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  • N&PD Moderators: Skorpio | someguyontheinternet

The Neuroscience behind the 5-HT2a receptors.

Hmmm.... Now I'm thinking too hard. I keep connecting beta-arrestin to the RALGDS protein. If only there was one simple way to achieve permanent weight loss and cure diabetes.
 
Beta arrestin is a signaling protein that can bind to GCPRs intracellularly, theoretically this different protein binding causes the overall GCPR to have a slightly different conformation which can enable selective ligand binding

Binding these receptors causes beta arrestin to drive receptor internalization which may take the ligand with it, although I don't know if this would be effective for getting proper concentrations of the drug at the target
 
MedicinalUser247 said:
Oh my god ! Know wonder why weight loss drugs are so expensive. I was looking at some of there chemical structures and there huge !
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Peptide drugs are often made in yeast or e coli, as you can pretty easily put DNA in them and have them turn it into protein.

However, synthetic peptides aren't as horrible (cost or difficulty wise) as you may think, as there are automated systems that "grow" peptides via cycles of different chemical reactions involving compounds that "activate" the terminal carboxyl group to allow for the next amino acid to attach. The downside is that you get lower fidelity after about 20 amino acids, and some secondary structure will fail or misfold (guess how I know that?).
 
Well... I know out of the 500 acids amino acids in nature only 22 appear in lifeforms. As for working on a diabetes or weight loss medication maybe an irreversible form of Insulin or some type of gene therapy might help.
 
What if you substituted MK-801 with Ketamine and then mixed it with something such as Retatrutide ? Do you think that, that would be more tolerable ?
 
I have a question. Do you think there's any possibility that 3,3-Diidolymethane can be made into some sort of psychoactive drug ?
 
MedicinalUser247 said:
I have a question. Do you think there's any possibility that 3,3-Diidolymethane can be made into some sort of psychoactive drug ?
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It looks like it could be an okay lead for a HDAC inhibitor. It certainly wouldn't be easy to make it into a psychadelic if that is what you are asking about.
 
I'm also wondering how you design an Amphetamine that has the dopamine skeletal structure, but is non neurotoxic.
 
Yeah, I figured that one out.

Now I'm just wondering if it's dangerous to design a hallucinogen out of Rasagiline ?
 
One of the things I want to do is come up with a 5ht-2 super agonist so people can trip their brains out. But I don't know if it's possible to design one or what I should be looking at to make the design.
 
The percentage of activation is really just a comparison between the degree of activity when compared to the endogenous ligand, serotonin in this case. So when you say it activates a receptor at 100% it works as well as serotonin for eliciting a cellular response
 
Oh... I was just tying to figure out the whole pie chart when I use the Swiss Target Prediction. I've been trying to get it to hit 100% in that category of the pie chart.
 
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