• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

The Definitive Selegiline

A

AlphaMethylPhenyl

Moderator: TDS
Staff member
Joined
Jul 2, 2008
Messages
9,523
Location
Liminal
I have a couple questions about this compound. I realize this might not be too advanced...bear with me.

Why was it not approved for attention disorders?

Does it have nootropic qualities?

How do you think it compares to stimulants in terms of improving focus and motivation?

How much do l-methamphetamine and l-amphetamine, both metabolites, affect its overall affect?

Is it in any sense recreational?

I found some (dubious) answers to some of these questions online but I'd like to hear what the pros have to say. Some of them were old and others were posted by people without credentials.

Thanks!
 
Ho-Chi-Minh said:
I have a couple questions about this compound. I realize this might not be too advanced...bear with me.

Why was it not approved for attention disorders?

Does it have nootropic qualities?

How do you think it compares to stimulants in terms of improving focus and motivation?

How much do l-methamphetamine and l-amphetamine, both metabolites, affect its overall affect?

Is it in any sense recreational?

I found some (dubious) answers to some of these questions online but I'd like to hear what the pros have to say. Some of them were old and others were posted by people without credentials.

Thanks!
Click to expand...

Do you have a reference for the metabolism to l-meth and l-amph? If so I could look it over and let you know what I think.
 
Ho-Chi-Minh said:
http://www.ncbi.nlm.nih.gov/pubmed/8522918

http://www.ncbi.nlm.nih.gov/static/header_footer_ajax/submenu/#resources (these two are pretty old)

http://europepmc.org/abstract/MED/24350849

http://www.sciencedirect.com/science/article/pii/S2210533612000597

http://books.google.com/books?hl=en...egiline metabolism to methamphetamine&f=false
Click to expand...

Well according to that last link you posted 90% of selegiline is metabolized by first pass metabolism. Therapeutic formulations of selegiline range from 1-5mg. At the 1mg dose even if 90% was converted directly to l-meth it probably wouldn't be noticeable. If 90% of the 5mg dose is converted directly into l-meth there could be a noticeable effect.


I think it's more likely that much less of each dose is actually converted into l-meth. Unfortunately I didn't find any indication of what % gets converted into each metabolite, so without that this is all just guesswork.
 
There is a lot of published information about Selegiline. Just search on pubmed / google scholar and you'll find all the information you need. It's quite a researched and well known substance. Based on my personal experience, I can answer the following:

Does it have nootropic qualities? Yes. You are more alert and awake, as if you had slept very well. It allows you to reach your optimum level, though not above it.

How do you think it compares to stimulants in terms of improving focus and motivation? It really improves motivation, but I have not felt any special increase in focus. It really can't be compared to stimulant drugs, as with them I feel a sort of "push" while with Selegiline the "push" is just optional. You can take it or leave it depending on what you want.

How much do l-methamphetamine and l-amphetamine, both metabolites, affect its overall affect? It definitely feels somewhat stimulating or "alert-evoking", though I can't say if that is because of MAO-B inhibition, l-(meth)amp, or both of them. Probably it has more to do with MAO-B than with it's metabolites, which mainly act peripherally.

Is it in any sense recreational? Yes, and quite a lot. It is an enhancer of life without having to pay any kind of price for it.

I must also recommend a mandatory read through the Selegiline Wiki: http://wiki.bluelight.org/index.php/Selegiline
 
Recreational? Absolutely not. It may be useful and beneficial, but it's not in any way enjoyable. At least at MAO-B selective doses it isn't. I never took doses where it would lose selectivity.
 
Why was it not approved for attention disorders? Tis a mastery to me


Does it have nootropic qualities? SUre did for me. better at math and organizing/multitasking.

How do you think it compares to stimulants in terms of improving focus and motivation? For me, after several weeks of use, it's close enough to stims for me, for the aforementioned benefits,

How much do l-methamphetamine and l-amphetamine, both metabolites, affect its overall affect? I am very sensitive to amphetamine because of crohns and a sensitive body, and I defo don't enjoy the amphetamine effects,even if it's a homeoepathic amount! from that or the MAOi qualltities i get mucho insomnia for the induction phase.

Is it in any sense recreational? I love taking it for socialbilty, confidense, and horniness. I feel the the best version of myself when I'm continually using it.

I found some (dubious) answers to some of these questions online but I'd like to hear what the pros have to say. Some of them were old and others were posted by people without credentials.

Thanks!
 
You must log in or register to reply here.
Top