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"The Holy Quadruplty"

Because that's mdma etc.

If the drug was effective its sounds like it would fit in that class. Or in between that and gabapentinoids.
 
Meal Replacement Pills

Each pills contains:

150mg Caffeine
150mg Phenylpiracetam
50mg Bromantane
4mg Rauwolscine
15mg 2FMA
5mg aMT

Do not exceed 2 pills per day. Do not take past 4PM. Cycle 2 weeks on 2 weeks off.
 
Phobos said:
Meal Replacement Pills

Each pills contains:

150mg Caffeine
150mg Phenylpiracetam
50mg Bromantane
4mg Rauwolscine
15mg 2FMA
5mg aMT

Do not exceed 2 pills per day. Do not take past 4PM. Cycle 2 weeks on 2 weeks off.
Click to expand...
Sounds pretty cool, I never heard of some of the ingredients, but I'll look em up now!
 
Twilightex OTC syrup
(Each teaspoon contains)
Chlorpheniramine 2mg
Loperamide 8mg
GABA 200mg
(Alcohol Free)

(The OTC version of the Twilightex I made)
 
A good place to start would be looking at various pharmacophores for each receptor and looking if overlap is possible.

Due to the explosion in research chemicals in these 3 classes, you can examine many scaffolds and look for commonalities between them.

I caution using swisstarget prediction to guide you, as only interactions with the likeliehood bar filled more than 90% will be druglike.

There are many structure activity relationship (sar) studies on agonists of each receptor that have done most of the work, and will tell you motifs necessary for binding each receptor.

I guess a more general thing is to familiarize yourself with Lipinski's rule of 5, which is a heuristic for drugs that actually manage to get into the brain at an appreciable level.

Designing such a drug that you propose is honestly a herculean task. If somebody proposed this as a pHD project, it would be shot down due to unfeasibility to do within a 5-7 year timeline.

May be much easier trying to design molecules where there is already known overlap such as DAT ligands that are also NMDA antagonists.
 
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