uncomfortable and don't do that much for the RLS symptoms once again. Now I would have been fine if my opioid tolerance still existed at a reasonable level. My next option was to go with a more potent opioid. I chose methadone because I know I'm a drug addict. I don't want oxy, and know I would have abused alot of it, especially since life has been fucking with me as of late. I could also get into the whole other pharmacological properties with methadone that make it appealing, the low abuse potential that exists on it, and the rare amount of side-effects that happen. Yes it can be dangerous, yes there are reports of some people dying because of heart trouble, but those individuals already had some heart problems in the first place. When they scripted me the done, they gave me a note to go to the hospital.
Anyway its late, and I got work tomorrow. I didn't mean to spend so much time reading for what was supposed to be a small post.
I have no problem with you giving me suggestions, I just rather have a intelligent conversation about it. Having someone tell me they think I should lower my dosage with out discussing it with me really isn't a very productive response, so that is part of the reason I want to try and have better conversation. Quickly on your statement about other treatments, assumingly you meant both non-pharmacological as well as pharmacology, I mentioned in at least one post, maybe two if I recall correct, going over this. I originally started out rally focusing on non-pharmacological pursuits after seeing a doctor for the first time. I made sure to cut back on the alcohol which was a little harder right since I moved to another state after leaving college, but at this point I don't drink but say max once a month (1 beer or wine). It wasn't like I was drinking daily or even more than 2 times a week, but that did become the first to go. I always try to walk at least a mile 2 hours before bed, whether or not I had a work out that day, then return home for a quick shower rinse to a warm bath. In the bath I try to message my legs to see if that can add some relief. I will admit I struggled a little bit with nicotine, but through out the last 3 months I've only bought 3 packs total. Still more than I should, but For the most part cigs and alcohol are not in my life anymore. I also try to take supplements, notably Mg2+ Citrate, but also the standard multi vit, coq12, b-complex, baby asprin, fishoil, and a protien shake. Living at home currently also helps increase my fruit and veggie consumption. A lot of my meals are actually wegiht watchers as my dad has been been following the program. I know a lot of families miss out on having dinner together, and eve though my relationship isn't that great with my parents, I've always enjoyed eating with each other,
Anyway, no one of those activities were doing very much. I was really hoping that running during the day and having a nice our walk at night would make a noticeable difference, but to be 100% honest it didn't. I've also had countless blood tests done, at my PCP, my hematologist, and gastroenterologist. I've seen my minor liver abnormalities on two tests (months a part), with clean follow ups. There was one interesting thing about about a blood test, that a first could have been a sign of a actually medial problem that could be linked my RKS, but with some genetic testing from my hematologist (along with a bunch of other tests I don't know). They saw an abnormal Fe storage capacity that could have indicated hemochromatosis. Luckily like I said that genetic test came back negative along with all of his other tests runs.
After trying to go the non-pharmacological route (not that I stopped anything), I went through two different dopamine agonists. This seemed like it could have been a very good option for me. I'm ADHD, have had symptoms of RLS/PMLS as a kid, but didn't think much of it. Thought it was just my ADHD. Now there are studies out there saying that there could be a legit tie between individuals with different variants and severity of ADHD or tic disorders as, and sleep disorders. Both individuals with ADHD and RLS/PLMS are theorized to have a dysfunctional dopaminergic neurons in specific locations within the brain. These locations have some influence over movement as one major properties, but of course many, many others (don't feel like writing paragraphs and paragraphs more). I will say though, these dopaminergic neurons are also seen to interactive with and are innervated with GABAergic as well as opioidergic receptors. There are a few theories that support where some of the uncomfortable sensations that can be considered a form of pain (don't remember the specific names of them on the top of my head) have neurological problems related to these dopaminergic, opioidergic, and GABAergic (thought i think this is way less important in neuro pain). I'm super tired right now and spent over an our trying to write out a well written discription of one of the possible pathologies involving hypofunctioning dopaminergic receptors, reduced amount of TH, and low and reduced amounts of endorphins all with in specific locations. The involvement of endorphins, or lack there of essentially produces a hyperanalgesic state, along with the hyper activity of the limbs through I believe small amounts of a d2 receptors within the central parts of the brain, playing a role as an inhibitory receptor with movement one of the altercation in movement as a biological response.
Anyway since I spent to long researching one real complex aspect of the pains assocaitied with RLS, I'll just quickly sum everything up.
The dopamine agonists, cause me a lot of problems, which required me to immeditelys discontinue their use. Honestly I wouldn't have minded ropinirole working because I found it to be a good anti-depressant, helped with anhedonia, vivid dreams, amazing for social anxiety, but just OK for RLS. So the side -effects sucks as well as the only mild effeiency, not to mention the augmentation that is seen with dopamine agonists.
After that I triend clonazepam, which I still have. That is really just to allow me to fall asleep and stay asleep (so the PLMS doesn't wake me). I just don't like clonazepam very much. Especially since it means another psychical addiction. I rather just have an opioid addiction personally. I then wanted to try and find something for my RLS. I tried gabapentin, but it worked for social anxiety and mood swings, but not any sort of RLS symptoms. I then went and tried Tramadol. I'm sad it didn't work. Unfortunately for me it is super stimulant, makes it pretty uncomfortable and don't do that much for the RLS symptoms once again. Now I would have been fine if my opioid tolerance still existed at a reasonable level. My next option was to go with a more potent opioid. I chose methadone because I know I'm a drug addict. I don't want oxy, and know I would have abused alot of it, especially since life has been fucking with me as of late. I could also get into the whole other pharmacological properties with methadone that make it appealing, the low abuse potential that exists on it, and the rare amount of side-effects that happen. Yes it can be dangerous, yes there are reports of some people dying because of heart trouble, but those individuals already had some heart problems in the first place. When they scripted me the done, they gave me a note to go to the hospital.
Anyway its late, and I got work tomorrow. I didn't mean to spend so much time reading for what was supposed to be a small post.
