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"The Holy Quadruplty"

They say gabapentin doesn't even increase GABA even though it's chemical structure is literally GABA with a little differences. I've even read that Xanax supposedly doesn't even bind to GABA receptors, but also read that it does, same with Gabapentin. I've also read gabapentin binds to GABAt receptors. I'm pretty sure gabapentin does the same thing as Xanax, but in a different way. Do you guys know if gabapentin actually increases GABA at all, and if it really does, or doesn't bind to GABA receptors at all? I've read it makes GABA by releasing other neurotransmitters that eventually make GABA. like serotonin being released to turn into GABA eventually or whatever. I'd think it might do that a little bit, but I think it literally increases GABA directly, and may possibly bind to some type of GABA receptors? What do you guys think about this? I would appreciate any info on it. Also I've been taking gabapentin everyday for the last 5 or 6 days at mgs of 300mgs some of the days, and 600mgs the others, but I took 900mg last night tho, well yesterday threw out the day atleast. I have three 300mg gabapentin left. I took 1 300mg gabapentin this morning to potentiate my other stuff, and for recreational purposes on its own of course. Do you think the 300mgs will do anything at all taking on today, one tomorrow, and one the next day? I really want to make them last, because I'm pretty sure I can't get anymore, that I know of atleast. I really like em too, especially with my other stuff, chlorpheniramine, promethazine, subutex, xanax, and weed.
 
Negentropic said:
There is actually some science behind this concerning psychedelics.

Acute sleep deprivation upregulates 5-HT2a/R receptors.

If you've ever noticed that you feel higher on psychedelics when skipping out on sleep, it's because you actually are.

This should be avoided, though. It led to a psychosis for me. I was very frequently and routinely tripping at night and not sleeping at all until the next night.
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I was wondering if this was a thing or just my imagination. I’ve noticed that when LSD tolerant from a recent trip, dropping acid at the tail end of a subsequent 48 hour meth binge gives a surprisingly solid psychedelic experience for quite a few hours.

Like, I’d estimate the meth/exhaustion factor cuts the tolerance effects by half. It also seems to really level out your comedown and prevent a lot of post-meth brain fog.
 
Merged all of your threads @The Holy Quadruplty

Drop your random queries here please from now on, I definitely already asked you once.

We're happy you're posting but each thought you have doesn't need its own thread, especially considering that they're basically all about similar things. Most of the threads on this subforums first page have been yours.
 
The Holy Quadruplty said:
Chlorpheniramine
Promethazine
Subutex
Xanax

If you never tried this drug cocktail you're missing out big time. There is something different about this combo than other similar drug combos like only promethazine with Subutex and Xanax together even. Hydroxyzine with opanas wouldn't even compare to it. It kinda feels like Ketamine mixed with opanas, xanax, scopolamine, and LSD. Very intensely euphoric especially with weed. You can literally sit there all day long for months straight just staring at the wall, out the window, or anything at all really, and be completely satisfied, content, not bored at all, extreme senses of well being. Very hallucinagenic too with comfortable delerium. It can make things feel really and look really bright and trippy. You have a very intense downer effect not wanting to move, but enough stimulation from the chlorpheniramine and subutex for it to feel extra good when you do move around or get up and do things. I've tried literally almost every drug in so many different combinations, and "The Holy Quadruplty" is definitely the best one IMO atleast. It's even better than heroin with meth or like Percocets with Xanax. Hallucinagenic effects comparable to LSD even with the xanax in the mix which is another distinct effect of this combination. If anyone on here has tried it please lmk what you think!
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Yeah you're not a very serious person when it comes to harm reduction that's fine. Surprised you didn't throw in booze although maybe you did because I didn't read more than the first few sentences
 
The Holy Quadruplty said:
That's exactly what I was thinking, but it definitely says it's a type of alcohol tho. I looked up meprobamate on wiki, and at the bottom it has suggested drugs slash wiki pages, and I clicked on one of them. That's the page I read it on. I'll try to find it again. If I can I'll post it, and or share the link.
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Meprobromate is not an alcohol, but a carbamate.Carbamates are made from a parent alcohol. It is like an ester but has a nitrogen (amide) linkage opposite the oxygen that would be the ester bond. https://en.wikipedia.org/wiki/Carbamate
There is a carbamate form of ethanol called ethyl carbamate. It actually is a stronger sedative than ethanol, but is a fairly nasty carcinogen so is not used (even worse than ethanol itself).
https://en.wikipedia.org/wiki/Ethyl_carbamate

A lot of old sedatives were carbamates, and usually the corresponding alcohol is a sedative too. However carbamates can have other functions, a lot of pesticides are carbamates, and inhibit the enzyme acetylcholinesterase like nerve gas does.

Alcohol just means a compound has a free hydroxyl (OH) group on it. Alcohols are only liquid when low molecular weights. Alcohols can be solid or liquid (adding an alcohol group actually raises the boiling and melting points of compounds. Methane is a gas at room temperature, methanol is a liquid. Same with ethane and ethanol, propane and propanol, and butane and butanol).

Just because something is an alcohol does not mean it will get you drunk.
 
Skorpio said:
Meprobromate is not an alcohol, but a carbamate.Carbamates are made from a parent alcohol. It is like an ester but has a nitrogen (amide) linkage opposite the oxygen that would be the ester bond. https://en.wikipedia.org/wiki/Carbamate
There is a carbamate form of ethanol called ethyl carbamate. It actually is a stronger sedative than ethanol, but is a fairly nasty carcinogen so is not used (even worse than ethanol itself).
https://en.wikipedia.org/wiki/Ethyl_carbamate

A lot of old sedatives were carbamates, and usually the corresponding alcohol is a sedative too. However carbamates can have other functions, a lot of pesticides are carbamates, and inhibit the enzyme acetylcholinesterase like nerve gas does.

Alcohol just means a compound has a free hydroxyl (OH) group on it. Alcohols are only liquid when low molecular weights. Alcohols can be solid or liquid (adding an alcohol group actually raises the boiling and melting points of compounds. Methane is a gas at room temperature, methanol is a liquid. Same with ethane and ethanol, propane and propanol, and butane and butanol).

Just because something is an alcohol does not mean it will get you drunk.
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That's good to know thank you
 
The Holy Quadruplty said:
I take promethazine that gives me trippy effects to wear I can't even tell if I took a pill good or not, or even coughed some of it out or all of it, or then, like 10 minutes after taking them. Everytime I cough I feel like some could have even hours afterwards sometimes, even tho I don't ever see any coming out. I'm pretty sure it's just my mind fucking with me? Even if I take a pill sublingually and cough like 1 to 60 minutes after. What do you guys think about this?
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most def different, agian be safe young handsome lad~shakes finger atcha
Barely Famous No GIF by VH1
 
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deficiT said:
Merged all of your threads @The Holy Quadruplty

Drop your random queries here please from now on, I definitely already asked you once.

We're happy you're posting but each thought you have doesn't need its own thread, especially considering that they're basically all about similar things. Most of the threads on this subforums first page have been yours.
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Ok sorry.
 
darvocet21 said:
Be careful with those cigs they'll stunt your growth. At least we agree on one thing, although if you have access to good quality indica you can eliminate most of those synthetic sedatives
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If you're a downers person weed is more like a stimulant to me.

Just doesn't cut it.

Weed has been my bread and butter and most used drug out of 20 years of heavy poly drug use....but It's just because there's so little hangover withdrawal and consequences. It's just the easiest drug to use that causes the least problems.

Absolutely not a replacement for benzos or opioids tho. Shit sometimes I use weed and get too anxious and need a benzo.to bring me down a bit.

If you're a stimulant user I can see how weed would he considered kinda chill.

What I like about the weed the most is the afterglow after a full heavy day of smoking....mTHEN it feels like a downer (melatonin release is heavy at that stage).

But the peak of the high not so much.
 
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