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The Large and Nifty Not-quite-advanced Drug Chemistry, Pharmacology and More Thread

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Question: what's the pKb of carbonate (the *diprotonated* conjugate base of carbonic acid)? I confess I am in a depressive funk right now and have forgotten how to look up pKb's of conjugate bases of weak diprotic acids.
1st deprotonation:
H2CO3 + H2O ---> HCO3- + H3O+
pKa = 3.88; But because the equilibrium CO2 + H2O -> H2CO3 lies very much on the left side (H2CO3 is unstable!), the first equation and the hydrolysis are usually combined to give a pKa = 6.5

2nd deprotonation:
HCO3- + H2O ---> carbonate + H3O+
pKa = 10.33

The relation between pKa & pKb is as follows:
pka + pkb = 14


Peace! - Murphy
 
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^Thanks. That always confuses me: acids and bases that are prone to decomposition.
 
Extraction of DMT

I thought this was ok because it isn'tabout synthing anything.

In the extraction of DMT, is there anything that you can use other than pure ammonia to do it? I can't seem to find any of the commonly listed strong bases.

Could I use urea? If so, how? Cold I get my own ammonia from urine? How would I purify it? Just some suggestions I got.
 
Ammonia gas can be easily produced from cheap ammonium salts and a suffiently strong base like NaOH or KOH. All OTC. Nonetheless is this not recommended to the layman, due to the hazard potential that this methods brings naturally.

- Murphy
 
I thought this was ok because it isn'tabout synthing anything.

In the extraction of DMT, is there anything that you can use other than pure ammonia to do it? I can't seem to find any of the commonly listed strong bases.

Could I use urea? If so, how? Cold I get my own ammonia from urine? How would I purify it? Just some suggestions I got.

You can use pretty much any base for A/B, and any strong base for STB.

I've had good results with KOH and NaOH. Sodium carbonate I tried a few times and it always gave me emulsions which were a bitch to deal with, so I don't recommend that.

If you have trouble finding bases, you can make wood ash lye: burn some wood, collect the ashes, soak in slowly boiling water - and you have a solution of wood ash lye. It is only useful for A/B though, won't work for STB.


e.- also, what are you using the ammonia for? If it's for purification, don't, the method of ammonia-purification is not recommended - it's a very outdated and inefficient method. Frankly, DMT extracted from MHRB shouldn't require any purification if done right - you should get a totally usable product without purifications or re-x:s.
 
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anyone know of N-Methyl-6-APB

Anyone know whether these would be active/worthwhile

N-Methyl-6-APB
N-Methyl-6-APDB
N-Methyl-IAP
 
Are there oils which sink below water, and not rise above?

I have heard sassafras may be heavier than water and lower instead of rise above the water. Just wanted to see if anyone has some info on that one...

thescientist
 
a) Is it liquid at a temperature range at which water is also liquid?
b) Is it insoluble in water?
c) Is its specific gravity greater than 1?
 
It's all about density, really. Liquids with a larger density than water usually sink to the bottom if they are insoluble in water.
 
Anyone know whether these would be active/worthwhile

N-Methyl-6-APB
N-Methyl-6-APDB
N-Methyl-IAP
While I have no specific info, I find it very unlikely the first two wouldn't be active, and probably worthwhile as well. The third IDK.
 
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